Ethyl Alcohol Enhances Plasminogen Activator Secretion by Endothelial Cells

Ethanol‐Induced Up‐Regulation of Candidate Plasminogen Receptor Annexin II in Cultured Human Endothelial Cells

“…Furthermore, we also recently described the transcriptional downregulation of plasminogen activator inhibitor type-1 gene expression by low ethanol (Grenett, 2000). Several other in vitro studies have described the ethanol-induced increased expression of one or more of the fibrinolytic proteins that may contribute to the increased net expression of surfacelocalized EC fibrinolytic activity, which includes the ethanol-induced increase in t-PA secretion in cultured bovine aortic ECs (Laug, 1983) and increase in t-PA and decrease in plasminogen activator inhibitor type-1 mRNA in cultured HUVECs. Regulation of the Ann-II gene expression by a variety of other inducers has been reported.…”

The Primary Prevention of Coronary Heart Disease in Women

“…118 Such antithrombotic effects of alcohol may increase the risk of hemorrhagic stroke, 25 however, and even moderate alcohol consumption has been linked to hypertension. 119 Furthermore, alcohol consumption may increase the risk of breast cancer, 120 and heavy consumption is the second leading preventable cause of all deaths in the United States.…”

Ethanol

“…892,893 In the Northern Manhattan Stroke Study the association between moderate ethanol consumption and reduced stroke risk was independent of the HDL cholesterol level. [896][897][898][899][900] In other studies, however, moderate ethanol consumption increased levels of prostacyclin, 901,902 decreased platelet function, 903-910 decreased plasma fibrinogen levels, 911 stimulated release of endothelin from endothelial cells, 912 and increased plasma levels of endogenous tissue plasminogen activator. 894 Lp(a) lipoprotein levels, which correlate with the extent of carotid atherosclerosis, are reduced by ethanol intake.…”