Importance of vascular endothelial growth factor (VEGF) in ovarian physiology of mammals

Araújo, Valdevane Rocha; Duarte, A.B.G.; Bruno, Jamily Bezerra; Lopes, C.A.P.; Figueiredo, J.R.

doi:10.1017/s0967199411000578

Cited by 43 publications

(35 citation statements)

References 87 publications

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“…In summary, VEGF-A is a strong mitogenic factor that stimulates the proliferation and migration of vascular endothelial cells for the creation and maintenance of vascular structures [8]. In contrast, ANGPTs are not mitogenic, but they are fundamental to the construction of vessels [9].…”

Section: Angiogenesis and Main Angiogenic Factorsmentioning

confidence: 99%

“…There is also increasing evidence that VEGF has extravascular effects in the ovary [8,23,24]. It is worthy to investigate other than vascular (extravascular) actions of VEGF in the growing follicle, to provide information about VEGF as a possible marker for high-quality follicles destined to provide a mature oocyte capable of fertilization.…”

Section: Angiogenesis and Ovarian Functionmentioning

confidence: 99%

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Molecular regulation and role of angiogenesis in reproduction

Rizov¹,

Andreeva

Dimova

2017

Taiwanese Journal of Obstetrics and Gynecology

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Angiogenesis is an essential process for proper functioning of the female reproductive system and for successful pregnancy realization. The multitude of factors required for physiological angiogenesis and the complexity of regulation of their temporal-spatial activities contribute to aberrations in human fertilization and pregnancy outcomes. In this study, we reviewed the current knowledge of the temporal expression patterns, functions, and regulatory mechanisms of angiogenic factors during foliculogenesis, early implantation/placentation and embryo development, as well as recurrent spontaneous abortions. Angiogenic factors including vascular endothelial growth factors and angiopoietins have documented roles in the development of primordial follicles into mature antral follicles. They also participate in decidualization, which is accompanied by the creation of an extensive network of vessels in the stromal bed that support the growth of the embryo and the placenta, and maintain early pregnancy. During placentation angiogenic and angiomodulatory cytokines, T and B lymphocytes and macrophages affect angiogenesis in a context-dependent manner. Defects in angiogenesis at the maternal-fetal interface contribute to miscarriage in humans. The establishment of more polymorphisms in the genes involved in angiogenesis/vasculogenesis, and their pathological phenotype and expression could give opportunities for prediction, creating a therapeutic strategy, and treatment of diseases related to female reproductive health and problematic conception.

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Section: Angiogenesis and Main Angiogenic Factorsmentioning

confidence: 99%

Section: Angiogenesis and Ovarian Functionmentioning

confidence: 99%

Molecular regulation and role of angiogenesis in reproduction

Rizov¹,

Andreeva

Dimova

2017

Taiwanese Journal of Obstetrics and Gynecology

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“…VEGF has been known as a regulator of the various phases of follicle development [116]. Yang and Fortune [34] demonstrated that the mRNA for both VEGF receptors (flt-1 or VEGFR-1 and flk-1 or VEGFR-2), as well as for the VEGF ligand, were expressed in the fetal bovine ovary at day 90 of gestation.…”

Section: Reviewmentioning

confidence: 99%

In vitro culture of bovine preantral follicles: a review

Araújo

Gastal

Figueiredo

2014

Reprod Biol Endocrinol

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Preantral follicles are the majority of the ovarian follicle population and their use as a source of homogeneous oocytes for bovine reproductive biotechnologies could result in a substantial advance in this field. However, while in other species embryos and offspring have been produced, in bovine species the results have been limited to the follicular activation of small (primordial) preantral follicles and formation of early antral follicles from large (secondary) preantral follicles after in vitro culture. Therefore, this review will highlight the basic aspects of bovine folliculogenesis by focusing on preantral follicles, the methods of harvesting preantral follicles, the main results from in vitro follicular culture during the last 20 years, and the potential candidate substances (basic supplements, growth factors, and hormones) for improving the efficiency of in vitro follicle growth.

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“…By disrupting the genes that encode either of these proteins in mammals, both the follicle cells and oocytes are prevented from normal development, causing female sterility. Follicle cells secrete macromolecules that either contribute to the oocyte coat, are taken up by receptor-mediated endocytosis into the growing oocyte, or act on oocyte surface receptors to control the spatial patterning and axial asymmetries of the oocyte (17)(18)(19).…”

Section: Follicular Growthmentioning

confidence: 99%

Ovarian function following targeted anti-angiogenic therapy with bevacizumab

Imai

Ichigo

Matsunami

et al. 2017

Molecular and Clinical Oncology

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Abstract. Improvements in cancer therapy have enabled further insight into the long-term effects of treatment, including the highly prevalent gonadal failure. The focus of treatment has been shifted to the preservation of fertility, which may be achieved by preventing ovarian toxicity. To this end, new molecular-targeted agents, including monoclonal antibodies, have been developed and used in a standard procedure for managing different cancers. However, the prolonged antitumor activity of these drugs may cause the emergence of new toxic effects. The aim of the present review was to discuss the leading toxic effect of the anti-angiogenic agent bevacizumab on ovarian function in female patients of reproductive age, which may be observed and expected during in clinical practice. The majority of bevacizumab-induced side effects are expected to be transient and eliminated within the anticipated drug clearance time frame; however, fundamental investigations on these effects are required for generating more evidence-based practice guidelines.

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Importance of vascular endothelial growth factor (VEGF) in ovarian physiology of mammals

Cited by 43 publications

References 87 publications

Molecular regulation and role of angiogenesis in reproduction

Molecular regulation and role of angiogenesis in reproduction

In vitro culture of bovine preantral follicles: a review

Ovarian function following targeted anti-angiogenic therapy with bevacizumab

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