Background and Purpose-An effective stroke code system that can expedite rapid thrombolytic treatment requires effective notification/communication and an organized team approach. We developed a stroke code program based on the computerized physician order entry (CPOE) system and investigated whether implementation of this CPOE-based program is useful for reducing the time from arrival at emergency departments (ED) to evaluation steps and the initiation of thrombolytic treatment in various hospital settings. Methods-The CPOE-based program was implemented by 10 hospitals. Time intervals from arrival at the ED to blood tests, computed tomography scanning, and thrombolytic treatment during the 1-year period before and the 1-year period after the program implementation were compared. Results-Time intervals from ED arrival to evaluation steps were significantly reduced after implementation of the CPOE-based program. Times from ED arrival to CT scan, complete blood counts, and prothrombin time testing were reduced by 7.7 minutes, 5.6 minutes, and 26.8 minutes, respectively (PϽ0.001). The time from ED arrival to intravenous thrombolysis was reduced from 71.7Ϯ33.6 minutes to 56.6Ϯ26.9 minutes (PϽ0.001). The number of patients who were treated with thrombolysis increased from 3.4% (199/5798 patients) before the CPOE-based program to 5.8% (312/5405 patients) afterward (PϽ0.001). The CPOE implementation also improved the inverse relationship between onset-to-door time and door-to-needle time. Key Words: acute stroke Ⅲ computerized physician order entry Ⅲ stroke Ⅲ thrombolysis T he efficacy of intravenous (IV) tissue plasminogen activator in acute ischemic stroke is time-dependent. 1,2 However, a recent systemic review indicated that the average time from a patient's arrival at the emergency department (ED) to the initiation of thrombolytic treatment exceeded 60 minutes in most studies. 3 There have been several efforts to reduce in-hospital time delays, including reorganization of the ED, 4 use of point-of-care international normalized ratio testing, 5 and use of an acute stroke triage pathway. 6 Stroke code systems and stroke team activities based on care protocols may expedite rapid thrombolytic treatment. 4 However, operation of a stroke code system requires many resources, effective communication between staff members of various departments, and adequate monitoring with feedback to continually improve the system. One promising approach for an effective stroke code system is using computerized physician order entry (CPOE). CPOE is a process that physicians use to enter medical orders electronically. These medical orders are communicated over a computer network linked to a hospital information system with physicians, nurses, technicians, and other staff in various departments. 7 accurate and rapid medical order entry and enables relevant staff to access necessary information immediately. Because CPOE permits capture of time data for individual steps more easily and objectively, it is useful to monitor the program's e...