2020
DOI: 10.1016/s2468-1253(20)30076-5
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Implications of COVID-19 for patients with pre-existing digestive diseases

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Cited by 301 publications
(284 citation statements)
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“…Autopsy studies are needed to understand the digestive system involvement of COVID-19; however, to date, there has been only one autopsy report for an 85-year-old man with COVID-19, which showed segmental dilatation and stenosis in the small intestine [47]. Whether this finding is secondary to COVID-19 is unknown [48].…”
Section: Covid-19 and The Gastrointestinal Tractmentioning
confidence: 99%
See 2 more Smart Citations
“…Autopsy studies are needed to understand the digestive system involvement of COVID-19; however, to date, there has been only one autopsy report for an 85-year-old man with COVID-19, which showed segmental dilatation and stenosis in the small intestine [47]. Whether this finding is secondary to COVID-19 is unknown [48].…”
Section: Covid-19 and The Gastrointestinal Tractmentioning
confidence: 99%
“…This may have implications for the management of patients with pre-existing digestive diseases [52]. Patients with cancer are more susceptible to infection, however, whether patients with gastrointestinal cancers are more likely to be infected with SARS-CoV-2 than healthy individuals remains unknown [48]. In a nationwide analysis from China, 18 (1%) of 1590 COVID-19 cases had a history of cancer.…”
Section: Covid-19 and Pre-existing Digestive Diseasesmentioning
confidence: 99%
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“…However, initial results have highlighted the impact of cardiovascular and pulmonary comorbidities [10] rather than that of possible immunosuppression, leading some to even consider a protective role for immunosuppressive drugs in severe pneumonia [11][12][13]. The limited information currently available comes from a Chinese cohort of 20,000 patients with chronic inflammatory bowel diseases, and from 3 hospitals in Wuhan: no cases of infected patients have been reported [14]. The mystery remains.…”
Section: What Did We Know?mentioning
confidence: 99%
“…sobre el hĂ­gado, si bien se ha valorado la posibilidad de que este virus podrĂ­a ocasionar un daño directo en los conductos biliares intrahepĂĄticos(6).Las interacciones y los efectos del SARS-CoV2 en el esĂłfago, el estĂłmago, el ĂĄrbol biliar y el pĂĄncreas no se han notificado en la actualidad, pero podrĂ­an aparecer en la literatura a su debido tiempo, a medida que se vayan mejorando los mĂ©todos de detecciĂłn(7).Aparte de la afectaciĂłn del aparato digestivo por el nuevo coronavirus, no son menos importantes las implicaciones que COVID-19 puede tener en pacientes con alguna enfermedad digestiva preexistente(8).Se ha observado que los pacientes con COVID-19 y cĂĄncer tienen un mayor riesgo de eventos graves(9).Por otro lado, dado el uso frecuente de fĂĄrmacos biolĂłgicos (infliximab,adalimumab) e inmunosupresores (azatioprina, mercaptopurina) en pacientes con enfermedad inflamatoria intestinal (EII), se tiene cierta preocupaciĂłn de que puedan ser mĂĄs susceptibles a la infecciĂłn por SARS-CoV-2, si bien todavĂ­a no se ha comunicado ningĂșn infectado por este virus en una cohorte de mĂĄs de 20.000 Page 4 of 6 J o u r n a l P r e -p r o o f 4/6pacientes chinos con EII(10). Pese a ello, los chinos ya han implementado varias estrategias para minimizar el riesgo potencial de infecciĂłn por SARS-CoV-2 en pacientes con EII, entre otras, una guĂ­a de prĂĄctica clĂ­nica propia(11).En fin, que el aparato digestivo tambiĂ©n parece afectarse en el COVID-19, tanto de novo, como cuando hay patologĂ­a digestiva previa, hechos que deberemos de tener en cuenta en el manejo de esta nueva enfermedad emergente.Es vox populi que los "chinos copian casi todo", pero, en esta pandemia de COVID-19, estĂĄn haciendo las cosas, al menos desde el punto de vista sanitario, bastante bien, por lo que no es ningĂșn demĂ©rito copiarles ahora a ellos.El autor declara no tener conflicto de interĂ©s.…”
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