Polymeric Nanoencapsulation of Indocyanine green for Photodynamic Therapy Technique

Saboktakin, Mohammadreza

doi:10.34297/ajbsr.2019.03.000630

Cited by 2 publications

(1 citation statement)

References 161 publications

(156 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, ICG is limited in its use as a photosensitizer due to its fast degradation and poor stability in the body [ 14 ]. Therefore, various nanomaterials have been evaluated for their efficacy in overcoming the limitations of ICG [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Dual-functional alginate and collagen–based injectable hydrogel for the treatment of cancer and its metastasis

Hwang

Zhang

et al. 2022

J Nanobiotechnol

View full text Add to dashboard Cite

Background Immunotherapies have been gaining attention for the prevention of cancer recurrence and metastasis. Cancer immunotherapy can induce memory cells to target cancer-specific antigens and, thus, selectively kill cancer cells. However, there are difficulties in inducing cancer antigen–specific immunity due to limited knowledge regarding cancer antigens. In this study, we synthesized a dual-functional hydrogel to induce antigen generation and immune activation. Results To elicit a cancer self-antigen–specific immune response, we synthesized an alginate-collagen–based injectable hydrogel, called thermally responsive hydrogel (pTRG), which was incorporated with indocyanine green and the immune stimulator polyinosinic:polycytidylic acid (poly I:C). pTRG was evaluated for its anticancer and anti-metastatic effects against CT-26 carcinoma and 4T1 breast tumor in mice by combining photothermal therapy (PTT) and immunotherapy. Near-infrared (NIR) irradiation promoted temperature elevation in pTRG, consequently exerting a therapeutic effect on mouse tumors. Lung metastasis was prevented in cured CT-26 tumor-injected mice following pTRG treatment via cancer antigen–specific T cell immunity. Moreover, pTRG successfully eliminated the original tumor in 4T1 tumor-bearing mice via PTT and protected them from lung metastasis. To further evaluate the carrier function of TRGs, different types of immunotherapeutic molecules were incorporated into TRGs, which led to the effective elimination of the first CT-26 tumor and the prevention of lung metastasis. Conclusions Our data demonstrate that TRG is a efficient material not only for treating primary tumors but also for preventing metastasis and recurrence.

show abstract

Section: Introductionmentioning

confidence: 99%

Dual-functional alginate and collagen–based injectable hydrogel for the treatment of cancer and its metastasis

Hwang

Zhang

et al. 2022

J Nanobiotechnol

View full text Add to dashboard Cite

show abstract

The Dysregulated MAD in Mad: A Neuro-theranostic Approach Through the Induction of Autophagic Biomarkers LC3B-II and ATG

Panda

Singh

2023

Mol Neurobiol

View full text Add to dashboard Cite

Polymeric Nanoencapsulation of Indocyanine green for Photodynamic Therapy Technique

Abstract: This work is licensed under Creative Commons Attribution 4.0 License AJBSR.MS.ID.000630

Cited by 2 publications

References 161 publications

Dual-functional alginate and collagen–based injectable hydrogel for the treatment of cancer and its metastasis

Dual-functional alginate and collagen–based injectable hydrogel for the treatment of cancer and its metastasis

The Dysregulated MAD in Mad: A Neuro-theranostic Approach Through the Induction of Autophagic Biomarkers LC3B-II and ATG

Contact Info

Product

Resources

About