Importance of Investigation of Inflammatory Bowel Disease in China

Li, Xueliang

doi:10.2169/internalmedicine.48.1748

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…As China has undergone rapid industrialization over the past few decades, changes such as Western dietary habits and a more sedentary lifestyle have become the norm; as a result, it has been reported that the incidence and prevalence of IBD in provinces and cities in mainland China is increasing. [17][18][19] It should be noted that, according to Chinese literature and our experience, there are fewer extraintestinal manifestations and complications, and fewer fistulous and perianal complications, but LGIB is a relatively common manifestations for Chinese IBD patients. 20 However, the present study also had some limitations.…”

Section: Discussionmentioning

confidence: 75%

Epidemiology of lower gastrointestinal bleeding in China: Single‐center series and systematic analysis of Chinese literature with 53 951 patients

Bai¹,

Peng²,

Gao³

et al. 2011

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 75%

Epidemiology of lower gastrointestinal bleeding in China: Single‐center series and systematic analysis of Chinese literature with 53 951 patients

Bai¹,

Peng²,

Gao³

et al. 2011

J of Gastro and Hepatol

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Inflammatory bowel disease: beyond the boundaries of the bowel

Actis

Rosina

Mackay

2011

Expert Review of Gastroenterology & Hepatology

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Dysregulated inflammation in the gut, designated clinically as inflammatory bowel disease (IBD), is manifested by the prototypic phenotypes of an Arthus-like reaction restricted to the mucosa of the colon, as in ulcerative colitis, or a transmural granulomatous reaction, as in Crohn's disease, or an indeterminate form of the two polar types. That the inflammation of IBD can trespass the boundaries of the bowel has long been known, with articular, ophthalmologic, cutaneous, hepatobiliary or other complications/associations - some autoimmune and others not - affecting significant numbers of patients with IBD. Also notable is the frequency of diagnosis of IBD-type diseases on a background of systemic, (mostly myelo-hematological) disorders, associated with alterations of either (or both) innate or adaptive arms of the immune response. Finally, cases of IBD are reported to occur as an adverse effect of TNF inhibitors. Bone marrow transplant has been proven to be the only curative measure for some of the above cases. Thus, in effect, the IBDs should now be regarded as a systemic, rather than bowel-localized, disease. Genome-wide association studies have been informative in consolidating the view of three phenotypes of IBD (ulcerative colitis, Crohn's disease and mixed) and, notably, are revealing that the onset of IBD can be linked to polymorphisms in regulatory miRNAs, or to nucleotide sequences coding for regulatory lymphokines and/or their receptors. At the effector level, we emphasize the major role of the Th17/IL-23 axis in dictating the perpetuation of intestinal inflammation, augmented by a failure of physiological control by regulatory T-cells. In conclusion, there is a central genesis of the defects underlying IBD, which therefore, in our opinion, is best accommodated by the concept of IBD as more of a syndrome than an autonomous disease. This altered mindset should upgrade our knowledge of IBD, influence its medical care and provide a platform for further advances.

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Importance of Investigation of Inflammatory Bowel Disease in China

Abstract: The study by Bai et al (1)

Cited by 2 publications

References 15 publications

Epidemiology of lower gastrointestinal bleeding in China: Single‐center series and systematic analysis of Chinese literature with 53 951 patients

Epidemiology of lower gastrointestinal bleeding in China: Single‐center series and systematic analysis of Chinese literature with 53 951 patients

Inflammatory bowel disease: beyond the boundaries of the bowel

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