Response to sulfur in <i>Schizosaccharomyces pombe</i>

Ohtsuka, Hokuto; Shimasaki, Takafumi; Aiba, Hirofumi

doi:10.1093/femsyr/foab041

Cited by 9 publications

(7 citation statements)

References 87 publications

(136 reference statements)

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“…Further, ecl family genes are required to induce sporulation during sulfur starvation and induce sexual differentiation during iron or zinc starvation (Ohtsuka & Aiba, 2017 ; Ohtsuka et al, 2017 ). Although sulfur starvation induces autophagy and sporulation, and extends CLS, similarly to nitrogen starvation, it leads to neither G 1 arrest nor mating (Corral‐Ramos et al, 2021 ; Ohtsuka et al, 2017 , 2021d ; Shimasaki et al, 2020 ). Recently, it was reported that ecl family genes inhibit TORC1 activity (Ohtsuka et al, 2022a ).…”

Section: Molecular Basis Of Sporulation By S Pombementioning

confidence: 99%

Sporulation: A response to starvation in the fission yeast Schizosaccharomyces pombe

et al. 2022

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The fission yeast Schizosaccharomyces pombe employs two main strategies to adapt to the environment and survive when starved for nutrients. The strategies employ sporulation via sexual differentiation and extension of the chronological lifespan.When a cell is exposed to nutrient starvation in the presence of a cell of the opposite sex, the cells undergo fusion through conjugation and sporulation through meiosis.S. pombe spores are highly resistant to diverse stresses and may survive for a very long time. In this minireview, among the various sexual differentiation processes induced by starvation, we focused on and summarized the findings of the molecular mechanisms of spore formation in fission yeast. Furthermore, comparative measurements of the chronological lifespan of stationary phase cells and G 0 cells and the survival period of spore cells revealed that the spore cells survived for a long period, indicating the presence of an effective mechanism for survival. Currently, many molecules involved in sporulation and their functions are being discovered; however, our understanding of these is not complete. Further understanding of spores may not only deepen our comprehension of sexual differentiation but may also provide hints for sustaining life.

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Section: Molecular Basis Of Sporulation By S Pombementioning

confidence: 99%

Sporulation: A response to starvation in the fission yeast Schizosaccharomyces pombe

et al. 2022

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“…[203] In addition to the TORC1 pathway, several signaling pathways, including the PKA, Pmk1, and Sty1 pathways, regulate CLS in S. pombe. [204][205][206][207] Pmk1 is a MAPK that is a core effector of the cell integrity pathway and an extracellular signal-regulated kinase ERK ortholog. [208,209] The Pmk1 pathway is expected to have a negative effect on CLS extension because deletion of MAPK, MAPKK, and MAPKK kinase (MAPKKK) leads to extended CLS.…”

Section: Ethylenediaminetetraacetic Acidmentioning

confidence: 99%

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

Ohtsuka,

Shimasaki,

Aiba

2024

Advanced Biology

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Yeast is an excellent model organism for research for regulating aging and lifespan, and the studies have made many contributions to date, including identifying various factors and signaling pathways related to aging and lifespan. More than 20 years have passed since molecular biological perspectives are adopted in this research field, and intracellular factors and signal pathways that control aging and lifespan have evolutionarily conserved from yeast to mammals. Furthermore, these findings have been applied to control the aging and lifespan of various model organisms by adjustment of the nutritional environment, genetic manipulation, and drug treatment using low‐molecular weight compounds. Among these, drug treatment is easier than the other methods, and research into drugs that regulate aging and lifespan is consequently expected to become more active. Chronological lifespan, a definition of yeast lifespan, refers to the survival period of a cell population under nondividing conditions. Herein, low‐molecular weight compounds are summarized that extend the chronological lifespan of Saccharomyces cerevisiae and Schizosaccharomyces pombe, along with their intracellular functions. The low‐molecular weight compounds are also discussed that extend the lifespan of other model organisms. Compounds that have so far only been studied in yeast may soon extend lifespan in other organisms.

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“…Yeast can use sulfate as a source of sulfur, a necessary nutrient for growth, and an essential component of various biologically important molecules such as methionine, cysteine, and glutathione (Huang et al, 2017; Ohtsuka et al, 2021c). In S. pombe , sulfur starvation promotes nuclear accumulation of the transcription factor Zip1, which directly induces ecl1 + transcription (Ohtsuka et al, 2017).…”

Section: Signal Network Involved In Ecl Family Protein Inductionmentioning

confidence: 99%

“…Sulfur starvation induces ecl1 + expression by Zip1, leading to autophagy, sporulation, cell cycle arrest at G 2 , and CLS extension, whereas this starvation does not lead to G 1 arrest or mating (Corral‐Ramos et al, 2022; Ohtsuka et al, 2017, 2021c; Shimasaki et al, 2020).…”

Section: Signal Network Involved In Ecl Family Protein Inductionmentioning

confidence: 99%

ecl family genes: Factors linking starvation and lifespan extension in Schizosaccharomyces pombe

Ohtsuka

Otsubo

Shimasaki

et al. 2023

Molecular Microbiology

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In the fission yeast Schizosaccharomyces pombe, the duration of survival in the stationary phase, termed the chronological lifespan (CLS), is affected by various environmental factors and the corresponding gene activities. The ecl family genes were identified in the genomic region encoding non‐coding RNA as positive regulators of CLS in S. pombe, and subsequently shown to encode relatively short proteins. Several studies revealed that ecl family genes respond to various nutritional starvation conditions via different mechanisms, and they are additionally involved in stress resistance, autophagy, sexual differentiation, and cell cycle control. Recent studies reported that Ecl family proteins strongly suppress target of rapamycin complex 1, which is a conserved eukaryotic nutrient‐sensing kinase complex that also regulates longevity in a variety of organisms. In this review, we introduce the regulatory mechanisms of Ecl family proteins and discuss their emerging findings.

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Response to sulfur in Schizosaccharomyces pombe

Cited by 9 publications

References 87 publications

Sporulation: A response to starvation in the fission yeast Schizosaccharomyces pombe

Sporulation: A response to starvation in the fission yeast Schizosaccharomyces pombe

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

ecl family genes: Factors linking starvation and lifespan extension in Schizosaccharomyces pombe

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