Importance of (measuring) the end-systolic volume index in predicting survival

Kerkhof, Peter L. M.; Peace, Richard; Handly, Neal

doi:10.1136/heartjnl-2017-312051

Cited by 5 publications

(3 citation statements)

References 4 publications

(2 reference statements)

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“…We thank Kerkhof et al 1 for their interest in our paper2 and are pleased they agree with our conclusion that accurate determination of end-systolic volume index (ESVI) is important in patients with reduced LVEF.

Table 3 and figure 2 show the entire range of ESVI values.

…”

supporting

confidence: 74%

The authors’ reply to the letter from Kerkhof et al entitled ‘The importance of (measuring) the end-systolic volume index in predicting survival’

Prior¹,

Stevens

Al-Khalidi

et al. 2018

Heart

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Table 3 and figure 2 show the entire range of ESVI values.

…”

supporting

confidence: 74%

The authors’ reply to the letter from Kerkhof et al entitled ‘The importance of (measuring) the end-systolic volume index in predicting survival’

Prior¹,

Stevens

Al-Khalidi

et al. 2018

Heart

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“…Other studies (24) have attempted to interpret in a similar sense the linearized slope of the EF-ESV relationship and confirmed the usefulness via ROC (receiver operating characteristic) analysis, besides focusing on information maximizing component analysis. Recently our laboratory has documented that a linear approach to describe EF vs. ESV may lead to incorrect conclusions, and that a nonlinear approach is warranted (15).…”

Section: Applications Of the Vrgmentioning

confidence: 99%

“…Comparison (P ϭ 0.012) of the VRG regression slope for two groups of pediatric patients, categorized according to 12-mo survival. Also, ESVi alone has been advanced as a strong indicator of survival(15).…”

mentioning

confidence: 99%

Left ventricular volume analysis as a basic tool to describe cardiac function

Kerkhof¹,

Kuznetsova

Ali³

et al. 2018

Advances in Physiology Education

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The heart is often regarded as a compression pump. Therefore, determination of pressure and volume is essential for cardiac function analysis. Traditionally, ventricular performance was described in terms of the Starling curve, i.e., output related to input. This view is based on two variables (namely, stroke volume and end-diastolic volume), often studied in the isolated (i.e., denervated) heart, and has dominated the interpretation of cardiac mechanics over the last century. The ratio of the prevailing coordinates within that paradigm is termed ejection fraction (EF), which is the popular metric routinely used in the clinic. Here we present an insightful alternative approach while describing volume regulation by relating end-systolic volume (ESV) to end-diastolic volume. This route obviates the undesired use of metrics derived from differences or ratios, as employed in previous models. We illustrate basic principles concerning ventricular volume regulation by data obtained from intact animal experiments and collected in healthy humans. Special attention is given to sex-specific differences. The method can be applied to the dynamics of a single heart and to an ensemble of individuals. Group analysis allows for stratification regarding sex, age, medication, and additional clinically relevant covariates. A straightforward procedure derives the relationship between EF and ESV and describes myocardial oxygen consumption in terms of ESV. This representation enhances insight and reduces the impact of the metric EF, in favor of the end-systolic elastance concept advanced 4 decades ago.

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Heart Function Analysis in Cardiac Patients with Focus on Sex-Specific Aspects

Kerkhof¹,

Peace

Heyndrickx

et al. 2018

Advances in Experimental Medicine and Biology

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Cardiac function is best described by investigating the pressure-volume relationships. This information permits description in terms of the ventricular volume regulation graph (VRG), estimation of systolic elastance, evaluation of lusitropic properties, and assessment of ventriculo-arterial coupling. Current techniques yield noninvasive determination of cardiac compartmental volumes, along with systolic/diastolic arterial pressure, while ventricular end-diastolic pressure can be inferred from an echocardiography-based surrogate measure. Ventricular volume is known to vary with age, as well as to be affected by intrinsic cardiac disease and abnormalities of the vascular system. Moreover, 35 years ago it has been shown in healthy adults that left ventricular volume is significantly smaller in women compared to men. This important observation has serious implications for several metrics which are routinely used in clinical practice, e.g., ejection fraction. The remarkable difference between ventricular size in men and women is also a powerful starting point for the study of aging and the investigation of interventions such as exercise. In this review we evaluate sex-specific characteristics of the VRG and the implications for various cardiac patient populations, during basal conditions and intervention such as exercise.

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Importance of (measuring) the end-systolic volume index in predicting survival

Cited by 5 publications

References 4 publications

The authors’ reply to the letter from Kerkhof et al entitled ‘The importance of (measuring) the end-systolic volume index in predicting survival’

The authors’ reply to the letter from Kerkhof et al entitled ‘The importance of (measuring) the end-systolic volume index in predicting survival’

Left ventricular volume analysis as a basic tool to describe cardiac function

Heart Function Analysis in Cardiac Patients with Focus on Sex-Specific Aspects

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