Imprinted and X-linked non-coding RNAs as potential regulators of human placental function

Buckberry, Sam; Bianco‐Miotto, Tina; Roberts, Claire T.

doi:10.4161/epi.26197

Cited by 42 publications

(32 citation statements)

References 127 publications

(132 reference statements)

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“…A complete qualitative and quantitative assessment of the miRNA landscape in the human placenta remains to be determined, although the subject has been recently reviewed (Fu et al 2013b;Buckberry et al 2014). Such an assessment will depend on the experimental conditions, the platforms used (e.g., microarray or RNAseq), and the use of a reliable cutoff for establishing expression.…”

Section: Expression and Function Of Trophomirs And Other Placental MImentioning

confidence: 99%

The Function of TrophomiRs and Other MicroRNAs in the Human Placenta

Sadovsky

Mouillet

Ouyang

et al. 2015

Cold Spring Harb Perspect Med

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In eutherian organisms, the placenta interfaces the fetal and maternal environments. Located at the placental villous surface, in direct contact with maternal blood, is the trophoblast layer, which mediates the crucial maternal-fetal exchange of gases, nutrients, and waste products, produces hormones that support the pregnancy, and provides immunologic defense. Discovery of microRNAs (miRNAs) and their role in development, differentiation, and homeostatic resilience has increased our understanding of genomic and epigenomic networks that regulate placental function. Moreover, unique miRNA species, which are expressed by human trophoblasts and are termed ‘trophomiRs’, may exhibit specialized functions during normal and pathological pregnancies. Placental miRNAs, packaged within exosomes and other vesicles or bound in protein complexes, are capable of communicating distinctive signals to maternal and/or fetal tissues. Additional research may usher in the use of circulating miRNAs as pregnancy-related disease biomarkers, providing new diagnostic and therapeutic options during pregnancy.

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Section: Expression and Function Of Trophomirs And Other Placental MImentioning

confidence: 99%

The Function of TrophomiRs and Other MicroRNAs in the Human Placenta

Sadovsky

Mouillet

Ouyang

et al. 2015

Cold Spring Harb Perspect Med

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“…Altered imprinting or epigenetic regulation of the H19 – Igf2 locus in human has been associated with altered placental and fetal growth as well as pregnancy complications ([18, 19], and reviewed in [20]). However, the underlying molecular mechanism of H19's role in placentation remains poorly defined.…”

Section: Introductionmentioning

confidence: 99%

H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction

Zuckerwise

et al. 2016

Oncotarget

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Fetal growth restriction (FGR) is a well-recognized risk factor for perinatal mortality and morbidity, as well as neurodevelopmental impairment and adulthood onset disorders. Here we report that the H19 long noncoding RNA (lncRNA) is significantly decreased in placentae from pregnancies with FGR. Downregulation of H19 leads to reduced migration and invasion of extravillous trophoblast (EVT) cells in vitro. This is consistent with reduced trophoblast invasion that has been observed in FGR. Genome-scale transcriptome profiling of EVT cells reveals significantly decreased expression of the type III TGF-β receptor (TβR3) following H19 knockdown. Decreased TβR3 expression is also seen in FGR placentae. TβR3 repression decreases EVT cell migration and invasion, owing to impaired TGF-β signaling through a non-canonical TGF-β signaling pathway. Further, we identify TβR3 as a novel regulatory target of microRNA let-7. We propose that dysregulation of this newly identified H19/TβR3-mediated regulatory pathway may contribute to the molecular mechanism of FGR. Our findings are the first to show a lncRNA-based mechanism of FGR, holding promise for the development of novel predictive, diagnostic, and therapeutic modalities for FGR.

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“…The imprinted C19 cluster of miRNAs is associated with pregnancy complications. Different miR members are important for placental primary trophoblast development (miR141, miR21) and for extravillous trophoblast invasion of the maternal decidua and myometrium (miR519) (131). Others are expressed in exosomes released from primary villous, which endow nontrophoblastic cells with resistance to viruses (132).…”

Section: Intergenerational Coadaptationmentioning

confidence: 99%