Implementation of LYSO/PSPMT Block Detector With All Digital DAQ System

Xie, Qingguo; Chen, Yuanbao; Zhu, J.; Liu, Jingjing; Wang, Xi; Liu, Wei; Chen, Xin; Niu, Muye; Wu, Zhongyi; Xi, Daoming; Wang, Luyao; Xiao, Peng; Chen, Chin-Tu; Kao, Chien-Min

doi:10.1109/tns.2013.2245771

Cited by 31 publications

(25 citation statements)

References 36 publications

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“…According to the manufacturer of PET block detector, 1.0 mm-diameter rods can be clearly resolved [28], while FWHMs along x, y, and z axis at the center of FOV of our PET sub-system are 1.139 mm, 1.750 mm, and 2.959 mm, respectively. The reconstructed Derenzo phantom image showed consistency with the results calculated from FWHM, which verified the spatial resolution of PET sub-system was between 1.2 mm and 1.6 mm.…”

Section: Discussionmentioning

confidence: 97%

“…A high-speed, low-noise CMOS X-ray detector (1512, Dexela, London, UK) was placed on the direction of 225°, opposite to the Xray tube. Four PET block detectors (Raycan Technology, Suzhou, China) [28] were fixed on four electrical linear guideways on the directions of 0°, 90°, 180°, and 270°, respectively. A back-illuminated electron-multiplying charge-coupled device (EMCCD, iXon 888, Andor, Belfast, UK) camera was chosen to collect visual/infrared photons and produce optical images for BLT, FMT, and CLT.…”

Section: Instrumentations Of the Pet/blt/fmt/clt/ct Pentamodal Imaginmentioning

confidence: 99%

See 1 more Smart Citation

In vivo pentamodal tomographic imaging for small animals

Liu¹,

Guo²,

Liu³

et al. 2017

Biomed. Opt. Express

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Multimodality molecular imaging emerges as a powerful strategy for correlating multimodal information. We developed a pentamodal imaging system which can perform positron emission tomography, bioluminescence tomography, fluorescence molecular tomography, Cerenkov luminescence tomography and X-ray computed tomography successively. Performance of sub-systems corresponding to different modalities were characterized. In vivo multimodal imaging of an orthotopic hepatocellular carcinoma xenograft mouse model was performed, and acquired multimodal images were fused. The feasibility of pentamodal tomographic imaging system was successfully validated with the imaging application on the mouse model. The ability of integrating anatomical, metabolic, and pharmacokinetic information promises applications of multimodality molecular imaging in precise medicine. Som, C. N. Wan, A. P. Wolf, D. E. Kuhl, and M. Reivich, "Radiopharmaceuticals XXVII. 18F-labeled 2-deoxy-2-fluoro-d-glucose as a radiopharmaceutical for measuring regional myocardial glucose metabolism in vivo: tissue distribution and imaging studies in animals," J. Nucl. Med. 18(10), 990-996 (1977).

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Section: Discussionmentioning

confidence: 97%

Section: Instrumentations Of the Pet/blt/fmt/clt/ct Pentamodal Imaginmentioning

confidence: 99%

In vivo pentamodal tomographic imaging for small animals

Liu¹,

Guo²,

Liu³

et al. 2017

Biomed. Opt. Express

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“…TDC and the proposed energy calibration method are realized in a field programmable gate array(FPGA). The digital samples are sent to personal computer(PC) via Ethernet, and the scintillation pulse is reconstructed with a model formulated as a straight line followed by an exponential decay [2]. To reduce the error of pulse fitting, only the scintillation pulse with its amplitude larger than 3 voltage thresholds are used for reconstruction.…”

Section: Methodsmentioning

confidence: 99%

“…Digitizing scintillation pulses with the Multi-voltage threshold(MVT) method shows great potentials for building all-digital positron emission tomography (PET) [2]. An accurate pulse model used Manuscript for pulse fitting is a critical factor to precisely reconstruct the pulse in the MVT method.…”

Section: Introductionmentioning

confidence: 99%

Energy calibration method for an all-digital high resolution gamma-ray spectroscopy

