Imprinted Membranes for Sensor Technology:  Opposite Behavior of Covalently and Noncovalently Imprinted Membranes

Abstract

New types of polymeric membranes with molecular recognition sites for L-phenylalanine (L-Phe), 6-amino-1-propyluracil (APU), atrazine, and sialic acid have been prepared using the molecular imprinting approach. The membrane synthesis includes radical polymerization of ethylene glycol dimethacrylate (EDMA) and functional monomers in the presence of a template. Several compoundss-(diethylamino)ethyl methacrylate (DEAEM), methacrylic acid (MAA), allylamine (AA), and (4-vinylphenyl)boronic acidswere as functional monomers, which are able to form covalent, ionic, or hydrogen bonds with the corresponding templates. Template specific conductometric sensors, based on these polymers, were constructed and studied. An opposite response of covalently versus noncovalently imprinted membranes was demonstrated and discussed in detail. Sensors based on these materials could detect the target molecules at concentrations of 1-50 µM in solution. The high specificity and stability of these imprinted membranes render them promising alternatives to enzymes, antibodies, and other natural receptors usually used in sensor technology.

The rational development of molecularly imprinted polymer-based sensors for protein detection

“…16 The high specificity and stability of MIPs renders them promising alternatives to enzymes, antibodies, and natural receptors for use in sensor technology. 17,18 The growing interest in MIPs can be illustrated by the fact that almost 10% of all papers published on the subject of "biosensor" nowadays are MIP-related.…”

An Electrochemical Sensor for Phenylephrine Based on Molecular Imprinting

“…The sensing systems are based on an analyte bound to the MIPs membrane, itself, and reacts on the surface of a solid support on which MIPs are prepared, 3,4 or the characteristic alteration of MIPs membrane caused by binding the analyte. 5,6 Since the preparation of MIPs is simple and inexpensive, and as applicable to various molecules, MIPs have been ideal candidates as recognition elements for sensors.…”

Preparation of Molecularly Imprinted Composite Membranes for Inducing Bergenin Crystallization in Supercritical CO2and Adsorption Properties

“…11 In MIMs systems, the combination of the imprinting technique can provide membranes with specific selectivity for the separation of targeted organic compounds and thus make the MIMs possess the advantages of both molecular imprinting and membrane technology. [12][13][14] According to the preparation methods, MIMs can be generally divided into three categories, namedly molecularly imprinted filling membranes (MIFMs), molecularly imprinted monolithic membranes (MIMMs), and molecularly imprinted composite membranes (MICMs), 15 among which MICMs attract more attention because of their high flux of the resulted composite membranes and well flexibility of applications.…”