Importance of vitamin-A for lung function and development

Biesalski, Hans Konrad; Nöhr, Donatus

doi:10.1016/s0098-2997(03)00039-6

Cited by 101 publications

(86 citation statements)

References 37 publications

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“…Interestingly, our study showed that rats in the control group accumulated retinol in the lungs for the 22 d of this study despite the VA-marginal conditions. This trend may reflect the need for retinol in the lungs to support the process of secondary alveolar septation, which in rats occurs from postnatal days 1 to 14, unlike in humans, in whom this process is completed during gestation (24).…”

Section: Discussionmentioning

confidence: 99%

Vitamin A Supplementation Transiently Increases Retinol Concentrations in Extrahepatic Organs of Neonatal Rats Raised under Vitamin A–Marginal Conditions

Hodges

Tan

Green

et al. 2016

The Journal of Nutrition

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Section: Discussionmentioning

confidence: 99%

Vitamin A Supplementation Transiently Increases Retinol Concentrations in Extrahepatic Organs of Neonatal Rats Raised under Vitamin A–Marginal Conditions

Hodges

Tan

Green

et al. 2016

The Journal of Nutrition

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“…Nevertheless, there are immune system and tissue repair disorders, which affect mainly the respiratory epithelium. 1,27 The study shows that the mean serum retinol level in the period of resolution of pneumonia was significantly higher in the acute phase of infection. We also observed low serum retinol levels in 32.5 and 17.5% of the children during the acute phase and after resolution of pneumonia, respectively.…”

Section: Discussionmentioning

confidence: 92%

“…VAD may lead to squamous metaplasia with subsequent loss of defense mechanisms against microbial invasion and to the development of obstructive phenomena caused by bronchial hyperresponsiveness. 1 It is commonly known that micronutrient deficiency is associated with the etiology and aggravation of infectious diseases, and that infection is one of the causes of nutrient depletion. Epidemiologically, the most widely investigated deficiencies are those of vitamin A and iron.…”

Section: Introductionmentioning

confidence: 99%

Níveis plasmáticos de vitamina A em crianças carentes com pneumonia na fase aguda e após recuperação

Silva¹,

Lopes²,

Sarni³

et al. 2005

J. Pediatr. (Rio J.)

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Suggested citation: da Silva R, Lopes Jr E, Sarni RO, Taddei JA. Plasma vitamin A levels in deprived children with pneumonia during the acute phase and after recovery. J Pediatr (Rio J). 2005;81:162-8. AbstractObjective: The aim of this study was to examine the plasma retinol of children in the acute phase of pneumonia and after recovery and to investigate the association between plasma levels of retinol after recovery with socioeconomic variables, nutritional status and severity of pneumonia.Methods: A prospective cohort study which included 40 low-income hospitalized children with pneumonia, aged 6 months to 5 years. We evaluated: plasma retinol level during the acute phase and after recovery, years of schooling of the head of the family, per capita income, birth weight, nutritional status, hemoglobin levels and severity of pneumonia.Results: Mean plasma retinol levels were significantly higher after recovery than during the acute phase of infection (1.4±0.6 vs. 1.7±0.6 µmol/l, p = 0.03). The frequency of inadequate plasma retinol levels (< 1.05 µmol/l) was 32.5 and 17.5% for the acute phase and after recovery, respectively. There were no statistically significant associations between plasma retinol deficiency and the clinical and epidemiological variables studied. More severe pneumonia was observed in 30/40 (75%) of the patients. There was no statistically significant association between plasma retinol inadequacy after recovery and severity of pneumonia (4/30 13.3% vs. 3/10 30.0%, p = 0.34).Conclusion: Serum retinol levels were significantly higher after recovery than during the acute phase of pneumonia. There was no statistically significant association between the deficiency of serum retinol and the clinical and epidemiological variables studied.J Pediatr (Rio J). 2005;81(2):162-8: Vitamin A, nutritional status, children, pneumonia.