Long

Zhang

Xiong

et al. 2014

2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

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Digitizing scintillation pulses with the Multi-voltage threshold (MVT) method shows great potentials for building alldigital positron emission tomography (PET). In this paper, we introduce the MVT method into gamma-ray spectroscopy. An accurate scintillation pulse model used in pulse fitting is especially important to get precise energy when implementing the MVT in gamma-ray spectroscopy, since a wide-range energy needs to be measured with limited MVT samples. However, accurately model the scintillation pulse is a not trivial work, as the physical model of scintillation pulse is not only determined by scintillator and photo-electric device but also the parasitic capacitance and inductance of the read out circuits. The unideal scintillation pulse model adopted in the MVT degrades the spectral accuracy and the energy resolution. To address this problem, an energy calibration method is proposed in this paper. By measuring the energy of scintillation pulses with different pulse amplitudes with high sample rate ADC and the MVT respectively, a look-up table is generated by dividing the energy obtained in the ADC to that in the MVT. The look-up table is used as calibration coefficient to correct the energy in the all-digital data acquisition system (DAQ) based on the MVT. Our preliminary results show that with the proposed energy calibration method, the peak-to-valley ratio in the Cs-137 energy spectrum is increased by about 1.5 times and the energy resolution is improved from 6.1% to 3.8% at 662 keV with LaBr3/PMT detector, which is equivalent to that of a 5 GSPS ADC.

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“…A 14 × 14 tapered light-guide was designed to deliver the photons from 18 × 18 LYSO crystals into the PSPMT [9,10]. The top entrance size of the light-guide remains the same with the scintillator array crystal area (23.5 × 23.5 mm 2 ).…”

Section: Modular Construction Of the Pet Detectormentioning

confidence: 99%

Positron emission tomography detector performance with different crystal pitches

Tong

Fan

Dong

et al. 2017

Radiat Detect Technol Methods

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Aims: In this work, we evaluated the performance of three pitches positron emission tomography (PET) detectors for building a high-resolution small-animal PET imaging experimental platform. Methods: The evaluation of PET detectors includes twodimensional crystal identification, energy resolution, and crystal look-up table. The nuclear instrumentation module and PXI data acquisition (DAQ) system were both used to obtain flood images. The energy spectrum of the Na-22 source was measured. PET detectors of 2.0 and 1.6 mm pitches used in our present experiment were composed of lutetium yttrium oxyorthosilicate (LYSO) crystals directly coupled to position-sensitive photomultiplier tubes (PSPMTs). The 1.3-mm pitch detector comprises a LYSO crystal, a tapered light-guide, and a PSPMT. The crystal sizes of the detectors were a 10 × 10 array of 2.0 × 2.0 × 10 mm 3 crystals, a 10 × 10 array of 1.6 × 1.6 × 10 mm 3 crystals, and an 18×18 array of 1.3×1.3×10 mm 3 crystals, respectively. Due to the lower sampling frequency of the DAQ system, a spline interpolation algorithm was introduced in the signal waveform to reconstruct the peak values. Results: The experimental results indicated that all three PET detector crystals could be clearly identified. A detailed analysis demonstrated that the key characteristic full width at half maximum (FWHM) values of the crystals profile could reach 0.46 ± 0.03, 0.32 ± 0.03, and 0.21 ± 0.02 mm, while the crystal average energy resolutions were 16.8% ± 1.76%, 20.1% ± 2.24%, and 31.5% ± 3.76%, which correspond to B YongZhi Yin yinyzh@lzu.edu.cn 1 School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000, China pitches of 2.0-, 1.6-, and 1.3-mm, respectively. Conclusions: The PET detector modules of LYSO crystal arrays could be potentially used in the small-animal PET imaging applications and are promising to achieve submillimeter PET images.

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Implementation of LYSO/PSPMT Block Detector With All Digital DAQ System

Cited by 31 publications

References 36 publications

In vivo pentamodal tomographic imaging for small animals

In vivo pentamodal tomographic imaging for small animals

Energy calibration method for an all-digital high resolution gamma-ray spectroscopy

Positron emission tomography detector performance with different crystal pitches

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