Hepatic and gastrointestinal involvement in coronavirus disease 2019 (COVID-19): What do we know till now?

Musa, Sherief

doi:10.1016/j.ajg.2020.03.002

Cited by 140 publications

(214 citation statements)

References 58 publications

Supporting

Mentioning

182

Contrasting

Unclassified

Order By: Relevance

“…Another important issue is the health education for personnel regarding the infection control measures and needed precautions for suspect and probable COVID-19 patients. 9 However; numerous uncertainties are still present concerning patient safety, methods for protecting health care providers, and how to avoid nosocomial infection in emergency endoscopic settings.…”

Section: Introductionmentioning

confidence: 99%

Emergency endoscopic variceal band ligation in a COVID‐19 patient presented with hematemesis while on mechanical ventilation

Kassas

Shafie

Hameed

et al. 2020

Digestive Endoscopy

View full text Add to dashboard Cite

COVID‐19, caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2), is now a global pandemic with serious health consequences. Currently, many strict control measures are applied in health care settings, including endoscopy units, in order to limit virus spread. Several recommendations called to limit endoscopic procedures to emergent endoscopies; however, several uncertainties still exist concerning patient safety, protective measures, and infection control methods in emergency endoscopic settings. In this case report, we present a case of successful endoscopic band ligation for bleeding esophageal varices in man with COVID‐19 disease who presented with an acute attack of hematemesis while on mechanical ventilation (MV). Esophago‐gastroduodenoscopy was performed in the ICU room after preparing the setting, and revealed large, risky esophageal varices. Endoscopic band ligation was done with successful control of bleeding. Third‐level measures of medical protection were applied for the participating medical personnel, and patient monitoring was maintained all through the procedure. After the procedure, the bleeding stopped, and the patient was vitally stable and conscious. We conclude that emergency endoscopic interventions could be performed safely with appropriate arrangements in patients with confirmed COVID‐19 on MV.

show abstract

Section: Introductionmentioning

confidence: 99%

Emergency endoscopic variceal band ligation in a COVID‐19 patient presented with hematemesis while on mechanical ventilation

Kassas

Shafie

Hameed

et al. 2020

Digestive Endoscopy

View full text Add to dashboard Cite

show abstract

“…With respect to SARS-CoV-2 infected patients with endoscopic examinations, GI bleeding was the main indication for endoscopy in our center, thus reflecting our restrictive policy to only conduct emergency endoscopies in these patients [ 11 ]. In our center 16 endoscopic interventions were done in 9 COVID-19 patients.…”

Section: Discussionmentioning

confidence: 99%

Impact of the COVID-19 pandemic on an interdisciplinary endoscopy unit in a German “hotspot” area: a single center experience

