Impairment of neutrophil chemotaxis by serum from patients with chronic lymphoproliferative disease.

Jayaswal, U; Roper, S; Roath, S.

doi:10.1136/jcp.36.4.449

Cited by 8 publications

(4 citation statements)

References 21 publications

(2 reference statements)

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“…In addition to intrinsic PMN defects, certain unknown factors in the serum of patients with cancer appear to reduce the capacity of PMN to perform their main functions by blocking their Fc receptors373 or by reducing PMN chemoattraction; this has been reported in hepatocellular carcinoma,374 in other solid tumors,375–377 and in lymphoproliferative disease 339, 376, 378, 379. Serum from patients with solid tumors reduces the cytostatic activity of normal PMN 34.…”

Section: Does Defective Pmn Function Encourage the Growth Of A Canmentioning

confidence: 99%

Polymorphonuclear neutrophils and cancer: Intense and sustained neutrophilia as a treatment against solid tumors

Souto

Vilá

Brú

2011

Medicinal Research Reviews

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Polymorphonuclear neutrophils (PMN) are the most abundant circulating immune cells and represent the first line of immune defense against infection. This review of the biomedical literature of the last 40 years shows that they also have a powerful antitumoral effect under certain circumstances. Typically, the microenvironment surrounding a solid tumor possesses many of the characteristics of chronic inflammation, a condition considered very favorable for tumor growth and spread. However, there are many circumstances that shift the chronic inflammatory state toward an acute inflammatory response around a tumor. This shift seems to convert PMN into very efficient anticancer effector cells. Clinical reports of unexpected antitumoral effects linked to the prolonged use of granulocyte colony-stimulating factor, which stimulates an intense and sustained neutrophilia, suggest that an easy way to fight solid tumors would be to encourage the development of intense peritumoral PMN infiltrates. Specifically designed clinical trials are urgently needed to evaluate the safety and efficacy of such drug-induced neutrophilia in patients with solid tumors. This antitumoral role of neutrophils may provide new avenues for the clinical treatment of cancer.

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Section: Does Defective Pmn Function Encourage the Growth Of A Canmentioning

confidence: 99%

Polymorphonuclear neutrophils and cancer: Intense and sustained neutrophilia as a treatment against solid tumors

Souto

Vilá

Brú

2011

Medicinal Research Reviews

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“…6-11 Our study demonstrated notable qualitative differences in phagocytosis against common bacterial but not fungal pathogens between the CLL patients and age-matched controls. Due to the small number of patients with infections, we were not able to identify a relationship between impaired PMN killing response and infection risk.…”

Section: Resultsmentioning

confidence: 63%

“…1-5 However, genetic or acquired deficiencies in innate cellular immune responses in heavily pretreated CLL patients may predispose them to severe, frequently fulminant infections. 6-11 Therefore, we sought to characterize the qualitative polymorphonuclear neutrophil (PMN)-associated immune impairment in CLL patients with a focus on differences in phagocytic killing by PMNs of key nonopsonized bacterial ( Staphylococcus aureus and Pseudomonas aeruginosa ) and fungal ( Candida albicans and Aspergillus fumigatus ) pathogens that frequently cause severe infections in CLL patients.…”

Section: Introductionmentioning

confidence: 99%

Impaired bactericidal but not fungicidal activity of polymorphonuclear neutrophils in patients with chronic lymphocytic leukemia

Kontoyiannis

Georgiadou²,

Wierda

et al. 2013

Leukemia & Lymphoma

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We examined the qualitative polymorphonuclear neutrophil (PMN)-associated immune impairment in patients with chronic lymphocytic leukemia (CLL) by characterizing phagocytic killing of key nonopsonized bacterial (Staphylococcus aureus and Pseudomonas aeruginosa) and fungal (Candida albicans and Aspergillus fumigatus) pathogens. Neutrophils were collected from 47 nonneutropenic CLL patients (PMN count > 1000/mm3), and age-matched and young healthy controls (five each). A subset of patients (13%) had prior or subsequent infections. We found that the CLL patients had diminished PMN microbicidal response against bacteria but not against fungi than did the controls. Compared to patients with effective PMN responses, we did not identify differences of basal PMN pathogen-associated molecular pattern receptor gene expression, soluble pathogen-associated molecular pattern gene expression, or inflammatory cytokine signatures in patients with impaired PMN responses when PMNs were analyzed in multiplex real-time polymerase chain reaction assays. However, differences in PMN microbicidal response against A. fumigatus in CLL patients were associated with the degree of hypogammaglobulinemia.

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“…In the innate immune response to tissue injury or infection, neutrophils are recruited to the inflammatory site. Neutrophil chemotaxis inhibitors were found in the sera of myeloma patients ( 22 ). In immunotherapy against MM, positive regulation of T-cell proliferation played a crucial role.…”

Section: Discussionmentioning

confidence: 99%

An emerging prognosis prediction model for multiple myeloma: Hypoxia-immune related microenvironmental gene signature

Qiu

et al. 2022

Front. Oncol.

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Multiple myeloma (MM), a hematologic malignancy, is characterized by malignant plasma cells clonal proliferation. Many evidences indicated the indirect interaction between hypoxic environment and immune state in MM tumorigenesis, but the underlying mechanism remains unclear. MM-related datasets were downloaded from the Gene Expression Omnibus (GEO) database. The R packages were applied for screening protective differentially expressed genes (DEGs) and risk DEGs. The signature was constructed based the most prognostic gene signature in the training and assessed in the validation cohorts. The immune cell infiltration, the expression of the HLA family and immune checkpoint genes inside the low- and high-risk groups were compared to determine the differences in immune infiltration and immunotherapy responses. Moreover, the expression of HLA families and immune checkpoints inside the low- and high-risk groups was markedly disordered. The results indicated hypoxia- and immune-related genes, including CHRDL1, DDIT4, DNTT, FAM133A, MYB, PRR15, QTRT1, and ZNF275, were identified and used to construct a prognostic signature. Role of DDIT4 in multiple myeloma was confirmed in vivo and in vitro. DDIT4 knockdown inhibited MM cell viability, migration and invasion potential as well as promoted myeloma cells apoptosis under hypoxia. Taken together, our study may contribute to the treatment and prognosis prediction of MM.

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Impairment of neutrophil chemotaxis by serum from patients with chronic lymphoproliferative disease.

Cited by 8 publications

References 21 publications

Polymorphonuclear neutrophils and cancer: Intense and sustained neutrophilia as a treatment against solid tumors

Polymorphonuclear neutrophils and cancer: Intense and sustained neutrophilia as a treatment against solid tumors

Impaired bactericidal but not fungicidal activity of polymorphonuclear neutrophils in patients with chronic lymphocytic leukemia

An emerging prognosis prediction model for multiple myeloma: Hypoxia-immune related microenvironmental gene signature

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