Drugs containing benzofuran pyrazole nucleus have been reported to possess antioxidant, antibiofilm, antidiabetic and anti-inflammatory properties. However, there are few debatable studies on the role that this pharmacophoric nucleus can play to elicit antitumor properties. Hence, this study was designed to examine its potential application of benzofuran pyrazole as anticancer drug. For this purpose, a new series of benzofuran pyrazole containing compounds was designed and their antitumor biological activity was assessed using HePG-2, HCT-116, MCF-7 and PC3, respectively. Furthermore, molecular modelling was performed for the investigated compounds to evaluate their recognition profiles at the VEGFR active binding-pocket. Out of this synthesized series, compounds 13 and 18 exhibited the strongest cytotoxic activity against all tumor cell lines with IC50 range between 3.96-5.49 µg/ml.
Drugs containing benzofuran pyrazole nucleus have been reported to possess antioxidant, antibiofilm, antidiabetic and anti-inflammatory properties. However, there are few debatable studies on the role that this pharmacophoric nucleus can play to elicit antitumor properties. Hence, this study was designed to examine its potential application of benzofuran pyrazole as anticancer drug. For this purpose, a new series of benzofuran pyrazole containing compounds was designed and their antitumor biological activity was assessed using HePG-2, HCT-116, MCF-7 and PC3, respectively. Furthermore, molecular modelling was performed for the investigated compounds to evaluate their recognition profiles at the VEGFR active binding-pocket. Out of this synthesized series, compounds 13 and 18 exhibited the strongest cytotoxic activity against all tumor cell lines with IC50 range between 3.96-5.49 µg/ml.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.