Implications of metabolic parameters of carbamazepine in the therapeutic monitoring of Tunisian patients with epilepsy

Chbili, Chahra; Hassine, A.; Amor, Sana Ben; Nouira, M.; Ammou, S. Ben; Saguem, Saâd

doi:10.1016/j.neurol.2015.12.010

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Reduction in pain is achieved within 24 hours 6 . CBZ is associated with side effects like drowsiness, dizziness, nausea, vomiting, hepatotoxicity, myelosuppression, aplastic anemia, hyponatremia, renal toxicity, constipation, urinary retention and cardiac dysfunction and decrease in efficacy after prolong use due to auto-induction 7 . Other medical options include drugs like Oxcarbazepine, Lamotrigine, Topiramate, Gabapentin, Baclofen and Phenytoin 8 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Effectiveness of Carbamazepine Versus Topiramate for the Management of Trigeminal Neuralgia

Tariq

Janjua

Mehmood

et al. 2021

PAFMJ

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Objective: To compare the effectiveness of Carbamazepine versus Topiramate for the management of trigeminal neuralgia. Study Design: Comparative prospective study. Place and Duration of Study: Oral and Maxillofacial Surgery department, Allied Hospital, Faisalabad Pakistan, from Nov 2017 to Nov 2018. Methodology: A total of 60 patients (30 in each group) were included. Group A was treated with Carbamazepine 100mg TDS and group B with Topiramate 25mg TDS. Visual analogue scale was used to access pain and was calculated at 1st visit (baseline), at 7th day, at 14th day and at 28th day. Results: Out of 60 patients, mean of age was 54.78 ± 8.49 years. Right and left side of the face was involved in 41 (68.3%) and 19 (31.7%) patients respectively. Maxillary branch was involved in 24 (40%) and mandibular branch was involved in 36 (60%) patients. The mean of visual analogue scale after 7 days in group A was 4.53 ± 0.93 and in group B was 7.1 ± 1.07, after 14 days mean of visual analogue scale in group A was 3.7 ± 1.02 and in group B was 4.03 ± 1.27. Mean of visual analogue scale after 28 days in group A was 3.27 ± 1.01 3.93 ± 1.28. The results were statistically significant with p-value of 0.03. Conclusion: Topiramate has comparable efficacy as that of Carbamazepine at dose of 75-100mg with lesser side effects. So Topiramate can be used as first line of treatment in trigeminal neuralgia.

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Section: Introductionmentioning

confidence: 99%

Comparison of Effectiveness of Carbamazepine Versus Topiramate for the Management of Trigeminal Neuralgia

Tariq

Janjua

Mehmood

et al. 2021

PAFMJ

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Serum monitoring of carbamazepine in patients with epilepsy and clinical implications

Alvarado¹,

Paredes²,

Morales³

et al. 2022

PHAR

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Carbamazepine is a drug with a narrow therapeutic range that requires clinical monitoring, since its toxic effects are not easily predictable, and the therapeutic level can vary. Our study aimed to monitor the serum level and determine the concentration/dose relationship of carbamazepine in people with epilepsy, analyzing its clinical implication. It is observed that 90.48% of the study volunteers present serum level values (4.3–10.4 mg/L) within the therapeutic range (4–12 mg/L); 7.14% present supratherapeutic levels (12.7–14.4 mg/L), 2.38% subtherapeutic (0.93 mg/L). The findings indicate a negative correlation (r = -0.616; r2 = 0.379; p = 0.001), between the dose (mg/day) and the dose ratio (mg/L/mg/day); and a positive correlation (r = 0.544; r2 = 0.296; p = 0.002), between the dose (mg/day)-serum concentration (mg/L). ANOVA and Tukey’s test mean difference is significant (p<0.05). It is concluded that there is a positive and significant linear correlation between daily doses and serum carbamazepine concentrations, which should be considered to individualize the dose and optimize clinical results.

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Implications of metabolic parameters of carbamazepine in the therapeutic monitoring of Tunisian patients with epilepsy

Cited by 2 publications

References 24 publications

Comparison of Effectiveness of Carbamazepine Versus Topiramate for the Management of Trigeminal Neuralgia

Comparison of Effectiveness of Carbamazepine Versus Topiramate for the Management of Trigeminal Neuralgia

Serum monitoring of carbamazepine in patients with epilepsy and clinical implications

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Implications of metabolic parameters of carbamazepine in the therapeutic monitoring of Tunisian patients with epilepsy

Cited by 2 publications

References 24 publications

Comparison of Effectiveness of Carbamazepine Versus Topiramate for the Management of Trigeminal Neuralgia

Comparison of Effectiveness of Carbamazepine Versus Topiramate for the Management of Trigeminal Neuralgia

﻿Serum monitoring of carbamazepine in patients with epilepsy and clinical implications

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Serum monitoring of carbamazepine in patients with epilepsy and clinical implications