Implantation of an inactive epiretinal poly(dimethyl siloxane) electrode array in dogs

Güven, Dilek; Weiland, James D.; Maghribi, Mariam N; Davidson, Jordan; Mahadevappa, Manjunatha; Roizenblatt, Roberto; Qiu, Guo-Hua; Krulevitz, Peter; Wang, Xiaopeng; LaBree, Laurie; Humayun, Mark S.

doi:10.1016/j.exer.2005.05.008

Cited by 40 publications

(28 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…New techniques are also being developed that could bridge the gap between IC-based devices and soft-polymer devices. Adding circuitry into soft polymers is an active area of research (84). Incorporation of magnetic particles into mPADs posts has been demonstrated (85).…”

Section: Resultsmentioning

confidence: 99%

Microsystems for Biomechanical Measurements

et al. 2008

View full text Add to dashboard Cite

ABSTRACT:The use of microtechnology to make biomechanical measurements allows for the study of cellular and subcellular scale mechanical forces. Forces generated by cells are in the few nanoNewton to several microNewton range and can change spatially over subcellular size scales. Transducing forces at such small size and force scales is a challenging task. Methods of microfabrication developed in the integrated circuit industry have allowed researchers to build platforms with cellular and subcellular scale parts with which individual cells can interact. These parts act as transducers of stresses and forces generated by the cell during migration or in the maintenance of physical equilibrium. Due to the size and sensitivity of such devices, quantitative studies of single cell and even single molecule biomechanics have become possible. In this review we focus on two classes of cellular force transducers: silicon-based devices and softpolymer platforms. We concentrate on the biomechanical discoveries made with these devices and less so on the engineering behind their development because this is covered in great detail elsewhere.

show abstract

Section: Resultsmentioning

confidence: 99%

Microsystems for Biomechanical Measurements

et al. 2008

View full text Add to dashboard Cite

show abstract

“…The species involved include rats (n=6) [26,29,76,80,81,96], rabbits (n=14) [33,36,42,72,73,90,94,95,102,103,105,106,116,121], cats (n=18) [18, 19, 21-23, 30, 32, 43, 78, 79, 82, 93, 98, 99, 101, 114, 117, 120], dogs (n=4) [16,39,40,66], sheep (n=1) [51] and pigs/minipigs (n=9) [34,42,49,59,69,91,92,100,102]. Two papers [16,26] which involved three animal species do not figure in Table 2 due to lack of space, but are discussed in the review.…”

Section: Resultsmentioning

confidence: 99%

“…Dogs are expensive to house, in particular because the retinal degeneration takes several months to develop (in RCD1 dogs, the ERG extinguishes at approximately 18 weeks) [66]. We found three canine studies in which implantbiocompatibility and biostability [39,40,66] and one study in which electrically elicited responses (EERs) produced by epiretinal stimulation [16] were examined.…”

Section: Catmentioning

confidence: 99%

See 1 more Smart Citation

A review of in vivo animal studies in retinal prosthesis research

Bertschinger¹,

Beknazar²,

Silva

et al. 2008

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Background The development of a functional retinal prosthesis for acquired blindness is a great challenge. Rapid progress in the field over the last 15 years would not have been possible without extensive animal experimentation pertaining to device design and fabrication, biocompatibility, stimulation parameters and functional responses. This paper presents an overview of in vivo animal research related to retinal prosthetics, and aims to summarize the relevant studies. Methods A Pubmed search of the English language literature was performed. The key search terms were: retinal implant, retinal prosthesis, artificial vision, rat, rabbit, cat, dog, sheep, pig, minipig. In addition a manual search was performed based on references quoted in the articles retrieved through Pubmed. Results We identified 50 articles relevant to in vivo animal experimentation directly related to the development of a retinal implant. The highest number of publications related to the cat (n=18). Conclusion The contribution of animal models to the development of retinal prosthetic devices has been enormous, and has led to human feasibility studies. Grey areas remain regarding long-term tissue-implant interactions, biomaterials, prosthesis design and neural adaptation. Animals will continue to play a key role in this rapidly evolving field.

show abstract

“…18 Because of a lack of data from the initial clinical trial, we matched measurements obtained from our patients with normative values from RP patients obtained by Huang et al 19 During acute trials with epiretinal electrode arrays in dogs, an increase in retinal thickness under the arrays in the first month after implantation has been recorded. 18 In our human volunteers, there is remarkable variation in central retinal thickness. However, no significant oedema can be observed 24 months post implantation.…”

Section: Discussionmentioning

confidence: 99%