Consensus Paper: Cerebellum and Emotion

Adamaszek, Michael; D’Agata, Federico; Ferrucci, Roberta; Habas, Christophe; Keulen, Stefanie; Kirkby, Kenneth C.; Leggio, Maria; Mariën, Peter; Molinari, Marco; Moulton, Eric A.; Orsi, Laura; Overwalle, Frank Van; Papadelis, Christos; Sacchetti, Benedetto; Schutter, Dennis J.L.G.; Styliadis, Charis; Verhoeven, Jo

doi:10.1007/s12311-016-0815-8

Cited by 426 publications

(369 citation statements)

References 220 publications

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“…Lobules VII–X of the vermis have also been proposed to serve as an interface among sensory processing, emotional states and motor responses, due to the anatomical and functional connectivity with the amygdala and other areas of the emotional brain (Adamaszek et al . ). Therefore, it is plausible for the cerebellum to modulate the reward response in other areas of the striatum–cortico–limbic circuitry.…”

Section: Discussionmentioning

confidence: 97%

The role of the cerebellum in drug‐cue associative memory: functional interactions with the medial prefrontal cortex

Gil‐Miravet

Guarque-Chabrera

Carbó-Gas

et al. 2018

Eur J of Neuroscience

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Drug‐induced Pavlovian memories are thought to be crucial for drug addiction because they guide behaviour towards environments with drug availability. Drug‐related memory depends on persistent changes in dopamine‐glutamate interactions in the medial prefrontal cortex (mPFC), basolateral amygdala, nucleus accumbens core and hippocampus. Recent evidence from our laboratory indicated that the cerebellum is also a relevant node for drug‐cue associations. In the present study, we tested the role that specific regions of the cerebellum and mPFC play in the acquisition of cocaine‐induced preference conditioning. Quinolinic acid was used to manage a permanent deactivation of lobule VIII in the vermis prior to conditioning. Additionally, lidocaine was infused into the prelimbic and infralimbic (IL) cortices for reversible deactivation before every training session. The present findings show, for the first time, that the cerebellum and mPFC might act together in order to acquire drug‐cue Pavlovian associations. Either a dorsal lesion in lobule VIII or an IL deactivation encouraged cocaine‐induced preference conditioning. Moreover, simultaneous IL‐cerebellar deactivation prevented the effect of either of the separate deactivations. Therefore, similar to the IL cortex, neural activity in the cerebellum may be crucial for ensuring inhibitory control of the expression of cocaine‐related memories.

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Section: Discussionmentioning

confidence: 97%

The role of the cerebellum in drug‐cue associative memory: functional interactions with the medial prefrontal cortex

Gil‐Miravet

Guarque-Chabrera

Carbó-Gas

et al. 2018

Eur J of Neuroscience

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“…We speculate that there may be a more profound mechanism correlation between psychiatric symptoms and some soft signs like balance and TG impairment. Lobules VI‐VII within the vermis are part of the limbic cerebellum which participates in emotional processing; dysregulation in these areas can result in affective disorders . Meanwhile, vermis of the cerebellum is also involved in control of the midline balance .…”

Section: Discussionmentioning

confidence: 99%

“…Lobules VI-VII within the vermis are part of the limbic cerebellum which participates in emotional processing; dysregulation in these areas can result in affective disorders. 37,38 Meanwhile, vermis of the cerebellum is also involved in control of the midline balance. 12,39 When vermis affected, patients are more likely to develop mental symptoms and may be accompanied by signs associated with balance disorders.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of patients with essential tremor or essential tremor plus

et al. 2020

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Background The International Parkinson and Movement Disorder Society introduced the category of essential tremor (ET)‐plus in its new ET classification scheme, but how the clinical correlates of ET‐plus differ from those of “pure” ET is unclear. By comparing the clinical characteristics of ET and ET‐plus patients, we expect to better understand the impact and invoked questions of the new classification on clinical practice. Methods We reviewed the medical records of 280 ET syndrome patients in an ongoing cross‐sectional study in a Chinese population and reclassified them according to the new criteria. Clinico‐demographic characteristics were compared between ET and ET‐plus patients. Risk factors of diagnosis of ET‐plus were explored using logistic regression. Results A total of 121 patients (50.8%) were reclassified as having ET and 117 as having ET‐plus. ET‐plus group was significantly older at tremor onset, less educated, and more likely to have cranial tremor, depression symptom, anxiety symptom, and probable REM sleep behavior disorder. ET‐plus group also showed more severe upper limb tremor and cognition impairment. Regression analysis identified four independent risk factors associated with ET‐plus: late tremor onset (OR 3.04, 95%CI 1.60‐5.79), less educated (OR 0.91, 95%CI 0.85‐0.97), severe upper limb tremor (OR 2.46, 95%CI 1.30‐4.62), and presence of cranial tremor (OR 2.30, 95%CI 1.20‐4.41). Conclusions The new classification scheme emphasized that ET syndrome is heterogeneous. ET‐plus cannot be seen as a subtype or a diagnosis of ET syndrome, but rather as a placeholder, representing an area of current scientific uncertainty.

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“…As the cerebellum and insula are both associated with emotional processing (46, 47), a lower functional interaction may be the underlying substrate of the emotional changes and altered emotional processing often reported in PSP (48). Finally, we observed increased rsFC between the salience and executive-control RSNs in patients with CBS, but not in those with PSP.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Resting-State Functional Connectivity in Progressive Supranuclear Palsy and Corticobasal Syndrome

et al. 2017

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BackgroundPathological and MRI-based evidence suggests that multiple brain structures are likely to be involved in functional disconnection between brain areas. Few studies have investigated resting-state functional connectivity (rsFC) in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). In this study, we investigated within- and between-network rsFC abnormalities in these two conditions.MethodsTwenty patients with PSP, 11 patients with CBS, and 16 healthy subjects (HS) underwent a resting-state fMRI study. Resting-state networks (RSNs) were extracted to evaluate within- and between-network rsFC using the Melodic and FSLNets software packages.ResultsIncreased within-network rsFC was observed in both PSP and CBS patients, with a larger number of RSNs being involved in CBS. Within-network cerebellar rsFC positively correlated with mini-mental state examination scores in patients with PSP. Compared to healthy volunteers, PSP and CBS patients exhibit reduced functional connectivity between the lateral visual and auditory RSNs, with PSP patients additionally showing lower functional connectivity between the cerebellar and insular RSNs. Moreover, rsFC between the salience and executive-control RSNs was increased in patients with CBS compared to HS.ConclusionThis study provides evidence of functional brain reorganization in both PSP and CBS. Increased within-network rsFC could represent a higher degree of synchronization in damaged brain areas, while between-network rsFC abnormalities may mainly reflect degeneration of long-range white matter fibers.

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Consensus Paper: Cerebellum and Emotion

Cited by 426 publications

References 220 publications

The role of the cerebellum in drug‐cue associative memory: functional interactions with the medial prefrontal cortex

The role of the cerebellum in drug‐cue associative memory: functional interactions with the medial prefrontal cortex

Clinical characteristics of patients with essential tremor or essential tremor plus

Abnormal Resting-State Functional Connectivity in Progressive Supranuclear Palsy and Corticobasal Syndrome

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