Impairment of Long-Term Plasticity of Cerebellar Purkinje Cells Eliminates the Effect of Anodal Direct Current Stimulation on Vestibulo-Ocular Reflex Habituation

Das, Suman; Spoor, Marcella; Sibindi, Tafadzwa; Holland, Peter Anthony; Schonewille, Martijn; Zeeuw, Chris I. De; Frens, Maarten A.; Donchin, Opher

doi:10.3389/fnins.2017.00444

Cited by 12 publications

(5 citation statements)

References 42 publications

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“…Since anodal tDCS induces long-term potentiation (LTP)-like plasticity, and improved learning, the results provide further evidence against the long-standing view that long-term depression (LTD) at the parallel fiber-Purkinje cell synapse is the only and the essential kind of plasticity underlying learning in the cerebellar cortex [233]. In accordance, a recent study in mice found that anodal tDCS effects depend on LTP and the intrinsic plasticity of Purkinje cells in VOR habituation [234]. This has been further supported in recent years by Johansson et al (2015) and Gutierres-Castellanos et al (2017) [235, 236].…”

Section: Non-invasive Stimulation In Humanssupporting

confidence: 53%

Consensus Paper: Experimental Neurostimulation of the Cerebellum

et al. 2019

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The cerebellum is best known for its role in controlling motor behaviors. However, recent work supports the view that it also influences non-motor behaviors. The contribution of the cerebellum towards different brain functions is underscored by its involvement in a diverse and increasing number of neurological and neuropsychiatric conditions including ataxia, dystonia, essential tremor, Parkinson’s disease (PD), epilepsy, stroke, multiple sclerosis, autism spectrum disorders, dyslexia, attention deficit hyperactivity disorder (ADHD), and schizophrenia. Although there are no cures for these conditions, cerebellar stimulation is quickly gaining attention for symptomatic alleviation, as cerebellar circuitry has arisen as a promising target for invasive and non-invasive neuromodulation. This consensus paper brings together experts from the fields of neurophysiology, neurology, and neurosurgery to discuss recent efforts in using the cerebellum as a therapeutic intervention. We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.

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Section: Non-invasive Stimulation In Humanssupporting

confidence: 53%

Consensus Paper: Experimental Neurostimulation of the Cerebellum

et al. 2019

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“…The stimulation in the cerebellar vermis, in reaching the prefrontal cortex, likely coursed through the fastigial nucleus and then to the thalamus (Bostan et al, 2013; Lisberger and Thach, 2013). Stimulation of Purkinje cells, in the outermost layer of the cerebellum, leads to changes in the cerebellar output, which in turn modulates the output of deep cerebellar nuclei (DCN) (Oulad Ben Taib and Manto, 2013, 2016; Das et al, 2017). Because inputs from Purkinje cells to the DCN are inhibitory, increased activation of Purkinje cells with high frequency stimulation (Maeda et al, 2000b; Hallett, 2007) inhibits the tonic activity of the DCN.…”

Section: Discussionmentioning

confidence: 99%

State-Dependent Entrainment of Prefrontal Cortex Local Field Potential Activity Following Patterned Stimulation of the Cerebellar Vermis

Tremblay

Chapman

Courtemanche

2019

Front. Syst. Neurosci.

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The cerebellum is involved in sensorimotor, cognitive, and emotional functions through cerebello-cerebral connectivity. Cerebellar neurostimulation thus likely affects cortical circuits, as has been shown in studies using cerebellar stimulation to treat neurological disorders through modulation of frontal EEG oscillations. Here we studied the effects of different frequencies of cerebellar stimulation on oscillations and coherence in the cerebellum and prefrontal cortex in the urethane-anesthetized rat. Local field potentials were recorded in the right lateral cerebellum (Crus I/II) and bilaterally in the prefrontal cortex (frontal association area, FrA) in adult male Sprague-Dawley rats. Stimulation was delivered to the cerebellar vermis (lobule VII) using single pulses (0.2 Hz for 60 s), or repeated pulses at 1 Hz (30 s), 5 Hz (10 s), 25 Hz (2 s), and 50 Hz (1 s). Effects of stimulation were influenced by the initial state of EEG activity which varies over time during urethane-anesthesia; 1 Hz stimulation was more effective when delivered during the slow-wave state (Stage 1), while stimulation with single-pulse, 25, and 50 Hz showed stronger effects during the activated state (Stage 2). Single-pulses resulted in increases in oscillatory power in the delta and theta bands for the cerebellum, and in frequencies up to 80 Hz in cortical sites. 1 Hz stimulation induced a decrease in 0–30 Hz activity and increased activity in the 30–200 Hz range, in the right FrA. 5 Hz stimulation reduced power in high frequencies in Stage 1 and induced mixed effects during Stage 2.25 Hz stimulation increased cortical power at low frequencies during Stage 2, and increased power in higher frequency bands during Stage 1. Stimulation at 50 Hz increased delta-band power in all recording sites, with the strongest and most rapid effects in the cerebellum. 25 and 50 Hz stimulation also induced state-dependent effects on cerebello-cortical and cortico-cortical coherence at high frequencies. Cerebellar stimulation can therefore entrain field potential activity in the FrA and drive synchronization of cerebello-cortical and cortico-cortical networks in a frequency-dependent manner. These effects highlight the role of the cerebellar vermis in modulating large-scale synchronization of neural networks in non-motor frontal cortex.

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“…Although tACS and tDCS modulate cerebellar plasticity and functional connectivity, these electric techniques most likely operate in a different way than the transcranial magnetic stimulation (TMS) techniques such as cTBS [10]. Obviously, more will be learned from animal models [15].…”

Section: Introductionmentioning

confidence: 99%

Consensus Paper: Cerebellum and Emotion

et al. 2016

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The field of non-invasive stimulation of the cerebellum is quickly expanding. The anatomical structure of the cerebellum with a high density of neurons in the superficial layer, its electrical properties, and its participation in numerous closed-loop circuits involved in motor, cognitive, and affective operations both in children and in adults make of the cerebellum a target with very high potential for neuromodulation of both cerebellar and extra-cerebellar disorders, in neurology, psychiatry, and neurosurgery. A common research effort is required to extract the optimal parameters of stimulation and to identify how non-invasive stimulation of the cerebellum modifies cerebellar plasticity and functional connectivity in remote cortical and subcortical areas. A patient stratification should be considered.

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Impairment of Long-Term Plasticity of Cerebellar Purkinje Cells Eliminates the Effect of Anodal Direct Current Stimulation on Vestibulo-Ocular Reflex Habituation

Cited by 12 publications

References 42 publications

Consensus Paper: Experimental Neurostimulation of the Cerebellum

Consensus Paper: Experimental Neurostimulation of the Cerebellum

State-Dependent Entrainment of Prefrontal Cortex Local Field Potential Activity Following Patterned Stimulation of the Cerebellar Vermis

Consensus Paper: Cerebellum and Emotion

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