Impending Contraceptives That Might Be a Positive Methodology Towards the Male Contraception

Abstract

The total population has been developing dramatically; be that as it may, right now, the decisions for male contraception are restricted. This study investigates continuous explores of male contraceptives. This study article is primarily based on the thought of contraception that must be needed toward the increasing population and giving the ideal strategy to control the fertility of humans and animals. This review featured the recent oral male contraceptives that may be revolutionary products in our world as means of contraception. The audit article considers that these contraceptives are customarily utilized for their spermicidal activities and their fundamental hormones of the awkwardness for fertility and the mechanism of activity of the impact of the antifertility of contraceptives. The present study offers up-to-date data gathered on the contraceptives used for anti-fertility activity in males. The goal of this study is to spotlight the work on the anti-fertility effect of contraceptives. Therefore these products can provide options and lowering fertility would be higher than different contraceptives. This article can also assist investigators in developing the newer contraceptive preparation for anti-fertility activity in males. The innovations in this field are important to focus on current, more intense medication having a less detrimental effect on the body function and that can be administrable on its entity, less expensive, and quite reversible.

Application of Mathematical Modeling and Physico-Chemical Analysis Methods in the Prediction of Biological Activity and Quality Control of Gossypol Derivatives

“…4, the values of antitumor activity are as close as possible to "1" (Pa from 0.8 to 0.9), which may indicate a high probability of a positive effect when using GAA derivatives as part of antitumor agents [27]. A review of scientific publications and the results of experiments conducted in China [28] indicate the ability of drugs containing Gossypol to suppress spermatogenesis, causing azoospermia. Our QSAR study confirmed the literature data: the probability to be active (Pa) for the majority (the exception are VMS 2 and 9) of gossypol derivatives was in the range from 0.6 to 0.8 (blue circles in see fig.…”