Implications of the endocannabinoid system and the therapeutic action of cannabinoids in autism spectrum disorder: A literature review

Camargo, Rick Wilhiam de; Júnior, Linério Ribeiro de Novais; Silva, Larissa Mendes da; Meneguzzo, Vicente; Daros, Guilherme Cabreira; Silva, Marina Goulart da; Bitencourt, Rafael Mariano de

doi:10.1016/j.pbb.2022.173492

Cited by 5 publications

(4 citation statements)

References 74 publications

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Section: Resultsmentioning

confidence: 99%

“…57–60 CNS alterations related to ECS in the cerebellum, basal ganglia and hippocampus affect both ASD and ADHD. 57,61,62…”

Section: Resultsmentioning

confidence: 99%

“…Potentially useful biomarkers relating to alterations in ECS components include expression of cannabinoid receptor genes (CNR1, CNR2), which encode the cannabinoid receptors (CB1R and CB2R). [57][58][59][60] CNS alterations related to ECS in the cerebellum, basal ganglia and hippocampus affect both ASD and ADHD. 57,61,62 Table 1 Relevance of copy number variation (CNV) alterations to autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and sleep disruption (SD) in patients with ASD.…”

Section: Petti Et Almentioning

confidence: 99%

“…[57][58][59][60] CNS alterations related to ECS in the cerebellum, basal ganglia and hippocampus affect both ASD and ADHD. 57,61,62 Table 1 Relevance of copy number variation (CNV) alterations to autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and sleep disruption (SD) in patients with ASD. Pathways of nine overlapping CNV clusters relevant to ASD/ADHD/SD are shown, emphasising large contributions that may explain the undue influence of the ADHD cluster on sleep behaviours and SD potentially related to circadian rhythm (Briuglia,…”

Section: Petti Et Almentioning

confidence: 99%

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Management of sleep disorders in autism spectrum disorder with co-occurring attention-deficit hyperactivity disorder: update for clinicians

Petti,

Gupta,

Fradkin

et al. 2023

BJPsych open

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Aims To update and examine available literature germane to the recognition, assessment and treatment of comorbid autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and sleep disruption, with a predominant focus on children, adolescents and emerging adults. Background Considerable overlaps exist among ASD, ADHD and sleep disruption. Literature and guidance for clinicians, administrators, policy makers and families have been limited, as such deliberations were rarely considered until 2013. Method This narrative review of the literature addressing sleep disruption issues among those with ASD, ADHD and comorbid ASD and ADHD involved searching multiple databases and use of reverse citations up to the end of September 2022. Emphasis is placed on secondary sources and relevant data for clinical practice. Results Complex clinical presentations of ASD/ADHD/sleep disruption are frequently encountered in clinical practice. Prior to 2013, prevalence, clinical presentation, pathophysiology, prognosis, other sleep-related factors and interventions were determined separately for each disorder, often with overlapping objective and subjective methods employed in the process. High percentages of ADHD and ASD patients have both disorders and sleep disruption. Here, the extant literature is integrated to provide a multidimensional understanding of the relevant issues and insights, allowing enhanced awareness and better care of this complex clinical population. Database limitations are considered. Conclusions Assessment of ASD symptomatology in youth with ADHD, and the reverse, in cases with disrupted sleep is critical to address the special challenges for case formulation and treatment. Evidence-based approaches to treatment planning and multi-treatment modalities should consider combining psychosocial and biological interventions to address the complexities of each case.

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