Statistical and theoretical considerations for the platform re-location water maze

Saab, Bechara J.; Saab, Adam; Roder, John

doi:10.1016/j.jneumeth.2011.03.008

Cited by 25 publications

(16 citation statements)

References 49 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The type of learning and memory tested by stable platform paradigms is arguably rare in humans because humans must continually build upon previous memories within a similar context. The Morris water maze task, in which the platform is relocated over time, might challenge learning and memory [14] . We therefore used a platform relocation water maze experiment to explore whether IMM-H004 can affect cognitive flexibility in rats that received an icv injection of OKA.…”

Section: Discussionmentioning

confidence: 99%

A new coumarin derivative, IMM-H004, attenuates okadaic acid-induced spatial memory impairment in rats

et al. 2016

View full text Add to dashboard Cite

Aim: A novel coumarin derivative 7-hydroxy-5-methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-coumarin (IMM-H004) has shown antiapoptotic, anti-inflammatory and neuroprotective activities. In this study we investigated the effects of IMM-H004 on spatial memory in rats treated with okadaic acid (OKA), which was used to imitate Alzheimer's disease (AD)-like symptoms. Methods: SD rats were administered IMM-H004 (8 mg·kg -1 ·d -1 , ig) or donepezil (positive control, 1 mg·kg -1 ·d -1 , ig) for 25 d. On d 8 and 9, OKA (200 ng) was microinjected into the right ventricle. Morris water maze test was used to evaluate the spatial memory impairments. Tau and β-amyloid (Aβ) pathology in the hippocampus was detected using Western blot and immunohistochemistry. TUNEL staining was used to detect cell apoptosis. Results: OKA-treated rats showed significant impairments of spatial memory in Morris water maze test, which were largely reversed by administration of IMM-H004 or donepezil. Furthermore, OKA-treated rats exhibited significantly increased phosphorylation of tau, deposits of Aβ protein and cell apoptosis in the hippocampus, which were also reversed by administration of IMM-H004 or donepezil. Conclusion: Administration of IMM-H004 or donepezil protects rats against OKA-induced spatial memory impairments via attenuating tau or Aβ pathology. Thus, IMM-H004 may be developed as a therapeutic agent for the treatment of AD.

show abstract

Section: Discussionmentioning

confidence: 99%

A new coumarin derivative, IMM-H004, attenuates okadaic acid-induced spatial memory impairment in rats

et al. 2016

View full text Add to dashboard Cite

show abstract

“…For this reason, water maze tasks that re-locate the platform over time might challenge learning and memory in important ways (Saab et al, 2011). We therefore used a platform re-location water maze experiment to explore whether Rg1 can affect cognitive flexibility in OKA i.c.v.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3β/tau signaling pathway and the Aβ formation prevention in rats

Song

Hu²,

Chu

et al. 2013

European Journal of Pharmacology

View full text Add to dashboard Cite

“…Cues were placed on each wall of the room, including a colourful (1m tall) plastic toy wagon jutting from the wall, a checker board (1 m x 1 m), a blue fitness ball (75 cm in diameter), and a cross of black stripes (each stripe 1.5 m x 30 cm). The task was performed as described (Saab et al, 2011) 7 with minor modifications. Mice were released randomly from one of five points far from the escape platform.…”

Section: Morris Water Mazementioning

confidence: 99%

Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission

Lipina

Prasad

Yokomaku

et al. 2015

Neuropsychopharmacol

View full text Add to dashboard Cite

Calsyntenin-2 has an evolutionarily conserved role in cognition. In a human genome-wide screen, the CLSTN2 locus was associated with verbal episodic memory, and expression of human calsyntenin-2 rescues the associative learning defect in orthologous Caenorhabditis elegans mutants. Other calsyntenins promote synapse development, calsyntenin-1 selectively of excitatory synapses and calsyntenin-3 of excitatory and inhibitory synapses. We found that targeted deletion of calsyntenin-2 in mice results in a selective reduction in functional inhibitory synapses. Reduced inhibitory transmission was associated with a selective reduction of parvalbumin interneurons in hippocampus and cortex. Clstn2(-/-) mice showed normal behavior in elevated plus maze, forced swim test, and novel object recognition assays. However, Clstn2(-/-) mice were hyperactive in the open field and showed deficits in spatial learning and memory in the Morris water maze and Barnes maze. These results confirm a function for calsyntenin-2 in cognitive performance and indicate an underlying mechanism that involves parvalbumin interneurons and aberrant inhibitory transmission.

show abstract

Statistical and theoretical considerations for the platform re-location water maze

Cited by 25 publications

References 49 publications

A new coumarin derivative, IMM-H004, attenuates okadaic acid-induced spatial memory impairment in rats

A new coumarin derivative, IMM-H004, attenuates okadaic acid-induced spatial memory impairment in rats

Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3β/tau signaling pathway and the Aβ formation prevention in rats

Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission

Contact Info

Product

Resources

About