Implicaciones del óxido nítrico y otras moléculas con potencial redox en el glaucoma primario de ángulo abierto

Zanón‐Moreno, Vicente; Pons, Sara; Gallego-Pinazo, Roberto; García-Medina, J.J.; Vinuesa, I.; Bou, Vicente Vila; Pinazo-Durán, María Dolores

doi:10.4321/s0365-66912008000600006

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Regarding this research aspect, we would like to state that the aqueous humor samples were obtained, manipulated, transported, and processed by following strict protocols in order to eliminate the possibility of interferences. Formerly, we established that oxidative stress was present in the aqueous humor of the patients with POAG, and the levels were significantly higher in this group compared with the cataract patients (30). Our results are in agreement with the scientific literature regarding this topic (31)(32)(33).…”

Section: Discussionsupporting

confidence: 90%

Antioxidant Status Modifications by Topical Administration of Dorzolamide in Primary Open-Angle Glaucoma

Zanón‐Moreno

García-Medina

Gallego-Pinazo

et al. 2009

European Journal of Ophthalmology

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Section: Discussionsupporting

confidence: 90%

Antioxidant Status Modifications by Topical Administration of Dorzolamide in Primary Open-Angle Glaucoma

Zanón‐Moreno

García-Medina

Gallego-Pinazo

et al. 2009

European Journal of Ophthalmology

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“…Most of the NO in the body is in the form of nitrite and nitrate. Therefore, this method indirectly quantifies nitric oxide based on the enzymatic conversion of nitrate to nitrite by nitrate reductase, followed by a by colorimetric detection of nitrite as an azo dye product of the Griess reaction [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

Computational Analysis of Clinical and Molecular Markers and New Theranostic Possibilities in Primary Open-Angle Glaucoma

Pinazo-Durán

García-Medina

Bolarín

et al. 2020

JCM

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Primary open-angle glaucoma (POAG) is a paramount cause of irreversible visual disability worldwide. We focus on identifying clinical and molecular facts that may help elucidating the pathogenic mechanisms of the disease. By using ophthalmological approaches (biomicroscopy, ocular fundus, optical coherence tomography, and perimetry) and experimental tests (enzyme-linked immunosorbent assay (ELISA), high performance liquid chromatography (HPLC), and Western blot/immunoblotting) directed to evaluate the oxidative stress, inflammation, apoptosis, and neurodegeneration processes, we gather information to build a network of data to perform a computational bioinformatics analysis. Our results showed strong interaction of the above players and its downstream effectors in POAG pathogenesis. In conclusion, specific risk factors were identified, and molecules involved in multiple pathways were found in relation to anterior and posterior eye segment glaucoma changes, pointing to new theranostic challenges for better managing POAG progression.

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“…Products of oxidative stress are suggested as potential biomarkers. Nitric oxide (NO) is a free radical and shows higher serum [128] and aqueous humor concentration in patients with primary open angle glaucoma (POAG) [126,127]. Protein carbonyls (PC) content is the most general indicator and by far the most used marker of protein oxidation.…”

Section: Glaucomamentioning

confidence: 99%

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment

et al. 2021

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Most irreversible blindness observed with glaucoma and retina-related ocular diseases, including age-related macular degeneration and diabetic retinopathy, have their origin in the posterior segment of the eye, making their physiopathology both complex and interconnected. In addition to the age factor, these diseases share the same mechanism disorder based essentially on oxidative stress. In this context, the imbalance between the production of reactive oxygen species (ROS) mainly by mitochondria and their elimination by protective mechanisms leads to chronic inflammation. Oxidative stress and inflammation share a close pathophysiological process, appearing simultaneously and suggesting a relationship between both mechanisms. The biochemical end point of these two biological alarming systems is the release of different biomarkers that can be used in the diagnosis. Furthermore, oxidative stress, initiating in the vulnerable tissue of the posterior segment, is closely related to mitochondrial dysfunction, apoptosis, autophagy dysfunction, and inflammation, which are involved in each disease progression. In this review, we have analyzed (1) the oxidative stress and inflammatory processes in the back of the eye, (2) the importance of biomarkers, detected in systemic or ocular fluids, for the diagnosis of eye diseases based on recent studies, and (3) the treatment of posterior ocular diseases, based on long-term clinical studies.

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Implicaciones del óxido nítrico y otras moléculas con potencial redox en el glaucoma primario de ángulo abierto

Abstract: Changes in NO availability and the concomitance of oxidative stress in the aqueous humour of the POAG patients may be useful markers for identifying those at risk of glaucoma progression and visual loss.

Cited by 5 publications

References 25 publications

Antioxidant Status Modifications by Topical Administration of Dorzolamide in Primary Open-Angle Glaucoma

Antioxidant Status Modifications by Topical Administration of Dorzolamide in Primary Open-Angle Glaucoma

Computational Analysis of Clinical and Molecular Markers and New Theranostic Possibilities in Primary Open-Angle Glaucoma

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment

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