Implantation and explantation of an active epiretinal visual prosthesis: 2-year follow-up data from the EPIRET3 prospective clinical trial

Menzel‐Severing, Johannes; Laube, Thomas; Brockmann, Claudia; Bornfeld, Norbert; Mokwa, W.; Mazinani, Babac; Walter, Peter; Roessler, Gernot

doi:10.1038/eye.2012.35

Cited by 69 publications

(45 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are various types of visual prostheses, and according to the locations that are stimulated, they can be generally divided into the following categories: epiretinal, 1,3,[19][20][21][22] subretinal, 2,8,13,[23][24][25] suprachoroidal, 4,15,26,27 intrapapillary, 28 extraocular, 12 thalamic, 7 cortical, 6,10,11 and optic nerve (ON). 5,14 Among them, the ON approach may potentially achieve artificial vision over a relatively large area of the visual field.…”

Section: Resultsmentioning

confidence: 99%

Electrically Evoked Responses in the Rabbit Cortex Induced by Current Steering With Penetrating Optic Nerve Electrodes

Yan

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. Current steering is a neural stimulation strategy that uses simultaneous stimulation of adjacent electrodes to produce additional intermediate stimulation sites and thus improves spatial resolution. We investigated the feasibility of current steering using electrophysiological and computational methods after implanting paired penetrating electrodes into the rabbit's optic nerve (ON). METHODS.Penetrating electrodes at different interelectrode distances were implanted into the ON and electrically evoked cortical potentials (EEPs) in V1 recorded with a 6 3 8 array. The current thresholds, EEP amplitudes, and spatial distributions were analyzed during current steering. Computational simulation studies were performed based on finite element models to calculate the area and spatial distribution of recruited ON fibers using a current steering stimulation strategy. RESULTS.Threshold reduction and EEP amplitude enhancement were found with simultaneous stimulation of closely spaced electrode pairs. Spatially shifted cortical responses were achieved using current steering, whereas the amplitudes and spatial spreads of the responses were similar to that elicited by a single electrode. Computational simulations suggested that the centroid of the ON recruitment area could be modulated by current steering while the total recruitment area did not show any appreciable variability at a fixed current intensity.CONCLUSIONS. Current steering is a useful strategy to enhance the spatial resolution of an ON prosthesis without increasing the number of physical electrodes. This study provides useful information for optimizing the design of stimulation strategies with a penetrating ON prosthesis.

show abstract

Section: Resultsmentioning

confidence: 99%

Electrically Evoked Responses in the Rabbit Cortex Induced by Current Steering With Penetrating Optic Nerve Electrodes

Yan

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…To date, human clinical trials with only two types of epiretinal implants have been published [33,35,36,37]. Both systems can elicit phosphenes, but functional vision has been reported only for the Argus I and Argus II prostheses (Second Sight Medical Products) [33,37].…”

Section: Electronic Retinal Implantsmentioning

confidence: 99%

“…The safety of epiretinal implants has been published from two human application trials with follow-ups of 4 weeks to over 2 years [33,35,36,38] and an animal study observation with implantation time of 3-8 weeks [34]. Clinically, there were some retinal detachments needing surgical interventions, isolated cystoid macular edema or epiretinal membranes, as well as proliferations around the retinal tacks [33,35,36,38].…”

Section: Electronic Retinal Implantsmentioning

confidence: 99%

“…This enables an optimization of the functional artificial vision despite a relatively low number of pixels in the electrode array (ranging from 16 to 60 [33,35,36,37]). The external camera also eliminates natural eye movements from the vision process, which may result in perception fading due to missing microsaccades refreshing the retinal image.…”

Section: Electronic Retinal Implantsmentioning

confidence: 99%

“…Bypassing the bipolar cells requires transformation electronics for signal generation for direct ganglion cell stimulation. All epiretinal visual implants are provided with an external battery system for power supply [33,34,35,36]. …”

Section: Electronic Retinal Implantsmentioning

confidence: 99%

See 2 more Smart Citations

Electronic Approaches to Restitute Vision in Patients with Neurodegenerative Diseases of the Retina

Štingl¹,

Zrenner²

2013

Ophthalmic Res

View full text Add to dashboard Cite

Degenerations of the outer retina are hereditary diseases leading to significant loss of vision. Several concepts of active electrical stimulation of the remaining retinal network resulted in the development of retinal visual implants and prosthetic vision. Subretinal and epiretinal visual implants are currently the leading approaches in restoring functional vision in blind humans with retinitis pigmentosa or other outer retinal degenerations. This review gives a short overview about the principles, advantages, limitations and vision outcome of the up-to-date published artificial vision by electronic visual implants, as well as their known biocompatibility and safety issues.

show abstract

Assessment of Postoperative Morphologic Retinal Changes by Optical Coherence Tomography in Recipients of an Electronic Retinal Prosthesis Implant

et al. 2019

View full text Add to dashboard Cite

IMPORTANCEThe postoperative retinal changes at the interface between an implant electrode array and the retina and whether these anatomic changes have an association with the patient visual performance are unknown.OBJECTIVE To report morphologic changes in recipients of an Argus II Retinal Prosthesis.DESIGN, SETTING, AND PARTICIPANTS This consecutive, noncomparative case series study included a retrospective review of the preoperative and postoperative optical coherence tomography of 33 eyes among 33 individuals who underwent Argus II Retinal Prosthesis System implantation between October 28, 2011, and June 8, 2017, at 2 different centers, by the same surgeon (S.R.

show abstract

Implantation and explantation of an active epiretinal visual prosthesis: 2-year follow-up data from the EPIRET3 prospective clinical trial

Cited by 69 publications

References 18 publications

Electrically Evoked Responses in the Rabbit Cortex Induced by Current Steering With Penetrating Optic Nerve Electrodes

Electrically Evoked Responses in the Rabbit Cortex Induced by Current Steering With Penetrating Optic Nerve Electrodes

Electronic Approaches to Restitute Vision in Patients with Neurodegenerative Diseases of the Retina

Assessment of Postoperative Morphologic Retinal Changes by Optical Coherence Tomography in Recipients of an Electronic Retinal Prosthesis Implant

Contact Info

Product

Resources

About