Implantation of alloplastic material increases survival of mice subsequently exposed to polymicrobial sepsis

Keßler, Wolfram; Ebker, Tobias; Koerner, Pia; Poetschke, Christian; Cziupka, Katharina; Traeger, Tobias; Westerholt, Alexandra; Mehmcke, Hendrik; Neher, Friederike; Jack, Robert Smail; Heidecke, Claus–Dieter; Maier, Stefan A.

doi:10.1007/s00423-009-0463-2

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“…Furthermore, there are studies that describe a slight immunostimulatory effect of very limited surgical procedures [22]. Following minor surgery, the survival rate in a murine polymicrobial sepsis model (CASP) was increased compared to that in a group without previous surgical trauma [23]. Consequently, it is important to reduce the degree of surgical trauma as the most crucial factor in postoperative immunosuppression and therefore in tumour progression in general.…”

Section: Discussionmentioning

confidence: 99%

Surgical Trauma Leads to a Shorter Survival in a Murine Orthotopic Pancreatic Cancer Model

Menges

Klöcker²,

Diedrich³

et al. 2014

Eur Surg Res

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Background: Abdominal surgery is frequently followed by immune dysfunction usually lasting for several days. This is especially important in cases with tumour diseases as an intact immune function is essential in this situation. Therefore, we analysed the outcome of tumour-bearing mice in a mouse model of surgically induced immune dysfunction (SID). Methods: In male C57BL/6 mice, a pancreatic tumour was implanted orthotopically. Following tumour implantation, the model of SID was applied. The control groups were either laparotomised or underwent no surgical procedure. The survival rate was determined by observation for >60 days. The tumour growth progress was imaged by a 7-tesla small animal MRI. Results: On day 60 after tumour implantation, the survival rate in SID mice was reduced to 41%. In the laparotomised group, 81% of mice survived, while the control group had a survival rate of 75%. These differences were significant (SID vs. control: p < 0.02, and SID vs. laparotomy: p < 0.002). The tumour volume was not influenced by the degree of surgical trauma. Conclusion: In pancreatic cancer, the SID model is ideally suited to investigate the influence of SID on this tumour entity.

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Section: Discussionmentioning

confidence: 99%

Surgical Trauma Leads to a Shorter Survival in a Murine Orthotopic Pancreatic Cancer Model

Menges

Klöcker²,

Diedrich³

et al. 2014

Eur Surg Res

Self Cite

View full text Add to dashboard Cite

show abstract

Implantation of alloplastic material increases survival of mice subsequently exposed to polymicrobial sepsis

Abstract: The early implantation of alloplastic material modulates the immune system and leads to an increased survival of a polymicrobial sepsis. Identifying the molecular nature of this effect might point the way to a new therapeutic approach to reduce sepsis mortality.

Cited by 1 publication

References 20 publications

Surgical Trauma Leads to a Shorter Survival in a Murine Orthotopic Pancreatic Cancer Model

Surgical Trauma Leads to a Shorter Survival in a Murine Orthotopic Pancreatic Cancer Model

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