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“…During the saccular period, RA stimulates proliferation of the stem cells of the alveolar epithelium through an EGFmediated pathway (Schuger et al, 1993;Massaro and Massaro, 1996). During the alveolar period, retinoids are effective in promoting alveolar subdivision or septation (Hind et al, 2002;Biesalski and Nohr, 2003).The absence of RXRg and RARg expression was already established during lung development in mice (Dolle et al, 1990 and and rats (Grummer et al, 1994) even if some studies supported the presence of some isoforms of RARg? (Grummer et al, 1994;McGowan et al, 1995;Hind et al, 2002;Biesalski and Nohr, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…During the alveolar period, retinoids are effective in promoting alveolar subdivision or septation (Hind et al, 2002;Biesalski and Nohr, 2003).The absence of RXRg and RARg expression was already established during lung development in mice (Dolle et al, 1990 and and rats (Grummer et al, 1994) even if some studies supported the presence of some isoforms of RARg? (Grummer et al, 1994;McGowan et al, 1995;Hind et al, 2002;Biesalski and Nohr, 2003). Three RARs and three RXRs have been demonstrated in the developing human lung (Rajatapiti et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Expression of retinoid receptors during rabbit lung development

Coste

Gallot²,

Marceau³

et al. 2007

Animal

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Rabbit lung is often used to study the pathophysiology of some congenital anomalies affecting the lung because its development is very comparable with that of human. Retinoids and the molecular transducers of the retinoic signal play a crucial role in mammalian lung development. In the rabbit, the molecular retinoic pathway has so far been poorly studied. As a first step in elucidating this process, we aimed to identify the retinoic acid receptors (RARs) and retinoid X receptors (RXRs). We cloned a part of the nuclear receptors (RARs and RXRs), and we used reverse transcription -polymerase chain reaction (RT-PCR) and immunohistochemistry assays to demonstrate the presence of RAR (a,b) and RXR (a, b) at all stages of rabbit lung development. Our results initiate further analysis into the molecular and genetic functions of retinoids during normal and pathological rabbit lung development including the surgical model of congenital diaphragmatic hernia.Keywords: lung development, rabbits, retinoids, retinoic acid receptor, retinoid X receptor IntroductionMany factors including hormonal, biochemical and physical factors have been identified that modulate growth and development of the lung (Keijzer et al., 2000;Cardoso, 2001;Copland and Post, 2004;Rajatapiti et al., 2005). Among the variety of biochemical agents identified so far, retinoids (active derivatives of vitamin A) play a clearly defined role in lung development at its different stages (Gallot et al., 2005;Maden, 2004). Vitamin A (retinol) exerts important effects upon a vast number of development processes via signalling through heterodimerization complexes comprising retinoic acid receptors (RARs) and retinoid X receptors (RXRs) (Chambon, 1996). These receptors belong to the steroid/thyroid hormone receptor super family of ligand-inducible transcription regulators known to control the expression of target genes. All members of this family share a strongly conserved modular structure with discrete functional domains for ligand binding, DNA binding and transactivation. There are three RAR isotypes (RARa, b, g) activated by both all-trans and 9-cis retinoic acid (RA) and three retinoid X receptors (RXRa, b, g) only activated by 9-cis RA (Bastien and Rochette-Egly, 2004).The RAR and RXR proteins interact with each other to form RAR/RXR heterodimers which are able to bind to specific DNA sequences called RA responsive elements usually located within the 5 0 -regulatory region of retinoid-regulated genes.The importance of vitamin A in vertebrate lung development was first demonstrated by the observation that foetuses from pregnant rats which were fed a vitamin Adeficient diet had either agenesis of the left lung or rudimentary lung buds (Warkany and Wilson, 1948;Chazaud et al., 2003). Double mutant mice RARa, b 2/2 revealed defects comparable with the consequences of vitamin A deficiency including hypoplastic lungs (Mendelsohn et al., 1994;Kastner et al., 1997;Mascrez et al., 1998). Abnormalities in the vitamin A status and/or metabolism may also play a role in t...

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Importance of vitamin-A for lung function and development

Cited by 101 publications

References 37 publications

Vitamin A Supplementation Transiently Increases Retinol Concentrations in Extrahepatic Organs of Neonatal Rats Raised under Vitamin A–Marginal Conditions

Vitamin A Supplementation Transiently Increases Retinol Concentrations in Extrahepatic Organs of Neonatal Rats Raised under Vitamin A–Marginal Conditions

Níveis plasmáticos de vitamina A em crianças carentes com pneumonia na fase aguda e após recuperação

Expression of retinoid receptors during rabbit lung development

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