Implications of Insulin Resistance / Hyperinsulinemia on Reproductive Function in Infertile Women with Polycystic Ovary Syndrome

Sakumoto, Tetsurou; Tokunaga, Yoshimasa; Terada, Yoko; Tanaka, Hideaki; Nohara, Makoto; Nakaza, Aritoshi; Higashi, Masahiro

doi:10.5772/25987

Cited by 4 publications

(6 citation statements)

References 67 publications

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“…31 In another study elevated circulating androgen (including free testosterone) levels were observed in 80-90% of PCOS women with oligomenorrhea. 25 In the present study serum ferritin were found positive weakly correlated with total testosterone. Finding of present study regarding presence hyperandrogenism was not consistent with previous findings.…”

Section: Discussionsupporting

confidence: 60%

Association of serum ferritin with insulin resistance in women with polycystic ovarian syndrome

Begum

Ishra

Sharifa

et al. 2021

Int J Reprod Contracept Obstet Gynecol

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Background: Emerging scientific evidence has disclosed unsuspected influences between iron metabolism, insulin resistance and type 2 diabetes. Even mildly elevated body iron stores are associated with statistically significant increases in glucose homeostasis indices. But till now high serum ferritin associated with type 2 diabetes is not recognized as an entity in the current clinical guidelines for the management of type 2 diabetes.Methods: This was a Cross sectional study carried out from September 2016 to March, 2017 at PCO clinic of infertility outpatient department (OPD), department of obstetrics and gynecology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study population consisted of all the diagnosed PCOS patients. Purposive sampling Main outcome variable: serum ferritin level and insulin resistance index (Homeostatic model assessment of insulin resistance: HOMA-IR).Results: Most of the (90.9%) patients were aged 20-30 years having BMI >25 kg/m2, mostly overweight (52.53%) or obese (25.25%). Significant increase of serum ferritin level (72.89±34.97; p=0.001) was noted in PCOS patients with insulin resistance. Marked increase in serum ferritin (82.81±31.57, p<0.001), fasting serum insulin (16.39±7.1; p<0.001), HOMA-IR (3.51±1.55; p<0.001) and more cases with insulin resistance (78.3%; p<0.001) were found in women with high ferritin level (when ≥45.5 ng/ml). Statistically significant strong positive correlation between serum ferritin level and fasting insulin level (r=0.528; p<0.001) as well as HOMA-IR (r=0.492; p<0.001) were observed.Conclusions: These results demonstrated that elevated level of serum ferritin was associated with insulin resistance in PCOS women.

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Section: Discussionsupporting

confidence: 60%

Association of serum ferritin with insulin resistance in women with polycystic ovarian syndrome

Begum

Ishra

Sharifa

et al. 2021

Int J Reprod Contracept Obstet Gynecol

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“…Insulin resistance and hyperinsulinaemic are common clinical presentations in women with PCOS [17]. This clearly indicates that insulin metabolism impairment in PCOS women [16]. Impairment of insulin will directly effect on follicular development and steroidogenesis which may interfere with physiology of ovarian function.…”

Section: Discussionmentioning

confidence: 99%

“…Increased androgen production by ovarian cells is the cause of the classical endocrine phenotype of PCOS. Although the exact mechanism of TNF-α in the pathogenesis of hyperandrogenism is still not clear, increased TNF-α in adipose and muscle tissue has been proposed to involve insulin resistance in humans [13]- [16]. Insulin resistance and hyperinsulinaemic are common clinical presentations in women with PCOS [17].…”

Section: Discussionmentioning

confidence: 99%

The Relevance of Genetic Polymorphism of CYP1A1, ICAM-1, TNF-α and INSR Genes in Women with Polycystic Ovary Syndrome (PCOS)

