Implantation of human amniotic epithelial cells prevents the degeneration of nigral dopamine neurons in rats with 6-hydroxydopamine lesions

Kakishita, Koji; Nakao, Naoyuki; Sakuragawa, Norio; Itakura, Toru

doi:10.1016/s0006-8993(03)02875-0

Cited by 110 publications

(80 citation statements)

References 25 publications

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“…Very similar findings have also been reported for AECs that confer neuroprotection and functional recovery in animal models of Parkinson's disease (Bankiewicz et al 1994;Kakishita et al 2000Kakishita et al , 2003Kong et al 2008) and ischaemia (Liu et al 2008). The observed therapeutic effects are probably mediated by secretion of diffusible factors, including neurotransmitters (Elwan & Sakuragawa 1997;Sakuragawa et al 1997Sakuragawa et al , 2001) and neurotrophic and growth factors (Koizumi et al 2000;Uchida et al 2000).…”

Section: Brainsupporting

confidence: 77%

Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues

Abdulrazzak

Moschidou

Jones

et al. 2010

J. R. Soc. Interface.

127

118

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Foetal stem cells (FSCs) can be isolated during gestation from many different tissues such as blood, liver and bone marrow as well as from a variety of extraembryonic tissues such as amniotic fluid and placenta. Strong evidence suggests that these cells differ on many biological aspects such as growth kinetics, morphology, immunophenotype, differentiation potential and engraftment capacity in vivo. Despite these differences, FSCs appear to be more primitive and have greater multi-potentiality than their adult counterparts. For example, foetal blood haemopoietic stem cells proliferate more rapidly than those found in cord blood or adult bone marrow. These features have led to FSCs being investigated for pre-and post-natal cell therapy and regenerative medicine applications. The cells have been used in pre-clinical studies to treat a wide range of diseases such as skeletal dysplasia, diaphragmatic hernia and respiratory failure, white matter damage, renal pathologies as well as cancers. Their intermediate state between adult and embryonic stem cells also makes them an ideal candidate for reprogramming to the pluripotent status.

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Section: Brainsupporting

confidence: 77%

Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues

Abdulrazzak

Moschidou

Jones

et al. 2010

J. R. Soc. Interface.

127

118

View full text Add to dashboard Cite

show abstract

“…After transplantation into rat models of Parkinson's disease, hAEC have been shown to produce dopamine and prevent neuron degeneration (Kakishita et al 2000(Kakishita et al , 2003. The neuroprotective effect of hAEC in an animal model of Parkinson's disease is further supported by the recent study of Kong et al (2008), who show that hAEC display neuroprotective and neurogenic effects when transplanted into the striatum of Parkinson's disease mice, and result in behavioural improvement in transplanted mice with respect to controls.…”

Section: Human Amniotic Epithelial Cellsmentioning

confidence: 96%

Placenta-derived stem cells: new hope for cell therapy?

2008

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An urgent current need in regenerative medicine is that of identifying a plentiful, safe and ethically acceptable stem cell source for the development of therapeutic strategies to restore functionality in damaged or diseased organs and tissues. In this context, human term placenta represents a prime candidate, as it is available in nearly unlimited supply, is ethically problem-free and easily procured. Placental cells display differentiation capacity toward all three germ layers, while also displaying immunomodulatory effects, therefore supporting the possibility that they could be applied in an allogeneic transplantation setting. Although promising data have been reported to date, further study is required to fully characterize the differentiation potential of placenta-derived cells and to identify their possible clinical applications. Here, we provide a snapshot of current knowledge regarding the potential of cells from the amniotic membrane of human term placenta to address current shortcomings in the field of regenerative medicine.

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“…The serum prevents expression of neural markers in AECs Since it has been shown that the serum prevents neural differentiation (Kawasaki et al, 2000), the serum was decreased in the medium. At first, the serum was completely omitted from the medium.…”

Section: H Niknejad Et Al Neuronal Differentiation Of Amniotic Epitmentioning

confidence: 99%

Differentiation factors that influence neuronal markers expression in vitro from human amniotic epithelial cells

Niknejad

Peirovi²,

Ahmadiani³

et al. 2010

eCM

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The differentiation of neural cells from embryonic stem cells is influenced by several growth factors. Amniotic epithelial cells (AECs) share many of the same characteristics as embryonic stem cells, and therefore those factors may similarly affect the derivation of neural cells from AECs. In this study, we examined the differentiation of neural cells in vitro from AECs following AECs treatment with retinoic acid (RA), basic fibroblast growth factor (bFGF) as well as investigation of bFGF withdrawal on neuronal differentiation. We also studied whether blocking bone morphogenetic protein (BMP) signaling using its antagonist, noggin, affects the derivation of neuronal cells from AECs. The effects of serum on the rate of neural markers expression were also examined. Analysis of AECs derived neurons was performed at some neural markers expression level by immunocytochemistry. All cultures treated with noggin showed the higher levels of neural markers expression than noggin free cultures. Combined treatment with bFGF and RA showed the highest level of neural markers in all treatment groups with or without noggin. bFGF withdrawal did not promote expression of neural markers, while its maintenance increased the expression of these markers. Serum-free condition decreased the viability of cells but increased the rate of neural markers expression. These results show the capability of AECs to express neural cell markers and this ability is affected by some factors including serum, noggin, bFGF and RA.

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Implantation of human amniotic epithelial cells prevents the degeneration of nigral dopamine neurons in rats with 6-hydroxydopamine lesions

Cited by 110 publications

References 25 publications

Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues

Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues

Placenta-derived stem cells: new hope for cell therapy?

Differentiation factors that influence neuronal markers expression in vitro from human amniotic epithelial cells

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