Implications of the “Subquantum Level” in Carcinogenesis and Tumor Progression via Scale Relativity Theory

Timofte, Daniel; Eva, Lucian; Vasincu, Decebal; Buzea, Maricel Agop Călin Gh.; Popa, Radu

doi:10.5772/59233

Cited by 1 publication

(1 citation statement)

References 144 publications

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“…Several researchers have indicated that doxorubicin inhibits cancer progression through interaction with DNA of cancerous cells, and thus inhibiting the macromolecular biosynthesis. As such, the replication of cancerous cells is suppressed due to inhibition of the progression of topoisomerase II, which in turn prevents the relaxation of supercoils in DNA, demanded for cell transcription (Daniel Timofte, Lucian Eva, Decebal Vasincu, Călin Gh. Buzea, 2015).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and molecular modelling studies of some 2-pyrazolyl benzofuran derivatives as anti-tumor agents

Sherif¹,

Tawfik²,

Abou-Zeid³

et al. 2022

Delta University Scientific Journal

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Drugs containing benzofuran pyrazole nucleus have been reported to possess antioxidant, antibiofilm, antidiabetic and anti-inflammatory properties. However, there are few debatable studies on the role that this pharmacophoric nucleus can play to elicit antitumor properties. Hence, this study was designed to examine its potential application of benzofuran pyrazole as anticancer drug. For this purpose, a new series of benzofuran pyrazole containing compounds was designed and their antitumor biological activity was assessed using HePG-2, HCT-116, MCF-7 and PC3, respectively. Furthermore, molecular modelling was performed for the investigated compounds to evaluate their recognition profiles at the VEGFR active binding-pocket. Out of this synthesized series, compounds 13 and 18 exhibited the strongest cytotoxic activity against all tumor cell lines with IC50 range between 3.96-5.49 µg/ml.

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Section: Introductionmentioning

confidence: 99%