Hazwanie¹,

Gan²,

Nalliah³

2015

JOMB

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Polycystic Ovarian Syndrome (PCOS) is a complex endocrine disorder commonly seen in about 6.5-8% of women of reproductive age. Polygenic trait is common in PCOS and various factors related to the androgenic pathways and the metabolic syndrome have been studied including genes encoding inflammatory cytokines. In this respect we aimed to study the involvement of polymorphisms of four genes; cytochrome P450 1A1 (CYP1A1), intercellular adhesion of molecule (ICAM-1), tumour necrosis factor alpha (TNF-α) and insulin receptor gene (INSR). Twelve women fulfilling the criteria of PCOS and 145 controls were recruited. In this study, TNF-α-1031 (T/C) (rs1799964) is found to be significantly higher in PCOS group compared to healthy controls (OR = 5.044; CI: 2.139-11.899; p-value < 0.05). This suggests TNF-α-1031 (T/C) appears to be a potential candidate as a molecular marker in determining PCOS risk. This study also found a strong association between PCOS and obesity (BMI>25); obesity is a major risk factor of PCOS. Studies of association enables clinicians to have a better understanding of the genetic factors for PCOS especially in a multi-ethnic population such as Malaysia, where robust data addressing PCOS are still lacking.  Index Terms-polycystic ovarian syndrome (PCOS), polymorphism, single nucleotide polymorphisms (SNPs)

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“…The central role of iron in biology can be understood by the fact that iron is the fourth most abundant element in Earth's crust as well as the transition element, most abundant in all living organisms including human being.5 Iron induced cell oxidative stress can explain some extent of its association with abnormal insulin sensitivity. [12][13][14][15][16][17][18][19][20] On the other hand, it is well established that there is increased NIDDM among women with PCOS that has been ascribed to the insulin resistance characteristic of PCOS.11,17,22,33 Serum ferritin levels are also found to be increased in PCOS, suggesting mild iron overload.1,2,3,26 Therefore there is a possibility that increased iron status of PCOS patients is an associated feature with insulin resistance syndrome. A total of 99 previously diagnosed PCOS patients were included in this study maintaining selection criteria.…”

Section: Discussionmentioning

confidence: 99%

“…6,15 The first and clearest evidence for a relation between iron and human diabetes was observed in individuals with pathologic iron overload like hereditary hemochromatosis (HH), and later on also with transfusional iron overload. 16,[17][18][19][20] The aim of the current study was comparing the levels of Serum Fasting blood glucose level, insulin resistance, Serum Thyroid stimulating hormone level, Serum Ferritin level and Serum Gama amino butyric acid level in diagnosed polycystic ovarian syndrome patients and normal controls and also to analyze the Pearson Correlation Coefficient between Variables of Ferritin, HOMA IR with TSH, and GABA in women with Polycystic Ovarian Syndrome Subjects.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of serum fasting blood glucose level, insulin resistance, serum thyroid stimulating hormone level, serum ferritin level and serum gama amino butyric acid level in diagnosed polycystic ovarian syndrome patients

Choudhary¹,

Bansal²,

Chauhan³

et al. 2023

ijhs

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Aim and Objective: To evaluate to evaluate the levels of Serum Fasting blood glucose, IR, Serum TSH, Serum Ferritin and Serum GABA in diagnosed PCOS patients and normal controls. Methods: The study was conducted on 160 subjects aged between 18 to 45 years comprising of 80 healthy control and 80 patients with clinically diagnosed cases of PCOS, acted as study group. The blood samples of controls as well as study groups were withdrawn and Clinical evaluation included anthropometry, Height, Weight, Body Mass Index (BMI) and waist-to-hip ratio (WHR) were calculated. Circulating levels of fasting glucose, insulin resistance, Serum Thyroid stimulating hormone level, Serum Ferritin level and Serum Gama amino butyric acid level were determined by Chemiluminescence based immunoassay (CLIA) on fully automated Biochemistry analyzer MAGLUMI 1000. Results: Total 160 subjects with both control and study group PCOS patients were included in the study. The age of these control group was ranged from 18 to 45 years, with a mean of 26.23±5.58 years and PCOS study were found 27.76 ±6.54 years. The findings of anthropometric measurements of the subjects of both PCOS syndrome (n=80) and non-PCOS (n=80).

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Implications of Insulin Resistance / Hyperinsulinemia on Reproductive Function in Infertile Women with Polycystic Ovary Syndrome

Cited by 4 publications

References 67 publications

Association of serum ferritin with insulin resistance in women with polycystic ovarian syndrome

Association of serum ferritin with insulin resistance in women with polycystic ovarian syndrome

The Relevance of Genetic Polymorphism of CYP1A1, ICAM-1, TNF-α and INSR Genes in Women with Polycystic Ovary Syndrome (PCOS)

Comparative study of serum fasting blood glucose level, insulin resistance, serum thyroid stimulating hormone level, serum ferritin level and serum gama amino butyric acid level in diagnosed polycystic ovarian syndrome patients

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