Importance of effective central nervous system therapy in isolated bone marrow relapse of childhood acute lymphoblastic leukemia. BFM (Berlin- Frankfurt-Munster) Relapse Study Group
Abstract:Presymptomatic central nervous system (CNS) treatment in children with a late isolated first bone marrow (BM) relapse of acute lymphoblastic leukemia (ALL) was based on intermediate-dose systemic and intrathecal (IT) methotrexate (MTX) in the multicenter trial, ALL-REZ BFM 85. Because this was associated with an excess of overt second CNS relapses, cranial radiotherapy (cRT) plus prolonged triple IT therapy with MTX, cytarabine, and prednisone was instituted during the course of the subsequent trial, ALL-REZ B… Show more
“…The patient underwent gastrostomy for tube feeding. Chemotherapy, according to the Berlin‐Frankfurt‐Munster group protocol for relapsed ALL (ALL‐REZ BFM 87) (5), and local irradiation were started immediately.…”
“…The patient underwent gastrostomy for tube feeding. Chemotherapy, according to the Berlin‐Frankfurt‐Munster group protocol for relapsed ALL (ALL‐REZ BFM 87) (5), and local irradiation were started immediately.…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.