Wichmann¹,

Atique

Stüker³

et al. 2020

Surg Endosc

View full text Add to dashboard Cite

Background and study aims Since December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19), has posed a pandemic threat to global health and has challenged health care system in all affected countries. Patients and methods This is a combined study including a descriptive part about the changes in the daily work routine of an Interdisciplinary Endoscopic Unit (IEU) and a prospective analysis of patients tested positive for SARS-CoV-2 who required endoscopic interventions. Conclusively, we present the finding of a point-prevalence analysis in the staff of the IEU. Results We present effects of the COVID-19-related restructuring of processes in our interdisciplinary endoscopy unit (IEU) with respect to cancelation of examinations, relocation of staff to other departments, impact of SARS-CoV-2 on medical staff of the IEU, and supply of protective clothing. Additionally, we analyzed the cohort of COVID-19 patients: Sixteen endoscopic interventions were done in ten patients. In all patients with confirmed infection with SARS-CoV-2, emergency endoscopies were required for relevant bleeding situations. Re-endoscopies were required only in critically ill COVID-19 patients. Conclusions The restructuring of processes in the IEU was feasible in short time, effective, and can also be applied broadly at least in developed countries [Garbe et al. in Gastroenterology 159:778–780, 2020; Repici A, Pace F, Gabbiadini R, Colombo M, Hassan C, Dinelli M, Group IG-CW, Maselli R, Spadaccini M, Mutignani M, Gabbrielli A, Signorelli C, Spada C, Leoni P, Fabbri C, Segato S, Gaffuri N, Mangiavillano B, Radaelli F, Salerno R, Bargiggia S, Maroni L, Benedetti A, Occhipinti P, De Grazia F, Ferraris L, Cengia G, Greco S, Alvisi C, Scarcelli A, De Luca L, Cereatti F, Testoni PA, Mingotto R, Aragona G, Manes G, Beretta P, Amvrosiadis G, Cennamo V, Lella F, Missale G, Lagoussis P, Triossi O, Giovanardi M, De Roberto G, Cantu P, Buscarini E, Anderloni A, Carrara S, Fugazza A, Galtieri PA, Pellegatta G, Antonelli G, Rosch T, Sharma P (2020) Endoscopy units and the COVID-19 Outbreak: a Multi-Center Experience from Italy. Gastroenterology;]. The endoscopy-related rate of SARS-CoV-2 infection of staff is low, but supply of protective equipment is crucial for this. Endoscopic procedures in COVID-19 patients were not directly related to SARS-CoV-2 infection, but to other underlying diseases or typical complications of long-term ICU treatment.

show abstract

“…In liver, virus-induced cytopathic effects leads to liver injury ranging from 14.8 to 78% of infected cases, mainly presenting with abnormal levels of alanine aminotransferase (ALT) and aspartate aminotransferase accompanied by slightly elevated bilirubin levels. 29 Nausea or vomiting, or both, and diarrhea were reported as gastrointestinal manifestations. Adult patients with COVID-19 may experience cardiac injury and arrhythmia; however, these symptoms are infrequently reported in children, but renal failure was found in one child.…”

Section: Extrapulmonary Manifestationmentioning

confidence: 99%

COVID-19 in Children: Present and Future Perspective, An Interim Review

Patnaik

Behera

Nayak

et al. 2020

Journal of Child Science

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. However, the mechanism by which the pathogen affects children is not understood completely. Children so far accounted for only1 to 6.4% of diagnosed cases and the mortality rate is also less. Though clinical findings are similar to adults, with fever and respiratory symptoms being prevalent, fewer numbers of children appear to develop severe pneumonia. Observed attenuated response to the virus may possibly be due to decrease in the expression of the angiotensin-converting enzyme 2 receptor in lungs, repeated viral exposure, and not having any underlying chronic diseases or immunosuppression. Suggested treatment included oxygen supplementation, mechanical ventilation in severe cases, nutritional support, and maintaining fluids and electrolyte balances. Although, no definitive pharmacological therapy is available, various combination of drugs like hydroxychloroquine, lopinavir/ritonavir, remdesivir, tocilizumab, and convalescent serum show promising result to an extent. As there is no specific therapeutic measure for this ailment, aggressive efforts are being made to develop a potential vaccine against the disease. Although few reports on epidemiology of COVID-19 in children have been published, comprehensive reports are lacking. The present article reviews on important issues such as epidemiological characteristics, postulations of milder disease, therapeutic aspect, and recent development of vaccination against COVID-19 in children.

show abstract

Hepatic and gastrointestinal involvement in coronavirus disease 2019 (COVID-19): What do we know till now?

Cited by 140 publications

References 58 publications

Emergency endoscopic variceal band ligation in a COVID‐19 patient presented with hematemesis while on mechanical ventilation

Emergency endoscopic variceal band ligation in a COVID‐19 patient presented with hematemesis while on mechanical ventilation

Impact of the COVID-19 pandemic on an interdisciplinary endoscopy unit in a German “hotspot” area: a single center experience

COVID-19 in Children: Present and Future Perspective, An Interim Review

Contact Info

Product

Resources

About