Importance of Benzothiazole Motif in Modern Drug Discovery: Introduction

Abstract

Drug discovery & their progress is major interest and present to the entire scientific community is a distilled version of newer developments in medicinal and pharmaceutical research area. Benzothiazoles are the most significant heterocyclic scaffold, which are widespread and integral feature of a broad range of natural occurring molecules and pharmaceutical agents. It shows a number of pharmacophoric activities, and its derivatives signify a high degree of structural diversity that has proven helpful for explore of newer bioactive agents.

Role of Combinatorial, Medicinal & Biological Chemistry in Drug Discovery Development: An Introduction

“…Drug discovery process (Figure 2 & 3) is long, time and money intensive process [1]. This science of has found application in the production of molecules of commercial interest in the construction of newer pharmacological active therapeutic agents derived from rational drug design, into synthesize complex natural molecules, in the finding innovative approaches to render this chemical science more efficient [2,3]. The development of newer pharmaceuticals is currently a critical and challenging task to the pharmaceutical industry.…”

2‐Aminothiazole‐Oxadiazole Bearing N‐Arylated Butanamides: Convergent Synthesis, Tyrosinase Inhibition, Kinetics, Structure‐Activity Relationship, and Binding Conformations

“…These molecules execute several important functions in technology, nature and medicine. An extensive range of properties ever attracted the medicinal and organic chemists to trail the synthesis of innovative designs and screen their pharmacophoric properties [1] . In medicinal chemistry, heterocycles containing nitrogen with sulfur atom are a vital class of compounds [2,5] .…”

“…An extensive range of properties ever attracted the medicinal and organic chemists to trail the synthesis of innovative designs and screen their pharmacophoric properties. [1] In medicinal chemistry, heterocycles containing nitrogen with sulfur atom are a vital class of compounds. [2,5] A heterocyclic compound, thiazole is aromatic five-membered ring encompassing both nitrogen and sulfur atom.…”

Utility of Synthetic, Medicinal and Pharmaceutical Chemistry in Drug Design

“…The process of drug discovery involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials [1][2][3][4][5][6][7]. Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products.…”