Importance of SUVmax threshold in positron emission tomography-computed tomography assessment of mediastinal and hilar lymph nodes in non-small cell lung cancer

Yıldız, Oya; Cangır, Ayten; Kılıç, Dalokay; Yüksel, Cabir; Enön, Serkan; Kutlay, Hakan; Akal, Murat; Özdemır, Nezıh; Kavukçu, Şevket; Ökten, İlker

doi:10.5606/tgkdc.dergisi.2016.10982

Cited by 2 publications

(2 citation statements)

References 13 publications

(17 reference statements)

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“…Because CT evaluates only the size of the lymph node, it cannot differentiate the inflammatory disease-related lymph node enlargements from metastasis. In the literature, the sensitivity of thoracic CT was 20%-86%, specificity 50%-93%, PPV 26%-86%, and NPV 40%-93% (10,11). In this study, the sensitivity of thoracic CT was 33%, specificity 82.3%, PPV 25%, and NPV 87.5%.…”

Section: Discussionmentioning

confidence: 61%

Comparative Evaluation of Mediastinal Lymph Nodes in Non-small Cell Lung Cancer with Computed Tomography, 99mTc-MIBI SPECT, and Video-Mediastinoscopy

Önal¹,

Demir²

2017

Erciyes Med J

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Objective: The aim of this study is to evaluate the mediastinal lymph node (MLN) metastasis comparatively with Tc99m-MIBI SPECT scintigraphy, thoracic computed tomography (CT), and video-mediastinoscopy (VM) in the staging of non-small cell lung cancer (NSCLC). Materials and Methods:Forty consecutive patients (36 men, 4 women, average age 59.3 years) who were to undergo surgical treatment for NSCLC between June 2008 and June 2009 were included in this prospective study. All patients underwent chest 99mTc-MIBI SPECT before VM. SPECT results were evaluated visually and semi-quantitatively. Thoracotomy and MLN dissection were applied in patients who did not have MLN metastasis. Results:The MLN involvement was demonstrated in 6 patients via VM. 99mTc-MIBI SPECT correctly staged 5 out of 6 patients, and CT 2 out of 6 patients. The 99mTc-MIBI SPECT showed better results than CT with regard to positive and negative predictive values and accuracy.Conclusion: This study indicates that Tc99m-MIBI SPECT has a better diagnostic value than CT in detecting MLN metastases in NSCLC.Keywords: Lymph nodes, non-small cell lung cancer, technetium-99-m methoxy isobutyl isonitrile Erciyes Med J 2017; 39(4): 154-9 •

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Section: Discussionmentioning

confidence: 61%

Comparative Evaluation of Mediastinal Lymph Nodes in Non-small Cell Lung Cancer with Computed Tomography, 99mTc-MIBI SPECT, and Video-Mediastinoscopy

Önal¹,

Demir²

2017

Erciyes Med J

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“…Lung cancer is the leading cause of cancerrelated death all over the world (%17,8-28) and 85% of lung cancer cases are non-small cell lung cancer (NSCLC) (1). Despite new advances in chemotherapy, radiotherapy and surgical techniques, five-year survival is about 10-15% (1).…”

Section: Introductionmentioning

confidence: 99%

Mediastinoskopi: Küçük Hücreli Dışı Akciğer Kanseri N-Evrelemesinde Hala Geçerli Mi Yoksa Değersiz Bir Yöntem Midir?

Keskin¹,

Baysal²,

Gündüz³

et al. 2020

Osmangazi̇ Journal of Medicine

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This study compares the two most frequently used methods, combined positron emission tomography-computed tomography (PET/CT) and mediastinoscopy, in detecting mediastinal lymph node metastases. It has been investigated whether PET/CT can be used as an alternative method to mediastinoscopy which is considered the gold standard in detecting mediastinal lymph node metastasis. Mediastinal lymph node metastasis is an important factor in treatment and prognosis of non-small cell lung cancer. A total of 102 patients diagnosed with non-small cell lung cancer by our clinic between 2012 and 2017, were enrolled in the study. In total 277 lymph nodes were compared with respect to their histopathologic results and their involvement in positron emission tomography. Specificity value of PET/CT was detected as 84.5% while its negative predictive value, positive predictive value and sensitivity were 82.7%, 69.5% and 66.6%, respectively. In patients who underwent only mediastinoscopy and whose frozen section samples did not demonstrate any metastatic involvement, when histopathological results of lymph node dissection performed by thoracotomy were analyzed, the negative predictive value of mediastinoscopy was calculated as 97%. In total 65 stations including 46 stations smaller than 1 centimeter and 19 stations larger than 1 centimeter, which did not demonstrate any uptake in PET/CT, were sampled. No metastasis was detected in histopathologic staging of these lymph nodes. For patients who do not demonstrate any uptake in mediastinal lymph nodes on PET/CT, invasive lymph node sampling is redundant. However, with the aim of avoiding unnecessary thoracotomies, invasive lymph node sampling is required, even though mediastinal lymph node uptake detected with PET/CT is below the threshold of malignancy.

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Importance of SUVmax threshold in positron emission tomography-computed tomography assessment of mediastinal and hilar lymph nodes in non-small cell lung cancer

Cited by 2 publications

References 13 publications

Comparative Evaluation of Mediastinal Lymph Nodes in Non-small Cell Lung Cancer with Computed Tomography, 99mTc-MIBI SPECT, and Video-Mediastinoscopy

Comparative Evaluation of Mediastinal Lymph Nodes in Non-small Cell Lung Cancer with Computed Tomography, 99mTc-MIBI SPECT, and Video-Mediastinoscopy

Mediastinoskopi: Küçük Hücreli Dışı Akciğer Kanseri N-Evrelemesinde Hala Geçerli Mi Yoksa Değersiz Bir Yöntem Midir?

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