Important Regulatory Role of Activated Platelet-Derived Procoagulant Activity in the Propagation of Thrombi Formed Under Arterial Blood Flow Conditions

Platelets: Small in Size But Essential in the Regulation of Vascular Homeostasis – Translation From Basic Science to Clinical Medicine –

“…43 Local generation of thrombin on platelet thrombi formed on collagen fibrils was also demonstrated previously to support the close link between platelet and coagulation. 57 There are several thrombin receptors on the surface of platelets. 58 These thrombin receptors are efficiently activated by locally generated thrombin and further activate the platelet.…”

Tissue Factor and Cardiovascular Disease: Quo Vadis?

“…Interestingly, stimulated platelets in a growing thrombus may additionally induce activation of coagulation factors; thus, there is evidence that the coagulation systems may play a role in both thrombus initiation and propagation. 4 In clinical practice, the activity of the extrinsic pathway is measured by the prothrombin time, while the activated partial prothrombin time quantifies the function of the intrinsic system.…”

Safety and Exploratory Efficacy of the Novel Thrombin Receptor (PAR-1) Antagonist SCH530348 for Non-ST-Segment Elevation Acute Coronary Syndrome

“…Importantly, thrombin-mediated cleavage of fibrinogen into fibrin may be more critical for hemostasis than platelet activation induced by thrombin through PAR-1 13) . Thrombin plays a key role in the positive feedback between activation of the platelet and coagulation cascades 14) . Preclinical studies have shown that PAR-1 antagonism inhibits thrombin-stimulated platelet aggregation and pathogenic thrombus growth without prolonging bleeding time 15) , supporting the concept that the PAR-1 pathway may not have a significant role in hemostasis.…”