J. Clin. Lab. Anal. volume 29, issue 1, P68-73 2014 DOI: 10.1002/jcla.21730 View full text
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Alicia A. Franken, Joyce H. Oliver, Christine M. Litwin

Abstract: The treponemal portion of the ViraBlot IgM/IgG immunoblot compared well with the treponemal confirmation assay and could be a useful supplemental method to fluorescent treponemal antibody or TP-PA for the confirmation of syphilis. The addition of the detection of nontreponemal antibodies to the immunoblot assay, however, may not be of added benefit to the overall assay, due to decreased sensitivity and specificity compared to standard assays.