Impairment in long-term retention but not short-term performance on a water maze reversal task following hippocampal or mediodorsal striatal n-methyl-d-aspartate receptor blockade.

Holahan, Matthew R.; Taverna, Franco A.; Emrich, Stephen M.; Louis, Meira; Muller, Robert U.; Roder, John; McDonald, Robert J.

doi:10.1037/0735-7044.119.6.1563

Cited by 19 publications

(14 citation statements)

References 66 publications

(83 reference statements)

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“…However, it is noteworthy that several other brain regions, in addition to the hippocampus, have been implicated in different aspects of rat and human spatial performance, including subregions of the striatum and the frontal cortex (Devan et al 1996;Holahan et al 2005;Kolb et al 1983;Maguire et al 1998;for review, see, D'Hooge and De Deyn 2001). Therefore, the apparently independent effects of age on aspects of Morris maze performance of mice, such as late acquisition, the probe test, and reversal, could very well reflect differing degrees of involvement of these regional targets in aging.…”

Section: Discussionmentioning

confidence: 97%

Spatial learning and psychomotor performance of C57BL/6 mice: age sensitivity and reliability of individual differences

Fiebre

Sumien

Forster

et al. 2006

AGE

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Two tests often used in aging research, the elevated path test and the Morris water maze test, were examined for their application to the study of brain aging in a large sample of C57BL/6JNia mice. Specifically, these studies assessed: (1) sensitivity to age and the degree of interrelatedness among different behavioral measures derived from these tests, (2) the effect of age on variation in the measurements, and (3) the reliability of individual differences in performance on the tests. Both tests detected age-related deficits in group performance that occurred independently of each other. However, analysis of data obtained on the Morris water maze test revealed three relatively independent components of cognitive performance. Performance in initial acquisition of spatial learning in the Morris maze was not highly correlated with performance during reversal learning (when mice were required to learn a new spatial location), whereas performance in both of those phases was independent of spatial performance assessed during a single probe trial administered at the end of acquisition training. Moreover, impaired performance during initial acquisition could be detected at an earlier age than impairments in reversal learning. There were modest but significant age-related increases in the variance of both elevated path test scores and in several measures of learning in the Morris maze test. Analysis of test scores of mice across repeated testing sessions confirmed reliability of the measurements obtained for cognitive and psychomotor function. Power calculations confirmed that there are sufficiently large age-related differences in elevated path test performance, relative to within age variability, to render this test useful for studies into the ability of an intervention to prevent or reverse age-related deficits in psychomotor performance. Power calculations indicated a need for larger sample sizes for detection of intervention effects on cognitive components of the Morris water maze test, at least when implemented at the ages tested in this study. Variability among old mice in both tests, including each of the various independent measures in the Morris maze, may be useful for elucidating the biological bases of different aspects of dysfunctional brain aging.

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Section: Discussionmentioning

confidence: 97%

Spatial learning and psychomotor performance of C57BL/6 mice: age sensitivity and reliability of individual differences

Fiebre

Sumien

Forster

et al. 2006

AGE

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“…In this case, repeated trials with relatively short inter-trial intervals permit rats to acquire a spatial search strategy in a novel environment under NMDA receptor blockade. However, like aged animals (Blalock et al, 2003; Foster et al, 1991; Foster and Kumar, 2007; Norris and Foster, 1999), impaired retention was observed over a 24 hr period after training (Ge et al , 2010; Holahan et al , 2005; Kesner and Dakis, 1995; McDonald et al , 2005). Together, the results indicate that aged animals and animals under NMDAR blockade can acquire novel spatial information; however, consolidation deficits are evident if this information needs to be maintained.…”

Section: Age-related Deficits In Consolidation Of Rapidly Acquired mentioning

confidence: 99%

Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity

Foster

2012

Progress in Neurobiology

145

157

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In humans, heterogeneity in the decline of hippocampal-dependent episodic memory is observed during aging. Rodents have been employed as models of age-related cognitive decline and the spatial water maze has been used to show variability in the emergence and extent of impaired hippocampal-dependent memory. Impairment in the consolidation of intermediate-term memory for rapidly acquired and flexible spatial information emerges early, in middle-age. As aging proceeds, deficits may broaden to include impaired incremental learning of a spatial reference memory. The extent and time course of impairment has been be linked to senescence of calcium (Ca2+) regulation and Ca2+-dependent synaptic plasticity mechanisms in region CA1. Specifically, aging is associated with altered function of N-methyl-D-aspartate receptors (NMDARs), voltage-dependent Ca2+ channels (VDCCs), and ryanodine receptors (RyRs) linked to intracellular Ca2+ stores (ICS). In young animals, NMDAR activation induces long-term potentiation of synaptic transmission (NMDAR-LTP), which is thought to mediate the rapid consolidation of intermediate-term memory. Oxidative stress, starting in middle-age, reduces NMDAR function. In addition, VDCCs and ICS can actively inhibit NMDAR-dependent LTP and oxidative stress enhances the role of VDCC and RyR-ICS in regulating synaptic plasticity. Blockade of L-type VDCCs promotes NMDAR-LTP and memory in older animals. Interestingly, pharmacological or genetic manipulations to reduce hippocampal NMDAR function readily impair memory consolidation or rapid learning, generally leaving incremental learning intact. Finally, evidence is mounting to indicate a role for VDCC-dependent synaptic plasticity in associative learning and the consolidation of remote memories. Thus, VDCC-dependent synaptic plasticity and extrahippocampal systems may contribute to incremental learning deficits observed with advanced aging.

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“…In model organisms, dysfunctional cognitive flexibility can arise following disinhibition of the prefrontal cortex (Gruber et al, 2010) and serves as the basis for selective deficits in reversal learning (Bartus et al, 1979;Holahan et al, 2005;Schoenbaum et al, 2006). When using the water maze to test reversal learning, subjects are sequentially trained to two platform locations in a basic version of a platform re-location task.…”

Section: Predicting Learning and Memory In Humansmentioning

confidence: 99%

Statistical and theoretical considerations for the platform re-location water maze

Saab

Roder

2011

Journal of Neuroscience Methods

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Impairment in long-term retention but not short-term performance on a water maze reversal task following hippocampal or mediodorsal striatal n-methyl-d-aspartate receptor blockade.

Cited by 19 publications

References 66 publications

Spatial learning and psychomotor performance of C57BL/6 mice: age sensitivity and reliability of individual differences

Spatial learning and psychomotor performance of C57BL/6 mice: age sensitivity and reliability of individual differences

Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity

Statistical and theoretical considerations for the platform re-location water maze

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