Impairment of the Diurnal Fibrinolytic Response in Man

Abstract

Diurnal patterns of plasma euglobulin fibrinolytic activity, estimated by the fibrin plate method, were determined in groups of young normal and older normal subjects, in subjects with type IV hyperlipoproteinemia, and in subjects with coronary artery disease who had normal lipid profiles. The marked diumal increases in fibrinolytic activity observed in the young normal subjects were significantly reduced in a large percent of the older normal subjects and in most of the subjects with coronary artery disease or type IV hyperlipoproteinemia. Although not conclusive, these findings were compatible with the hypothesis that an impairment in the responsiveness of the fibrinolytic system may be related to the development of coronary artery disease.

The Influence of Coronary Angiography and Angioplasty on Parameters of Hemostasis and Fibrinolysis

“…However, sampling for detailed investigations of hemostasis and thrombosis should be subjected to stringent precepts as several parameters are influenced by various circumstances. Some of these influences have previously been described, for example the hour of blood sampling (11)(12)(13)(14)(15)(16)(17)(18), mental stress (19)(20)(21), administration of drugs (22,23), including rontgen contrast agents (24)(25)(26)(27)(28)(29)(30)(31), the temporary presence in the circulation of foreign matters such as heart catheters (30) and the existence of hematomas, as for example at the puncture site after a catheterization. It is therefore generally advocated that blood samples are taken at a carefully stipulated time of the day in rested and fasted patients who are in a recumbent posture, who do not take any drugs and who have not recently undergone any surgery.…”