Importance of specific IgM antibodies in 116 patients with various stages of syphilis.

Merlin, Sean; André, Jean; Alacoque, B; Pâris-Hamelin, A.

doi:10.1136/sti.61.2.82

Cited by 19 publications

(10 citation statements)

References 14 publications

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“…A number of studies have suggested that decreasing treponemal IgM levels indicate adequate treatment . The absence of IgM has been demonstrated in 84% of patients with syphilis that were treated in the past . In our study, we obtained similar results, with 83.0% of patients with a past history of syphilis being negative for IgM but positive or equivocal for IgG.…”

Section: Discussionsupporting

confidence: 84%

Comparison of a Combined Nontreponemal (VDRL) and Treponemal Immunoblot to Traditional Nontreponemal and Treponemal Assays

Franken

Oliver

Litwin

2014

Clinical Laboratory Analysis

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The treponemal portion of the ViraBlot IgM/IgG immunoblot compared well with the treponemal confirmation assay and could be a useful supplemental method to fluorescent treponemal antibody or TP-PA for the confirmation of syphilis. The addition of the detection of nontreponemal antibodies to the immunoblot assay, however, may not be of added benefit to the overall assay, due to decreased sensitivity and specificity compared to standard assays.

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Section: Discussionsupporting

confidence: 84%

Comparison of a Combined Nontreponemal (VDRL) and Treponemal Immunoblot to Traditional Nontreponemal and Treponemal Assays

Franken

Oliver

Litwin

2014

Clinical Laboratory Analysis

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“…8 Positive Treponema pallidum specific IgM generally reflects active infection and the treatment is perhaps needed. 8,10,11 In this case, the patient was non-HIV but presented with high RPR titration at 1:256 and positive Treponema pallidum IgM most likely to indicate very active disease.…”

Section: Discussionmentioning

confidence: 85%

Uveitis Presented as a Case of Ocular Syphilis – A Rare Presentation

Wahab¹,

Mustafa

2019

J. Medicine

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Ocular syphilis is one of the clinical presentation or complication of syphilis. Uveitis is the most common ocular diagnosis of the condition but any component of the eyes can be affected. Serology test that include both treponemal and non-treponemal antibody detections play an important role for supporting the diagnosis. This condition is considered as part of neurosyphilis and the recommended treatment follows the treatment for neurosyphilis. We reported a 47-year-old man presented with chronic episode of blurring of vision associated with floaters involving both eyes. Both eyes showed abnormal visual acuity with involvement of optic disc on the left eye. Serology tests for non-treponemal antibody and treponemal antibody test were positive. He was diagnosed as a case of bilateral posterior uveitis with left eye neuroretinitis. He was successfully treated with intravenous aqueous crystalline penicillin 3 million unit every four hour daily for 14 days. J MEDICINE JUL 2019; 20 (1) : 52-54

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“…may acount for these findings. However, Lugar et al (27) and Merlin et al (28) detected these antibodies in practically all the patients they studied, using SPHA. While no patient with active neurosyphilis was included in this survey, IgM-TPHA was detected in the patient with tertiary syphilis.…”

Section: Discussionmentioning

confidence: 97%

Clinical Survey of Syphilis at the Dermatological Clinic of Nippon Medical School Hospital from 1984 to 1988, with Special Reference to the Recent Clinical Manifestations and Evaluation of IgM Antibodies to Treponema pallidum

Ishinaga

Sasaki

1990

The Journal of Dermatology

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One hundred eighty-one patients with syphilis were seen from May 1, 1984, to April 30, 1988 at the Dermatological Clinic of Nippon Medical School Hospital. The incidence of syphilis has increased gradually year by year. The number of early infectious syphilis cases was almost twice as high as late latent syphilis ones. As a source of infection, female prostitutes were noteworthy. Among primary syphilis cases, multiple chancres were observed in 29.2%. The frequency of ulcus durum was much higher than initial sclerosis. A relationship with oral sex is suggested. Among secondary syphilis cases, pruritus was observed in 23.9%, prominently on volar lesions. Psoriasiform papular and macular syphilide were the commonest features. Secondary syphilis with persisting chancres were seen in 41.3% and is gradually increasing. JH reactions were observed in 26.3%. The frequency was highest in late primary and in early secondary stages. IgM-TPHA and IgG-TPHA were tested in 94 sera by gel-filtration and 77 by HPLC. IgM-TPHA tests were reactive in virtually all the sera from untreated syphilis cases. The titres in untreated syphilis were higher than in treated cases. IgM-TPHA/IgM-TPHA + IgG-TPHA was higher in early syphilis than in late syphilis. Fifty-eight untreated cases were tested at frequent intervals after treatment for up to 12 months. IgM antibodies disappeared in 53 patients within 12 months. Non-treponemal antibodies measured by the CF test disappeared within 15 patients and TPHA tests remained positive after 12 months in all patients. IgM-TPHA may support a diagnosis of active syphilis.

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Importance of specific IgM antibodies in 116 patients with various stages of syphilis.

Cited by 19 publications

References 14 publications

Comparison of a Combined Nontreponemal (VDRL) and Treponemal Immunoblot to Traditional Nontreponemal and Treponemal Assays

Comparison of a Combined Nontreponemal (VDRL) and Treponemal Immunoblot to Traditional Nontreponemal and Treponemal Assays

Uveitis Presented as a Case of Ocular Syphilis – A Rare Presentation

Clinical Survey of Syphilis at the Dermatological Clinic of Nippon Medical School Hospital from 1984 to 1988, with Special Reference to the Recent Clinical Manifestations and Evaluation of IgM Antibodies to Treponema pallidum

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