Importance of the iron–sulfur component and of the siroheme modification in the resting state of sulfite reductase

Brânzanic, Adrian M.V.; Ryde, Ulf; Silaghi‐Dumitrescu, Radu

doi:10.1016/j.jinorgbio.2019.110928

Cited by 6 publications

(17 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[29][30][31][32][33][34][35][36][37][38][39][40][41][42] We have, more in general, shown that even within the same class of compounds the performance of a functional can vary widely depending on the property sought, or on apparently simple changes in ligands (e.g., axial ligation in heme complexes). [43][44][45][46] The methodology employed here was selected for its ability to best mimic trends in UV-vis spectra as described in our previous study on hydroperoxocobalamin, thus also allowing consistency between the two sets of data. In terms of general structural features, the cobalamin-peroxo adducts (unlike, e.g., the case of Cbl(I)) offer no particular challenge -so that the choice of functional should affect the results at the level of detail (which, nevertheless, in predicting trends in UV-vis maxima of Cbl adducts, is essential).…”

Section: Methodsmentioning

confidence: 99%

“…, axial ligation in heme complexes). 43–46 The methodology employed here was selected for its ability to best mimic trends in UV-vis spectra as described in our previous study on hydroperoxocobalamin, thus also allowing consistency between the two sets of data. In terms of general structural features, the cobalamin-peroxo adducts (unlike, e.g.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A complex of cobalamin with an organic peroxide

Lehene,

Zăgrean-Tuza,

Hădade

et al. 2023

New J. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

A complex of cobalamin with an organic peroxide

Lehene,

Zăgrean-Tuza,

Hădade

et al. 2023

New J. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“…For SPLET, the phenolic compound first abandons a proton to form a phenoxy anion. Subsequently, an electron in PhO − transfers to the active radical, forming an anion that combined with H + to form RH to scavenge the free radical [37,38]. These mechanisms may occur in the antioxidant process, but different compounds have their own trends and reaction rates.…”

Section: Theoretical Mechanismmentioning

confidence: 99%

Elution–extrusion counter‐current chromatographic separation and theoretical mechanism of antioxidant from Robinia pseudoacacia flower

Liu

Zhang

Tang

et al. 2023

J of Separation Science

View full text Add to dashboard Cite

Robinia pseudoacacia flowers have attracted much attention because of numerous bioactivities. In this study, its extract showed the potential scavenging ability for 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonate) and 1,1-diphenyl-2-picrylhydrazyl free radicals. Under the guidance of antioxidant activity, the antioxidant extract was enriched by liquid-liquid extraction. The partition coefficients of the two main components in antioxidant extracts differed greatly, so in this study, elution-extrusion counter-current chromatography with the solvent system of n-hexane-ethyl acetate-methanol-water (2.5:5:2.5:5, v/v) was used to enhance the separation efficiency, and the two main components were successfully obtained. Among them, kaempferol showed strong antioxidant activity, which can be responsible for the activity of the extract. In order to deeply understand the antioxidant mechanism of kaempferol, the thermodynamics, frontier molecular orbital, and kinetics of scavenging free radicals were investigated by density functional theory. The results showed that 4′-OH in kaempferol was the most active group, which can scavenge free radicals by hydrogen atom transfer in non-polar solvents and activate 3-OH to generate double hydrogen atom transfer in the gas phase. But in polar solvents, it was more inclined to clear radicals through single electron transfer and proton transfer. The kinetic result showed that kaempferol needed 9.17 kcal/mol of activation energy to scavenge free radicals.

show abstract

“… 2005 ). Sulfite reductase has two types of structures; α, β and γ heteromeric structure and α2β2 heterotetrameric structure (Brânzanic, Ryde and Silaghi-Dumitrescu 2020 ). The sulfite reductase complex of S. pombe is expected to be the α2β2 type.…”

Section: Sulfur Metabolism In S Pombementioning

confidence: 99%

Response to sulfur in Schizosaccharomyces pombe

Ohtsuka

Shimasaki

Aiba

2021

FEMS Yeast Research

View full text Add to dashboard Cite

Sulfur is an essential component of various biologically important molecules, including methionine, cysteine, and glutathione, and it is also involved in coping with oxidative and heavy metal stress. Studies using model organisms, including budding yeast (Saccharomyces cerevisiae) and fission yeast (Schizosaccharomyces pombe), have contributed not only to understanding various cellular processes but also to understanding the utilization and response mechanisms of each nutrient, including sulfur. Although fission yeast can use sulfate as a sulfur source, its sulfur metabolism pathway is slightly different from that of budding yeast because it does not have a trans-sulfuration pathway. In recent years, it has been found that sulfur starvation causes various cellular responses in S. pombe, including sporulation, cell cycle arrest at G2, chronological lifespan extension, autophagy induction, and reduced translation. This MiniReview identifies two sulfate transporters in S. pombe, Sul1 (encoded by SPBC3H7.02) and Sul2 (encoded by SPAC869.05c), and summarizes the metabolic pathways of sulfur assimilation and cellular response to sulfur starvation. Understanding these responses, including metabolism and adaptation, will contribute to a better understanding of the various stress and nutrient starvation responses and chronological lifespan regulation caused by sulfur starvation.

show abstract

Importance of the iron–sulfur component and of the siroheme modification in the resting state of sulfite reductase

Cited by 6 publications

References 77 publications

A complex of cobalamin with an organic peroxide

A complex of cobalamin with an organic peroxide

Elution–extrusion counter‐current chromatographic separation and theoretical mechanism of antioxidant from Robinia pseudoacacia flower

Response to sulfur in Schizosaccharomyces pombe

Contact Info

Product

Resources

About