Implications of a highly transmissible variant of SARS-CoV-2 for children

Ratmann, Oliver; Bhatt, Samir; Flaxman, Seth

doi:10.1136/archdischild-2021-321903

Cited by 9 publications

(6 citation statements)

References 5 publications

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“…A large study of children and adolescents hospitalized for COVID-19 or MISC-C also showed that 22 % had neurologic involvement, raising concern for neuroinvasion and locally incited neuroinflammation ( LaRovere et al, 2021 ). Finally, the emergence of the highly transmissible SARS-CoV-2 B117 strain has generated growing concern that pediatric infection rates will rise, particularly as schools continue to re-open ( Ratmann et al, 2021 ).…”

Section: Neuroinvasion and Inflammation In Covid-19mentioning

confidence: 99%

Viral respiratory infections and psychosis: A review of the literature and the implications of COVID-19

Kulaga

Miller

2021

Neuroscience & Biobehavioral Reviews

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Section: Neuroinvasion and Inflammation In Covid-19mentioning

confidence: 99%

Viral respiratory infections and psychosis: A review of the literature and the implications of COVID-19

Kulaga

Miller

2021

Neuroscience & Biobehavioral Reviews

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“…5 Today, more attention has been drawn on pediatric transmission due to an increased number of cases and the emergence of new variants of the virus. 6,7 Initial studies conducted early in the pandemic regarded children as the 'silent spreaders' of SARS-CoV-2 due to the higher rate of asymptomatic COVID-19 infection in the pediatric population than that reported for adults. 4,8 However, despite data on the asymptomatic spread of SARS-CoV-2, this mode of transmission by children, which may spread the virus for extended periods 9 and can act as a potential source of undetected community transmission,…”

mentioning

confidence: 99%

The pediatric asymptomatic SARS-CoV-2 IgG seropositivity in the Turkish Republic of Northern Cyprus

Gazi¹,

Sarıoğlu²,

Ruh³

et al. 2022

Turk J Pediatr

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Background. While children were initially thought to have serious contributions to the coronavirus disease 2019 (COVID-19) transmission, recent studies suggest otherwise. However, the possible effect of asymptomatic pediatric spread still has not yet received enough attention. The aim of our study was to estimate asymptomatic infection rates among children in the Turkish Republic of Northern Cyprus, by using pediatric patients admitted to a university hospital without any COVID-19-associated symptoms.Methods. Blood samples collected from 80 pediatric patients with no symptoms and history of COVID-19 infection, who were admitted to a university hospital between September 2020 and January 2021, were included in the retrospective study. Isolated serum samples were tested by Dia.Pro SARS-CoV-2 IgG ELISA assays.Results. The patient group included 40 (50%) male and 40 (50%) female patients. The average age of children was 7.6 ± 4.0 years, with min-max ages ranging from 2 to 15 years. Among the 80 patients tested, only one (1.3%) was detected positive by the Dia.Pro IgG ELISA kit. Conclusions.The asymptomatic seropositivity reported in our study suggests the use of randomly performed serologic tests to monitor SARS-CoV-2 infection among the pediatric population in schools that would contribute to the public health fight against COVID-19.

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“…An important consideration for the necessity of accelerating pediatric vaccination is the potential increased transferability and higher susceptibility, which might be brought by SARS-CoV-2 variants. [59][60][61][62] A retrospective cohort study on severity of COVID-19 caused by SARS-CoV-2 variants of concern (VOC) in children demonstrated there was an increased Delta COVID-19 incidence in children and Gamma (P.1 and sublineages) rather than Alpha (B.1.1.7 and sublineages) or Delta (B.1.617.2 and sublineages) increased severity of the disease. [63] In Israel, a doubled transmission rate of SARS-CoV-2 from children aged 0 to 9 years was found during the circulation of Alpha (B.1.1.7) variant.…”

Section: Challenges For Pediatric Vaccination Due To Predominance Of ...mentioning

confidence: 99%

COVID-19 in children: epidemic issues and candidate vaccines

Zhang

Wei

Jing

et al. 2022

Chinese Medical Journal

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A large-scale vaccination of coronavirus disease-19 in adults has been conducted for nearly a year, and there is a growing recognition that immunization for children is also essential. It has been months since emergency use of pediatric COVID-19 vaccine was approved, we reviewed the prevalence and transmission of COVID-19 in children. The prevalence of COVID-19 in children is reduced due to vaccination even in a Delta prevalent period, so an increase in the vaccination rate is needed in children.Although the precise role of children in the transmission requires more research to uncover, they likely played a significant role, according to the available literature. We also described four candidate COVID-19 vaccines for children on their safety and immunogenicity and the impact of severe acute respiratory syndrome coronavirus 2 variants on childhood vaccination. Safety issues on pediatric vaccines post-approval, like adverse events following immunization and adverse events of special interest require studies on long-term and effective regulatory mechanisms.

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Implications of a highly transmissible variant of SARS-CoV-2 for children

Cited by 9 publications

References 5 publications

Viral respiratory infections and psychosis: A review of the literature and the implications of COVID-19

Viral respiratory infections and psychosis: A review of the literature and the implications of COVID-19

The pediatric asymptomatic SARS-CoV-2 IgG seropositivity in the Turkish Republic of Northern Cyprus

COVID-19 in children: epidemic issues and candidate vaccines

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