Importance of Some Transition Metals and their Biological Role: A Review

Abstract

Transition Metal Chemistry is an international journal which deals with all aspects of the preparation of transition metal-based molecular compounds as well as including their physical, structural, kinetic, catalytic and biological properties, and their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems and more.

Green synthesis of nanosized N,N'-bis(1-naphthylidene)-4,4'-diaminodiphenylmethane and its metal (II) complexes and evaluation of their biological activity

“…1 H-NMR (500 MHz, DMSO-d6, total scan = 80): 10.49 (s br, 2H, 2 × OH), 9.58 (m, 2H, 2 × H-1); 8.50 (m, 2H, Ar H-5, Ar H-5'); 7.90 (m, 2H, Ar H-9, Ar H-9'); 7.74 (m, 2H, Ar H-6, Ar H-6'); 7.55 (m, 2H, Ar H-8, Ar H-8'); 7.50 (m, 8H, Ar H-14, Ar H-14' , Ar-H-16, Ar H-16'); 7.35 (m, 8H, Ar H-13, Ar H-13' , Ar H-17, Ar H-17'); 6.95 (d, 2H, J 9.55 Hz, H-7, H-7'); 6.86 (d, 1H, J 7.65 Hz, Ar H-4); 6.47 (1H, d, J 8.6 Hz, H-4'); 4.86 (s br, 2H, 2 × NH-); 4.00 (s; 2H, -CH 2 ); 3.75 (s, 2H, -CH 2 ), 2.4 (buried) (s, 3H, CH 3 ). MS (EI); m/e (intensity): 1178 (3), 1147 (36), 1125 (23), 1076 (13), 998 (9), 947 (9), 906 (24), 815 (6), 729 (8), 671 (2), 611 (10), 555 (4), 481 (21), 424 (2), 389 (12), 336 (7), 291 (6), 249 (12), 176 (9), 58 (11), 33 (1). Molar conductance (Ω −1 cm 2 mol −1 ): 30, µ eff (B.M.…”

“…for C 61 H 50 N 4 O 6 Co (%); C, 73.71; H, 5.07; N, 5.64; Co, 5.93 Found %, C, 74.12; H, 5.54; N, 5.02; Co, 5.88, IR (KBr, μ cm −1 ): 3466, 1617, 1602,1571,1534,1502,1454,1425,1388,1360,1302,1250,1183,1162,1143,1119,980,872,557,498,452. MS (EI); m/z (intensity): 618 M/2 (18.2), 588 (14.4), 517 (2.4), 438 (1.8), 412 (6.5), 393 (18.8), 378 (11.3), 366 (21.8), 333 (10.6), 322 (99.9), 323 (27.1), 283 (7.4), 250 (17.7), 228 (11.8), 209 (13), 180 (16.7), 136 (8.9), 111 (6.2), 95 (11), 89 (13), 69 (7), 59 (40.3), 57 (24.4), 41 (13.9), 30 (37.7), 18 (22.2). UV-Vis in DMSO: λ max nm (log ɛ) L mol −1 cm −1 ; 323 nm (3.63), 361 nm (2.69), 442 nm (2.65), 470 nm (2.39), 992 nm (0.61).…”

“…For example, copper ions are closely involved in neurodegenerative disorders, especially in Parkinson's disease. Copper (II) complexes possessed various activities such as antiulcer, antiamoebic, antidiabetic, anticonvulsant, anti-inflammatory, antimicrobial and antitumor 7 . Cobalt like copper is an essential trace element for higher organisms.…”

“…Such complexes found activity against leukemia and lymphoma cell lines and bacteria strains. Further biological activity of cobalt complexes involves insulin-like properties, antifungal and antioxidant activity 7 . Zinc is an essential trace element which is found throughout the human body in a variety of tissues, such as skin, bone, liver, muscle, or brain.…”

“…Elevated extracellular levels of zinc lead to the breakdown of the zinc transporting system of the plasma membrane. Zinc complexes exhibited interesting biological activity such as antimicrobial, anti-inflammatory agents, successfully tested for healing zinc-deficient, chronic, and surgical wounds by local administration 7 . In contrast to other transition metals, only trace concentrations of manganese are found in human serum (< 10 nM) and tissue (< 4 μM).…”