Impairment of central mediation of the arterial baroreflex by acute ethanol administration

Zhang, Xin; Abdel-Rahman, A-R.A.; Wooles, W. R.

doi:10.1016/0741-8329(88)90056-0

Cited by 15 publications

(8 citation statements)

References 17 publications

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“…These data suggest this area is involved in the baroreceptor reflex-mediated bradycardia observed after either parenteral 6 -7 - 12 or oral 5 administration of ethanol. Since the RVL medulla is relatively distant anatomically from the NTS 23 or the DMV, it is unlikely that ethanol leakage to either or both areas could account for the impairment of baroreceptor reflex-mediated bradycardia.…”

Section: Discussionmentioning

confidence: 75%

“…12 This data provided indirect evidence of a possible impairment of central mediation in the baroreceptor reflex control of heart rate. In the present study, we examined the effects of microinjection of ethanol in some CNS sites that are possibly involved in the baroreceptor reflex arc.…”

Section: Discussionmentioning

confidence: 96%

“…7 Since sympathetic efferent discharge was recorded from nerve stimulation suggested ethanol impairs the central mediation of baroreceptor reflex responses. 12 The sites of action at which ethanol acts within the central nervous system (CNS) are not known.…”

Section: Impairment Of Baroreceptor Reflex Control Of Heart Rate But mentioning

confidence: 99%

“…- 12 We also microinjected ethanol into the anterior and posterior hypothalamus and the rostral ventrolateral medulla (RVL), areas known to be involved in the control of cardiovascular function, to determine if the effects of ethanol were specific to one or more of these areas.…”

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confidence: 99%

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Impairment of baroreceptor reflex control of heart rate but not sympathetic efferent discharge by central neuroadministration of ethanol.

1989

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We investigated the acute hemodynamic effects of ethanol microinjection into brain areas known to influence cardiovascular function and reflexes. In chloralose-anesthetized rats, ethanol had no effect on baseline mean arterial pressure, heart rate, or sympathetic efferent discharge when microinjected into the nucleus tractus solitarius, the dorsal motor nucleus of the vagus, the rostral ventrolateral medulla, or the posterior hypothalamus. On the other hand, ethanol microinjection into the anterior hypothalamus caused a site-dependent pressor effect and an increase in sympathetic efferent discharge. Baroreceptor heart rate response but not sympathetic efferent discharge response was impaired by ethanol microinjection into the nucleus tractus solitarius, the dorsal motor nucleus of the vagus, and the rostral ventrolateral medulla, suggesting that ethanol involves one or more of these areas in its inhibitory effect on baroreceptor heart rate response and that ethanol has a selective action on baroreceptor reflex control of heart rate. The findings that 1) the effect was dose dependent and 2) injection of ethanol outside of, or an equal volume of cerebrospinal fluid into, the nucleus tractus solitarius had no effect on the response strongly suggest that the observed effect on baroreceptor heart rate response was ethanol mediated. Ethanol microinjection into the dorsal motor nucleus of the vagus impaired the heart rate response, thus raising the possibility that leakage of ethanol to that area from the nucleus tractus solitarius might have contributed to its effect. These findings show that ethanol has a pressor and sympathoexcitatory site of action within the anterior hypothalamus and that it selectively impairs baroreceptor heart rate response via a central site of action; the mechanisms by which ethanol produces these effects remain to be elucidated.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 96%

Section: Impairment Of Baroreceptor Reflex Control Of Heart Rate But mentioning

confidence: 99%

mentioning

confidence: 99%

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Impairment of baroreceptor reflex control of heart rate but not sympathetic efferent discharge by central neuroadministration of ethanol.

1989

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“…This is especially true in the case of SUDs, wherein individuals with SUDs have been shown to have lower resting HRV than individuals without substance use problems (Ingjaldsson, Laberg, & Thayer, 2003; Weise, Müller, Krell, Kielstein, & Koch, 1986). While this association could potentially be a factor of the direct pharmacological actions of alcohol and other drugs, or a sequela of lifestyles attendant with chronic heavy substance use, some suggest this is not the case (Peterson, Pihl, Seguin, Finn, & Stewart, 1993; Zhang, Abdel-Rahman, & Wooles, 1988). The fact that individuals with a variety of mental disorders also exhibit lower resting HRV in the absence of neurotoxic substances, speaks to this postulate.…”

Section: Hrv As Marker Of Health Affective Regulation and Sud Problemsmentioning

confidence: 99%

Heart rate variability biofeedback: Theoretical basis, delivery, and its potential for the treatment of substance use disorders

Eddie

Vaschillo

et al. 2015

Addiction Research & Theory

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Heart rate variability biofeedback (HRV BFB) is a biobehavioural clinical intervention that is gaining growing empirical support for the treatment of a number of psychological disorders, several of which are highly comorbid with substance use disorders (SUDs). The present article reviews the autonomic nervous system bases of two key processes implicated in the formation and maintenance of addictive pathology—affect dysregulation and craving—and asks if HRV BFB may be an effective intervention to ameliorate autonomic nervous system dysregulation in these processes, and as such, prove to be an effective intervention for SUDs. A detailed description of HRV BFB and its delivery is provided. Preliminary evidence suggests HRV BFB may be an effective addendum to current first-line SUD treatments, though no firm conclusions can be drawn at this time; more research is needed.

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Central Neural Mechanisms in the Cardiovascular Effects of Ethanol

Kunos¹,

Varga²,

Zakhari³

1992

Central Neural Mechanisms in Cardiovascular Regulation

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Impairment of central mediation of the arterial baroreflex by acute ethanol administration

Cited by 15 publications

References 17 publications

Impairment of baroreceptor reflex control of heart rate but not sympathetic efferent discharge by central neuroadministration of ethanol.

Impairment of baroreceptor reflex control of heart rate but not sympathetic efferent discharge by central neuroadministration of ethanol.

Heart rate variability biofeedback: Theoretical basis, delivery, and its potential for the treatment of substance use disorders

Central Neural Mechanisms in the Cardiovascular Effects of Ethanol

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