Impotence in Elderly Men

Morley, John E.; Kaiser, Fran E.

doi:10.2165/00002512-199202040-00006

Cited by 19 publications

(10 citation statements)

References 107 publications

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“…The common occurrence of malnutrition/weight loss as a diagnosis is in accord with the literature suggesting that this is a major geriatric problem 19,20 . Sexual dysfunction 21 and osteoporosis 22 are common geriatric problems. Psychiatric problems represent an important facet of geriatric medicine as demonstrated by these diagnoses.…”

Section: Geriatrics In Practice: Primary Care Discipline Of Subspeciasupporting

confidence: 75%

Geriatric Medicine: A True Subspecialty

Morley¹

1993

J American Geriatrics Society

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Section: Geriatrics In Practice: Primary Care Discipline Of Subspeciasupporting

confidence: 75%

Geriatric Medicine: A True Subspecialty

Morley¹

1993

J American Geriatrics Society

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“…Why was the incidence of ED actually greater in treated hypertensive patients versus those that were untreated? It is known that some of the antihypertensive medications themselves may worsen ED [7,29]. The results of comparative trials suggest that the thiazide diuretics (such as chlorthalidone) are the most likely to induce ED, followed by the β blockers [30][31][32][33][34].…”

Section: Hypertensionmentioning

confidence: 99%

Erectile dysfunction and atherosclerosis

Kloner

Speakman

2002

Curr Atheroscler Rep

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Erectile dysfunction (ED) is a common problem in the United States, with estimates that 30 million men suffer with some degree of ED. Although causes include psychogenic, organic, and mixed forms, in middle-aged and older men one of the most common causes is vascular disease. Endothelial dysfunction, even without definitive arterial stenosis, as well as atherosclerosis with definitive stenosis of blood vessels, contributes to the problem. Endothelial dysfunction and atherosclerosis of blood vessels that supply the penis are associated with the same cardiovascular risk factors that affect the coronary arteries: smoking, lipid abnormalities, hypertension, and diabetes.

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“…In men over middle age, ED is generally vascular-derived and it forms 40-50% of all etiologic factors. 15,16 Our opinion is that reasons at the molecular level related to these high-rate etiologic factors should be researched and identified. It is known that atherosclerotic lesions prevent blood flow into cavernosal tissues and cause ED.…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase activity in patients with erectile dysfunction

et al. 2007

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Paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme that protects lowdensity lipoprotein (LDL) and HDL from peroxidation. In this study, PON1 activities were determined in patients with erectile dysfunction (ED) to investigate the relationship between ED and atherosclerosis. Forty patients, who had been diagnosed with ED by the medical and sexual anamnesis and routine laboratory tests, were included in the study. Thirty healthy, sexually active, married and age-matched men were selected as the control group. The patients and controls who underwent surgical or medical treatment in 1-week time and had a systemic disease such as malignancy, liver and renal insufficiency, and active infection and who smoked cigarettes were excluded. PON1 activities were measured spectrophotometrically. Unpaired samples t-test, correlation analyses and multiple linear regression analyses were used for statistical analyses. The results are given as mean7standard deviation of mean. The mean ages of the patient and the control groups were 31.0576.90 (range 22-51) and 29.4076.26 (range 19-46), respectively (P ¼ 0.307). Serum PON1 levels of the patient and the control groups were found to be 119.05762.11 and 185.04755.64, respectively. The difference between the groups was quite significant (P ¼ 0.001). Epidemiological and experimental studies indicate that PON1 activation was lower in individuals who had a tendency to develop atherosclerosis due to comorbidities such as diabetes, familial hypercholesterolemia and kidney disease. In this study, PON1 activity level was found to be significantly lower in ED patients than in control group. The decrease of PON1 activity may have a role in the ethiopathogenesis of ED, and the atherosclerosis development may be faster in the patients due to decreased activity of PON1, which is an antiatherogenic enzyme.

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Impotence in Elderly Men

Cited by 19 publications

References 107 publications

Geriatric Medicine: A True Subspecialty

Geriatric Medicine: A True Subspecialty

Erectile dysfunction and atherosclerosis

Paraoxonase activity in patients with erectile dysfunction

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