Implications of blood type for ovarian reserve

Nejat, Edward J.; Jindal, Sangita; Berger, David; Büyük, Erkan; Lalioti, Maria D.; Pal, Lubna

doi:10.1093/humrep/der199

Cited by 38 publications

(62 citation statements)

References 30 publications

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“…Based on our earlier findings [5], we hypothesized a higher oocyte yield, and possibly better clinical pregnancy rates following IVF in women of blood type A compared to those with blood type O. This study builds upon our prior observation that if indeed blood type relates to the status of ovarian reserve in infertile women, then blood type may also relate to ovarian response to exogenous gonadotropins and to IVF cycle outcome.…”

Section: Introductionmentioning

confidence: 73%

“…Based on our earlier work [5] we anticipated a higher prevalence of blood type O amongst women with DOR.…”

Section: Resultsmentioning

confidence: 99%

“…Notably, this study population is distinct from that reported previously [5]. Patient characteristics including age, body mass index (BMI), self-identified race and ethnicity, infertility diagnosis, blood type and Rh status, early follicular phase serum FSH (IU/L) and estradiol (E 2, pg/mL) were collected.…”

Section: Methodsmentioning

confidence: 99%

“…Cycle parameters such as cycle attempt (first versus repeat IVF), (type [intracytoplasmic Sperm Injection -ICSI, versus IVF), dose and duration of gonadotropin stimulation, E 2 on day of HCG trigger, number of eggs retrieved and number of embryos transferred were identified. FSH levels >10 IU/L was considered consistent with DOR in agreement with common practice guidelines at both study sites [5]. Live birth (LB) following fresh embryo transfer (ET) and FSH >10 IU/L were the primary and secondary outcomes of interest respectively whereas blood type constituted the independent variable of interest.…”

Section: Methodsmentioning

confidence: 99%

“…A study in the US found that infertile patients with endometriosis had a higher prevalence of blood type A compared to blood type O [4]. In a previous study of reproductive age infertile women, we had observed that women with blood type O were twice as likely to manifest evidence of diminished ovarian reserve (DOR) as defined by baseline early follicular phase FSH level of >10 IU/L, compared to those with blood types A or AB [5]. The presence of 'A' blood group antigen (i.e., blood types A or AB) was observed to relate with a reduced likelihood for DOR, an association that was independent of age.…”

Section: Introductionmentioning

confidence: 97%

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Blood type predicts live birth in the infertile population

Goldsammler

Jindal

Kallen

et al. 2015

J Assist Reprod Genet

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Purpose To determine if blood type in infertile women relates to the likelihood for live birth (LB) following IVF, and to the etiology for infertility. Methods Retrospective study of patients undergoing IVF at two academic centers in the northeast US. Relationships between blood type (A, B, AB, O) and patient characteristics, IVF cycle parameters and LB were assessed utilizing multivariable logistic regression analyses. Results In the studied population (n=626), women with type O were significantly more likely to have baseline FSH>10 IU/L after adjusting for age, BMI and race (OR 5.09, 95 % CI 1.4-18.7, p=0.01). Conversely, women with blood type A were significantly more likely to have ovulatory infertility compared to those with blood type O after adjusting for age and BMI (OR 3.2, 95 % CI 1.7-6.2). Blood type B was associated with increased likelihood of live birth (OR 1.9, 95 % CI 1.10-3.41, p=0.03) after adjusting for factors recognized to impact IVF outcome. Conclusion Ovulatory infertility and baseline FSH>10 IU/L were more prevalent in women with blood type A and O respectively. However, those of blood type B had significantly higher odds for LB compared to other blood types after adjusting for factors recognized to impact on IVF cycle outcome. While underlying mechanisms are unclear, for infertile women, patient's blood type is seemingly relevant for IVF cycle outcome.

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Section: Introductionmentioning

confidence: 73%

“…Based on our earlier work [5] we anticipated a higher prevalence of blood type O amongst women with DOR.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Blood type predicts live birth in the infertile population

Goldsammler

Jindal

Kallen

et al. 2015

J Assist Reprod Genet

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Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET

Huang

Zhang

et al. 2018

Arch Gynecol Obstet

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PurposeThe occurrence of diminished ovarian reserve (DOR) in women was growing in recent years. Although in vitro fertilization and embryo transfer (IVF-ET) became an effective treatment for DOR, the live-birth (LB) rate remains unsatisfactory. This study aimed to investigate the impact factors of LB rate in women with DOR undergoing assisted reproduction.MethodsThis was a single-center retrospective cohort study. A total of 2277 IVF-ET or ICSI cycles from 1957 DOR women were analysed. Impact factors of LB rate were explored via Student’s t test, Pearson’s Chi-square test, and multivariate logistic regression models.ResultsThere were statistically significant differences in maternal age (P < 0.001), duration of infertility (P < 0.001), female body mass index (P = 0.039), first IVF cycle (P = 0.004), poor ovarian response (P < 0.001), paternal age (P < 0.001), total gonadotropin dose (P = 0.010), endometrial thickness (P = 0.021), number of follicles ≥ 14 mm (P = 0.007), number of oocytes retrieved (P < 0.001), number of frozen embryos (P = 0.014), and the stage (P < 0.001) and number (P < 0.001) of embryos transferred between the non-live-birth (NLB) and LB groups. However, only factors of maternal age, the stage and number of embryos transferred remained different after adjusting for potential confounders.ConclusionsMaternal age, the stage and number of embryos transferred were independent impact factors affecting the live-birth rate in women with DOR seeking for assisted conception.

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