The Sustainable Development Goals (SDGs) agreed by Heads of Government in 2015 represent a major multilateral effort to shift the world towards more sustainable and resilient pathways, also taking into account the needs of developing countries. The SDG Agenda calls for a global partnership-at all levels-between all countries and stakeholders who need to work together to achieve the goals and targets, including a broad spectrum of actors such as multinational businesses, local governments, regional and international bodies, and civil society organizations. The purpose of this paper is to present a comprehensive review of the literature and develop a novel framework in order to tackle the barriers and challenges to operationalize and monitor the implementation of the SDGs. To achieve this, this paper reports on a state-of-the-art review of the SDGs, with a particular emphasis on their applications and linkages with sustainability science and aspects of knowledge management. This paper also reviews the rationale and aims of the Sustainable Development Goals, outlines some of the problems and barriers related to their implementation, and presents some areas which deserve future attention. Ultimately, this paper seeks to uncover the various gaps and suggests some means via which some of challenges seen in the accomplishment of the 17 SDGs may be faced.