Placenta-derived stem cells: new hope for cell therapy?

Evangelista, Marco; Soncini, M.; Parolini, Ornella

doi:10.1007/s10616-008-9162-z

Cited by 98 publications

(87 citation statements)

References 55 publications

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“…The recent isolation of cells with stem cell features from human amnion and amniotic fluid, opens many new venues (reviewed in Evangelista et al, 2008;Fauza, 2004;Ilancheran et al, 2009;Marcus and Woodbury, 2008;Miki and Strom, 2006;Pappa and Anagnou, 2009;Parolini et al, 2008;Parolini et al, 2009;Prusa and Hengstschlager, 2002;Siegel et al, 2008;Toda et al, 2007;Insausti et al, 2010). The low immunogenicity and the immunomodulatory properties (Akle et al, 1981;Banas et al, 2008;Ilancheran et al, 2007;Kubo et al, 2001;Wolbank et al, 2009) make amniotic membrane-derived epithelial stem cells promising for regeneration of tissues and ultimately even organs.…”

Section: Amnion-derived Stem Cellsmentioning

confidence: 99%

On the origin of amniotic stem cells: of mice and men

Dobreva¹,

Pereira²,

Deprest³

et al. 2010

Int. J. Dev. Biol.

132

137

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A common characteristic of mammals is the development of extraembryonic supporting tissues and organs that are required for embryonic implantation, survival and development in utero. The amnion is the innermost extraembryonic membrane that eventually surrounds the fetus of amniotes, and contains the amniotic fluid. Next to its function in in utero development, the amnion has been shown to have an important potential for clinical applications. It is mainly used as a dressing to stimulate healing in skin and ocular wounds. Moreover, cells derived from the amniotic membrane and amniotic fluid have been reported to possess stem cell features, like pluripotent differentiation ability. Little is known about the early development of this membrane in humans. The mouse is a powerful genetic model organism that can be used to address the dynamics and the developmental origin of amnion and amnion-derived stem cells. Here, we discuss some fundamental differences in amnion development in the disc-shaped primate embryo and in the cup-shaped mouse embryo. We emphasize the consequences that this may have on the derivation of amniotic "stem" cells. After revision of the different isolation procedures of amniotic (fluid) derived "stem" cells from rodents, we reveal striking differences in the sources used to derive these cells across studies. The profound differences in the development of the extraembryonic membranes and cavities between primates and rodents may result in comparing cell types of different developmental origins, eventually leading to missinterpretations.

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Section: Amnion-derived Stem Cellsmentioning

confidence: 99%

On the origin of amniotic stem cells: of mice and men

Dobreva¹,

Pereira²,

Deprest³

et al. 2010

Int. J. Dev. Biol.

132

137

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“…Transplantation of hFMSCs after stroke in rodents has shown to reduce injury progression by modulating the inflammatory response and facilitating functional recovery (16,19). Furthermore, other in vivo experiments have demonstrated long-term survival of hFMSCs after xenogeneic transplantation into immune-competent animals (12,14).…”

Section: Introductionmentioning

confidence: 99%

Distinct In Vitro Properties of Embryonic and Extraembryonic Fibroblast-Like Cells are Reflected in their in Vivo Behavior following Grafting in the Adult Mouse Brain

et al. 2015

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Although intracerebral transplantation of various fibroblast(-like) cell populations has been shown feasible, little is known about the actual in vivo remodeling of these cellular grafts and their environment. In this study, we aimed to compare the in vitro and in vivo behavior of two phenotypically similar-but developmentally distinctfibroblast-like cell populations, namely, mouse embryonic fibroblasts (mEFs) and mouse fetal membrane-derived stromal cells (mFMSCs). While both mEFs and mFMSCs are readily able to reduce TNF-a secretion by LPS/IFN-gactivated BV-2 microglia, mFMSCs and mEFs display strikingly opposite behavior with regard to VEGF production under normal and inflammatory conditions. Whereas mFMSCs downregulate VEGF production upon coculture with LPS/IFN-g-activated BV-2 microglia, mEFs upregulate VEGF production in the presence of LPS/ IFN-g-activated BV-2 microglia. Subsequently, in vivo grafting of mFMSCs and mEFs revealed no difference in microglial and astroglial responses toward the cellular grafts. However, mFMSC grafts displayed a lower degree of neoangiogenesis compared to mEF grafts, thereby potentially explaining the lower cell number able to survive in mFMSC grafts. In summary, our results suggest that physiological differences between fibroblast-like cell populations might lie at the basis of variations in histopathological and/or clinical outcome following cell grafting in mouse brain.

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“…The autologous trans plantation of these cells allows to avoid immune reaction problems encountered with embryonic stem cell lines [7] and the increasing number of potential sources, from the bone marrow to the adipose tissue to the teeth pulp [8][9][10][11][12][13][14][15][16], that are being identified, partly compensate for the low number of cells that can be collected and foster the diffusion of these cells in regenerative medicine.…”

Section: Introductionmentioning

confidence: 99%