Importância do hormônio anti-Mülleriano na infertilidade

Kurobe, Flavia Machado Cella; Dzik, Artur; Cavagna, M.; Drezett, Jefferson

doi:10.1016/j.recli.2013.03.003

Cited by 2 publications

(2 citation statements)

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“…These women tend to form several antral follicles whose development is interrupted prematurely (De Leo et al 2016). The combination of these factors induces most follicles to stop at a small antral stage (Azziz et al 2016), acquiring up to 2-5 mm in diameter, which is two to three times larger than that observed in normal ovaries (Kurobe et al 2012).…”

Section: Pathophysiology Of Pcosmentioning

confidence: 76%

“…This hormone is produced by granulosa cells and, in normal women, acts on the primordial follicle, inhibiting the recruitment of many follicles, and attenuates the effects of FSH on growing follicles. In women with PCOS, high levels of AMH lead to follicular resistance to FSH, which also impairs the follicle growth (Kurobe et al 2012), selection of a dominant follicle, and recruitment of more primordial follicles (Azziz et al 2016). Furthermore, considering that FSH is also important to stimulate granulosa cells to convert androgens to estrogens (Chang et al 2013), the antagonism of AMH to FSH contributes to hyperandrogenism in PCOS (Azziz et al 2016).…”

Section: Pathophysiology Of Pcosmentioning

confidence: 99%

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Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

Carvalho

Reis

Cândido

et al. 2018

Endocrine Regulations

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Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism, amenorrhea, and polycystic ovaries. This endocrinopathy is associated with many metabolic disorders such as dyslipidemia and insulin resistance, with increased risk of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular complications. Inflammation is likely to play an important role in the promoting these metabolic imbalances, while prothrombotic and pro-oxidative mechanisms further contribute to the cardiovascular risk of these patients. The etiology of PCOS is still not fully understood, but there is evidence of genetic and environmental components. This review aims to discuss some molecular pathways associated with PCOS that could contribute to the better understanding about this syndrome. Recent evidence suggests that intrauterine exposure of female mice to an excess of anti-Müllerian hormone may induce PCOS features in their post-natal life. High cytokine levels and cytokine gene polymorphisms also appear to be associated with the pathophysiology of PCOS. Furthermore, high levels of microparticles may contribute to the altered hemostasis and enhanced inflammation in PCOS. All these mechanisms may be relevant to clarify some aspects of PCOS pathogenesis and inspire new strategies to prevent the syndrome as well as treat its symptoms and mitigate the risk of long-term complications.

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Section: Pathophysiology Of Pcosmentioning

confidence: 76%