Implant Migration in Cervical Disk Arthroplasty

Özbek, Zühtü; Özkara, Emre; Arslantaş, Ali

doi:10.1016/j.wneu.2016.10.023

Cited by 17 publications

(8 citation statements)

References 17 publications

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“…Most researches reported favorable clinical outcomes and confirmed the success of its core idea — protecting the adjacent segment. However, complications related to instability including subsidence, migration and dislocation are still commonly seen clinically, with an reported occurrence rate of 3–10%, 8.2–10.9% and 0.5–3.06% [ 17 – 20 ], respectively. Such complications inhibit the recovery of symptoms after surgery and may lead to an ending of re-operation.…”

Section: Discussionmentioning

confidence: 99%

Parathyroid hormone enhances gap healing and osseointegration in orthopedic porous coated titanium implants: a correlative micro-computed tomographic, histomorphometric and biomechanical analysis

Gao

Meng

Hao

et al. 2022

BMC Musculoskelet Disord

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Background Parathyroid hormone, with its anabolic effect on bone formation, has shown excellent outcomes of curing postmenopausal osteoporosis as well as enhancing osseointegration around orthopaedic and stomatologic implants.The purpose of the present study is to test if low-dose intermittent PTH (1–34) treatment could achieve a satisfactory osseointegration in 2-mm peri-implant gaps, as to provide a new idea for improving the stability of such prosthesis, which will be of great clinical value. Methods A custom-made titanium implant was implanted on the calvarium of New Zealand White rabbits. 48 male rabbits were randomly divided into control and PTH group. PTH group received subcutaneous injection of PTH (20 μg/day, 5 days/week). Animals were sacrificed at 4 and 8 weeks after surgery. Quantitative micro-computed tomography, histology and biomechanical pull-out testing were performed to evaluate the gap healing at implantation site. Results Analysis of micro-computed tomography demonstrated that PTH group achieved more new bone formation in 2-mm gaps and on bone-implant interface. Quantitatively, significant differences were observed between two groups in regard to BIC and BV/TV at each time-point. Histological staining revealed that PTH group had a superiority in trabecular number, thickness, separation and better osseointegration compared to control group. As for biomechanical pull-out testing, PTH group also showed significant improvement of ultimate force than control group. Conclusions Low-dose intermittent administration of PTH for 4 and 8 weeks enhances early osseointegration and fixation of orthopedic implants surrounded by a 2-mm gap in terms of increased bone regeneration and mechanical stability. These findings suggest PTH a potential for reducing the postoperative complications of implants by improving bone healing at peri-implant gaps.

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Section: Discussionmentioning

confidence: 99%

Parathyroid hormone enhances gap healing and osseointegration in orthopedic porous coated titanium implants: a correlative micro-computed tomographic, histomorphometric and biomechanical analysis

Gao

Meng

Hao

et al. 2022

BMC Musculoskelet Disord

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“…The largest report of symptomatic migrations comprised 5 patients who underwent single or multiple-level CDA in a single institution, with an overall rate of 0.4% of all cervical arthroplasties performed. 40 In four cases, the device was explanted and revised with ACDF and in one patient, the implant was simply removed. Zhai reported a case of migration in a two-level arthroplasty that presented with dysphagia and was revised with a corpectomy of the middle vertebra and multilevel fusion.…”

Section: Discussionmentioning

confidence: 99%

Multiple Contiguous-Level Cervical Disc Arthroplasties: Unique Considerations

Lopez

Gopez

2019

JHN Journal

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This Article is brought to you for free and open access by the Jefferson Digital Commons. The Jefferson Digital Commons is a service of Thomas Jefferson University's Center for Teaching and Learning (CTL). The Commons is a showcase for Jefferson books and journals, peer-reviewed scholarly publications, unique historical collections from the University archives, and teaching tools. The Jefferson Digital Commons allows researchers and interested readers anywhere in the world to learn about and keep up to date with Jefferson scholarship. This article has been accepted for inclusion in JHN Journal by an authorized administrator of the Jefferson Digital Commons.

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“…We found an NDI success rate of 83.6%, which was also comparable to the NDI success rate of 86.1% [ 5 ] and 87.0% [ 6 ] in the two FDA studies. The reported incidence of prosthesis dislocation after CDA varied from 3.1 to 19.6% [ 9 , 16 , 17 ]. No serious adverse events including prosthesis dislocation or failure were occurred in the present study.…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiographic outcomes of cervical disc arthroplasty with Prestige-LP Disc: a minimum 6-year follow-up study

Zeng

Líu

Xiao

et al. 2018

BMC Musculoskelet Disord

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BackgroundCervical disc arthroplasty (CDA) has been considered as an alternative to cervical arthrodesis in the treatment of cervical degenerative disc diseases (CDDD). The aim of this study was to assess the long-term clinical and radiographic outcomes of CDA with Prestige-LP Disc.MethodsA total of 61 patients who underwent single- or two-level CDA with Prestige-LP Disc were retrospectively investigated at a minimum of 6-year follow-up. Clinical assessments included visual analogue scale (VAS) for neck and arm pain, Neck Disability Index (NDI), and Japanese Orthopedic Association (JOA) score. Radiological evaluations included range of motion (ROM) of the index and adjacent levels, segmental angle, cervical sagittal alignment, heterotopic ossification (HO) and adjacent segment degeneration (ASD).ResultsSignificant and maintained improvement in VAS for neck and arm, NDI and JOA were observed after a mean follow-up of 82.3 months (p < 0.001). The preoperative ROM of the index level was 9.7°, which was maintained at 2-and 4-year follow-up (9.3°, p = 0.597; 9.0°, p = 0.297), but was decreased to 8.0° at final follow-up (p = 0.019). Mobility was maintained in 80.5% (62/77) of the implanted prostheses at final follow-up. ROM of the superior and inferior adjacent segments, cervical sagittal alignment and cervical angel were all maintained. The incidence of HO was 42.9% at final follow-up, but it did not influence the clinical outcome. Radiographic ASD were detected in 29.5% of the patients. However, the incidence of symptomatic ASD was only 6.6%.ConclusionCervical disc arthroplasty with Prestige-LP Disc demonstrated a maintained and satisfactory clinical outcome at a minimal of 6-year follow-up, with majority of the prostheses remained mobile. Cervical disc arthroplasty with Prestige-LP Dis can be considered as an effective surgical method in treating CDDD.

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Implant Migration in Cervical Disk Arthroplasty

Cited by 17 publications

References 17 publications

Parathyroid hormone enhances gap healing and osseointegration in orthopedic porous coated titanium implants: a correlative micro-computed tomographic, histomorphometric and biomechanical analysis

Parathyroid hormone enhances gap healing and osseointegration in orthopedic porous coated titanium implants: a correlative micro-computed tomographic, histomorphometric and biomechanical analysis

Multiple Contiguous-Level Cervical Disc Arthroplasties: Unique Considerations

Clinical and radiographic outcomes of cervical disc arthroplasty with Prestige-LP Disc: a minimum 6-year follow-up study

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