Impedance characterization of biocompatible hydrogel suitable for biomimetic lipid membrane applications

Mech-Dorosz, Agnieszka; Khan, Muhammad Salman; Mateiu, Ramona Valentina; Hélix-Nielsen, Claus; Emnéus, Jenny; Heiskanen, Arto

doi:10.1016/j.electacta.2021.137917

Cited by 8 publications

(8 citation statements)

References 49 publications

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“…For reference, conductivity values typically reported in biomaterials designed for charge transport through incorporation of conducting polymers range from 10 −4 −10 0 S/m. 51 We note that the Nyquist plots for all gels and the electrolyte control showed a small loop at high frequency with a width of approximately 200 Ω. This feature is often attributed to the capacitance of the electrical double layer at electrolyte interfaces.…”

Section: ■ Results and Discussionmentioning

confidence: 68%

“…We note that the Nyquist plots for all gels and the electrolyte control showed a small loop at high frequency with a width of approximately 200 Ω. This feature is often attributed to the capacitance of the electrical double layer at electrolyte interfaces . However, we were unable to obtain repeatable and reliable measurements of this region, so to avoid overinterpretation, we have excluded this feature from our models.…”

Section: Results and Discussionmentioning

confidence: 99%

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3,4-Ethylenedioxythiophene Hydrogels: Relating Structure and Charge Transport in Supramolecular Gels

Salter,

Wojciechowski,

McLean

et al. 2024

Chem. Mater.

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Ionic charge transport is a ubiquitous language of communication in biological systems. As such, bioengineering is in constant need of innovative, soft, and biocompatible materials that facilitate ionic conduction. Low molecular weight gelators (LMWGs) are complex self-assembled materials that have received increasing attention in recent years. Beyond their biocompatible, self-healing, and stimuli responsive facets, LMWGs can be viewed as a “solid” electrolyte solution. In this work, we investigate 3,4-ethylenedioxythiophene (EDOT) as a capping group for a small peptide library, which we use as a system to understand the relationship between modes of assembly and charge transport in supramolecular gels. Through a combination of techniques including small-angle neutron scattering (SANS), NMR-based Van’t Hoff analysis, atomic force microscopy (AFM), rheology, four-point probe, and electrochemical impedance spectroscopy (EIS), we found that modifications to the peptide sequence result in distinct assembly pathways, thermodynamic parameters, mechanical properties, and ionic conductivities. Four-point probe conductivity measurements and electrochemical impedance spectroscopy suggest that ionic conductivity is approximately doubled by programmable gel assemblies with hollow cylinder morphologies relative to gels containing solid fibers or a control electrolyte. More broadly, it is hoped this work will serve as a platform for those working on charge transport of aqueous soft materials in general.

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Section: ■ Results and Discussionmentioning

confidence: 68%

Section: Results and Discussionmentioning

confidence: 99%

3,4-Ethylenedioxythiophene Hydrogels: Relating Structure and Charge Transport in Supramolecular Gels

Salter,

Wojciechowski,

McLean

et al. 2024

Chem. Mater.

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“…The impedance profiles of the bigels are provided in Figure 5 . The impedance profiles showed typical capacitive behavior; wherein there is a higher impedance in the low-frequency range that reduces to a basal level in the high-frequency range [ 51 ]. The analysis of the impedance profiles suggested that the control bigel (BG0) was relatively higher than the dp-CNC-containing bigels, except BG3.…”

Section: Resultsmentioning

confidence: 99%

Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin

Shaikh

Anis

Poulose

et al. 2022

Gels

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Bigels are biphasic semisolid systems that have been explored as delivery vehicles in the food and pharmaceutical industries. These formulations are highly stable and have a longer shelf-life than emulsions. Similarly, cellulose-based hydrogels are considered to be ideal for these formulations due to their biocompatibility and flexibility to mold into various shapes. Accordingly, in the present study, the properties of an optimized guar gum hydrogel and sesame oil/candelilla wax oleogel-based bigel were tailored using date palm-derived cellulose nanocrystals (dp-CNC). These bigels were then explored as carriers for the bioactive molecule moxifloxacin hydrochloride (MH). The preparation of the bigels was achieved by mixing guar gum hydrogel and sesame oil/candelilla wax oleogel. Polarizing microscopy suggested the formation of the hydrogel-in-oleogel type of bigels. An alteration in the dp-CNC content affected the size distribution of the hydrogel phase within the oleogel phase. The colorimetry studies revealed the yellowish-white color of the samples. There were no significant changes in the FTIR functional group positions even after the addition of dp-CNC. In general, the incorporation of dp-CNC resulted in a decrease in the impedance values, except BG3 that had 15 mg dp-CNC in 20 g bigel. The BG3 formulation showed the highest firmness and fluidity. The release of MH from the bigels was quasi-Fickian diffusion mediated. BG3 showed the highest release of the drug. In summary, dp-CNC can be used as a novel reinforcing agent for bigels.

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“…Furthermore, the Nyquist plot shows finite space diffusion, denoted by a diffusive straight line (Figures S7C, D and A, right). It is worth pointing out that these changes in the impedance could be attributed to the structural variation of the polymerized eutectogels, as was highlighted in other works . However, the disturbance of the hydrogen bonding interactions between menthol and the fatty acid, making the water or other salts act as a second HBD in the eutectogel matrix, could also be a contributing factor .…”

mentioning

confidence: 76%

“…It is worth pointing out that these changes in the impedance could be attributed to the structural variation of the polymerized eutectogels, as was highlighted in other works. 38 However, the disturbance of the hydrogen bonding interactions between menthol and the fatty acid, making the water or other salts act as a second HBD in the eutectogel matrix, could also be a contributing factor. 35 We hypothesized that the HES could form micelles when the eutectogels are swollen, creating many negatively charged points and giving rise to a double-layer capacitance effect.…”

mentioning

confidence: 99%

Hydrophobic Eutectogels as Electrodes for Underwater Electromyography Recording

de Lacalle,

Picchio,

Dominguez-Alfaro

et al. 2023

ACS Materials Lett.

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Underwater recording remains a critical challenge in bioelectronics because traditional flexible electrodes can not fulfill essential requirements such as stability and steady conductivity in aquatic environments. Herein, we show the use of elastic gels made of hydrophobic natural eutectic solvents as water-resistant electrodes. These eutectogels are designed with tailorable mechanical properties via one-step photopolymerization of acrylic monomers in different eutectic mixtures composed of fatty acids and menthol. The low viscosity of the eutectics turns the formulations into suitable inks for 3D printing, allowing fast manufacturing of complex objects. Furthermore, the hydrophobic nature of the building blocks endows the eutectogels with excellent stability and low water uptake. The obtained flexible eutectogel electrodes can record real-time electromyography (EMG) signals with low interference in the air and underwater.

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Impedance characterization of biocompatible hydrogel suitable for biomimetic lipid membrane applications

Cited by 8 publications

References 49 publications

3,4-Ethylenedioxythiophene Hydrogels: Relating Structure and Charge Transport in Supramolecular Gels

3,4-Ethylenedioxythiophene Hydrogels: Relating Structure and Charge Transport in Supramolecular Gels

Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin

Hydrophobic Eutectogels as Electrodes for Underwater Electromyography Recording

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