Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET

Huang, Yun; Li, Jingyi; Zhang, Fang; Liu, Yifeng; Xu, Gufeng; Guo, Jun; Zhang, Runjv; Wu, Yiqing; Liu, Juan; Chen, Kai; Zhao, Wei; Wu, Wei; Hu, Yan-Jun; Chen, Guangdi; Zhang, Dan

doi:10.1007/s00404-018-4884-4

Cited by 27 publications

(16 citation statements)

References 35 publications

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“…In a cohort of couples with unexplained infertility and advanced female age, only age was found to be a clear predictor of live birth after IVF, further confirming the intrinsic awareness of every IVF expert: the age of the egg is what really matters. This conclusion is in agreement with what has already been reported in previous studies [23,28,29].…”

Section: Discussionsupporting

confidence: 94%

Women in Advanced Reproductive Age: Are the Follicular Output Rate, the Follicle-Oocyte Index and the Ovarian Sensitivity Index Predictors of Live Birth in an IVF Cycle?

Carosso¹,

Eekelen

Revelli³

et al. 2022

JCM

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(1) Background: Several researchers have investigated alternative markers related to ovarian responsiveness in order to better predict IVF outcomes, particularly in advanced reproductive-aged women. The follicular output rate (FORT), the follicle-oocyte index (FOI) and the ovarian sensitivity index (OSI) are among the most promising. However, these three metrics have not been investigated as independent predictors of live birth in women of advanced reproductive age; neither have they been compared to the two ‘component’ characteristics that are used to calculate them. (2) Methods: A logistic regression model containing all relevant predictors of ovarian reserve or response was used to evaluate the potential of FORT, FOI and OSI as predictors of live birth. After, the non-linear associations between FORT, FOI and OSI and the probability of live birth were evaluated. Finally, we fitted multiple logistic regression models to compare whether FORT, FOI and OSI were more informative predictors than their components. (3) Results: 590 couples received a total of 740 IVF cycles, after which, 127 (17.5%) obtained a live birth. None of FORT, FOI and OSI showed a strength of association or a p-value even close to female age (odds ratio for live birth (95% confidence interval) 1.00 (0.99–1.01), 1.00 (0.99–1.01), 0.98 (0.88–1.11) and 0.58 (0.48–0.72), respectively). The three models comparing FORT, FOI and OSI with the number of oocytes retrieved, the AFC, the number of preovulatory follicles and the FSH total dose were not more informative. (4) Conclusions: In a population of women of advanced age with unexplained infertility, none of FORT, FOI and OSI were predictive of live birth or more predictive than the two ‘component’ characteristics that were used to calculate them. We suggest clinicians and researchers still use female age as the most reliable predictor of an IVF treatment.

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Section: Discussionsupporting

confidence: 94%

Women in Advanced Reproductive Age: Are the Follicular Output Rate, the Follicle-Oocyte Index and the Ovarian Sensitivity Index Predictors of Live Birth in an IVF Cycle?

Carosso¹,

Eekelen

Revelli³

et al. 2022

JCM

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show abstract

“…They observed significant differences between cycles ended either with live birth or not for the parameters of maternal and paternal age, body mass index, poor ovarian response, TOC, number of transferred embryos. They emphasized that maternal age and number of embryos transferred were independent factors affecting live birth rate [22]. Our results differed from those of Huang et al This difference may arise from our small population.…”

Section: Discussioncontrasting

confidence: 90%

What is the effect of the early follicular phase FSH/LH ratio on the number of mature oocytes and embryo development?

Arat¹,

Deveci²,

Özkan³

et al. 2020

Turk J Med Sci

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Background/aim: Basal level of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and antral follicle count are used as predictors of ovarian reserve before starting ovulation induction. We aimed to investigate the predictor potential of early follicular phase FSH/LH ratio on controlled ovarian hyperstimulation-intracytoplasmic sperm injection (COH-ICSI) cycle outcomes. Materials and methods: This retrospective cohort study was conducted with 648 COH-ICSI cycles performed between 2012 and 2014. Cycles were classified according to their basal FSH/LH ratio, group 1(G1) = FSH/LH ratio < 2, N = 473 and group 2(G2) = FSH/LH ratio ≥ 2, N = 175. Demographic characteristics and stimulation parameters were evaluated. Retrieved total oocyte count (TOC), mature oocyte count (MOC), transferred embryo number, and pregnancy results were obtained and transferred to computer by SPSS 21.0 programme. Results: TOC and MOC of G1 were significantly higher than those of G2. The total gonadotrophin doses of G2 were significantly higher than G1. There was no significant difference between groups for transferred embryo number. Pregnancy and live birth rates were similar in both groups. Conclusion: In our population, increased FSH/LH ratio did not affect the rates of pregnancy and live birth negatively.

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“…Furthermore, endMSC-EVs were also verified to improve in vitro fertilization (IVF) outcome in aged murine model ( 49 ). IVF-embryo transfer (IVF-ET) was widely applied in POI patients for assisted conception ( 99 ). Perhaps IVF-ET combined with MSC-EVs might be a new method for helping POI patients to conceive, although the safety to offspring needs to be explored.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Female Reproductive Diseases

et al. 2021

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Reproductive disorders, including intrauterine adhesion (IUA), premature ovarian insufficiency (POI), and polycystic ovary syndrome (PCOS), are great threats to female reproduction. Recently, mesenchymal stem cells derived–extracellular vesicles (MSC-EVs) have presented their potentials to cure these diseases, not only for the propensity ability they stemmed from the parent cells, but also for the higher biology stability and lower immunogenicity, compared to MSCs. EVs are lipid bilayer complexes, functional as mediators by transferring multiple molecules to recipient cells, such as proteins, microRNAs, lipids, and cytokines. EVs appeared to have a therapeutic effect on the female reproductive disorder, such as repairing injured endometrium, suppressing fibrosis of endometrium, regulating immunity and anti-inflammatory, and repressing apoptosis of granulosa cells (GCs) in ovaries. Although the underlying mechanisms of MSC-EVs have reached a consensus, several theories have been proposed, including promoting angiogenesis, regulating immunity, and reducing oxidate stress levels. In the current study, we summarized the current knowledge of functions of MSC-EVs on IUA, POI, and PCOS. Given the great potentials of MSC-EVs on reproductive health, the critical issues discussed will guide new insights in this rapidly expanding field.

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Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET

Cited by 27 publications

References 35 publications

Women in Advanced Reproductive Age: Are the Follicular Output Rate, the Follicle-Oocyte Index and the Ovarian Sensitivity Index Predictors of Live Birth in an IVF Cycle?

Women in Advanced Reproductive Age: Are the Follicular Output Rate, the Follicle-Oocyte Index and the Ovarian Sensitivity Index Predictors of Live Birth in an IVF Cycle?

What is the effect of the early follicular phase FSH/LH ratio on the number of mature oocytes and embryo development?

Therapeutic Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Female Reproductive Diseases

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