Epigenetic changes in the developing brain: Effects on behavior

Keverne, E.B.; Pfaff, Donald W.; Tabansky, Inna

doi:10.1073/pnas.1501482112

Cited by 56 publications

(30 citation statements)

References 149 publications

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“…For example, new discoveries resulted in the re-evaluation of the function of Golgi cells and Golgi’s theories of cellular connections (Kruger and Otis, 2007; Galliano et al, 2010). Likewise, modern discoveries in epigenetics have led to the up-dating of Darwin’s theory of evolution (Skinner, 2015) and our understanding of environmental influences on brain and behavior development and evolution (Keverne, 2014; Keverne et al, 2015). Likewise, the discovery of letters from Sigmund Freud to his school friend, Eduard Silberstein, not published until 1990 (Boehlich, 1990) give new insight into Freud as a student.…”

Section: History Is the Study Of What Remainsmentioning

confidence: 99%

Why Study the History of Neuroscience?

Brown

2019

Front. Behav. Neurosci.

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The history of neuroscience is the memory of the discipline and this memory depends on the study of the present traces of the past; the things left behind: artifacts, equipment, written documents, data books, photographs, memoirs, etc. History, in all of its definitions, is an integral part of neuroscience and I have used examples from the literature and my personal experience to illustrate the importance of the different aspects of history in neuroscience. Each time we talk about the brain, do an experiment, or write a research article, we are involved in history. Each published experiment becomes a historical document; it relies on past research (the “Introduction” section), procedures developed in the past (“Methods” section) and as soon as new data are published, they become history and become embedded into the history of the discipline (“Discussion” section). In order to be transparent and able to be replicated, each experiment requires its own historical archive. Studying history means researching books, documents and objects in libraries, archives, and museums. It means looking at data books, letters and memos, talking to scientists, and reading biographies and autobiographies. History can be made relevant by integrating historical documents into classes and by using historical websites. Finally, conducting historical research can be interesting, entertaining, and can lead to travel to out-of-the-way and exotic places and meeting interesting people.

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Section: History Is the Study Of What Remainsmentioning

confidence: 99%

Why Study the History of Neuroscience?

Brown

2019

Front. Behav. Neurosci.

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“…There is some evidence that shows that epigenetic modifications can influence the development of the brain [36]. Many studies support the concept of microRNAs as a biomarker of psychiatric diseases [37, 38].…”

Section: The Mechanisms Behind Social Isolation Rearing-induced Neuromentioning

confidence: 99%

“…However, in order to determine if social isolation rearing can produce a biomarker that can predict the occurrence of psychiatric diseases in adulthood, more studies should be done. However, because of a lack of proper in vitro models, the detailed mechanism for such modifications is not well understood [36]. Recent studies support the evidence that with the application of stem cell treatment new advances in the understanding of epigenetics about brain development can be achieved [39].…”

Section: The Mechanisms Behind Social Isolation Rearing-induced Neuromentioning

confidence: 99%

Social Isolation Rearing Induces Neuropsychiatric Diseases: Updated Overview

Famitafreshi

Karimian

2018

Complex Psychiatry

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Neuropsychiatric and neurologic diseases cause a great burden for individuals, families, and societies. Social isolation rearing can trigger a variety of psychiatric diseases. New advances suggest that epigenetic factors along with other neurochemical changes can be an important topic in neuropsychiatric diseases. It is thought that the prevention of social isolation rearing that occurs around birth can reduce the occurrence of neuropsychiatric diseases. It has been suggested that the environment can induce epigenetic alternation. So, for the diagnosis of a proportion of neuropsychiatric diseases, assessing epigenetic factors may be helpful. Also, apart from epigenetic factors, new advances have been made about new mechanisms of and treatments for such a disorder.

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“…In a recent study, entitled "Epigenetic changes in the developing brain: Effects on behavior" has been discussed how methylation works to stamp in painful memory and imprint it (Keverne, Pfaff & Tabansky, 2015). The researchers noted that there are adverse effects on the feeling/hippocampus areas.…”

Section: On the Breakdown Of Our Adaptive Capacitymentioning

confidence: 99%

Epigenetics and Primal Therapy

Janov

2015

Act Nerv Super

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Epigenetics is focused on the study of how experience changes an individual's genetic expression, previously considered inalterable. Recent pioneering research indicates that epigenetics is revolutionizing the study of mental health and challenging the belief that DNA is destiny. Moreover, in terms of the history of science, the new developments augur the convergence of previously distinct fields, psychology and biology. There is a growing understanding that mental illness has a crucial physical component and may cause disturbances of mind and body which strongly emphasis a crucial role of psychotherapy focused on early stressful experiences mainly during critical developmental periods including prenatal and perinatal traumas.

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Epigenetic changes in the developing brain: Effects on behavior

Cited by 56 publications

References 149 publications

Why Study the History of Neuroscience?

Why Study the History of Neuroscience?

Social Isolation Rearing Induces Neuropsychiatric Diseases: Updated Overview

Epigenetics and Primal Therapy

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