Impaired strategic regulation of contents of conscious awareness in schizophrenia

Sonntag, Philippe; Gokalsing, Erick; Olivier, Carinne; Robert, Philippe; Burglen, Franck; Kauffmann-Muller, F.; Huron, Caroline; Salamé, Pierre; Danion, Jean-Marie

doi:10.1016/s1053-8100(03)00016-3

Cited by 35 publications

(27 citation statements)

References 23 publications

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“…Importantly, however, Yonelinas and Jacoby (1995) have developed an R/K method to compensate for this underestimation; consistent with most dual-process theories, this calculation method also assumes that recollection and familiarity are independent. Previous studies of patients with psychosis that have used the R/K procedure in a standard item recognition paradigm have found reduced R responses and similar or increased K responses for targets in patients relative to controls (Danion, Kazes, Huron, & Karchouni, 2003;Danion, Rizzo, & Bruant, 1999;Huron et al, 1995;Sonntag et al, 2003;Tendolkar, Ruhrmann, Brockhaus, Pukrop, & Klosterkotter, 2002;van Erp, 2008). These findings support the view that patients with psychosis have impaired recollection and possibly rely on preserved familiarity processes to compensate for poor recollection-based memory.…”

Section: Introductionsupporting

confidence: 62%

True and false memories in adolescents with psychosis: Evidence for impaired recollection and familiarity

Caza

Doré

Gingras

et al. 2011

Cognitive Neuropsychiatry

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Section: Introductionsupporting

confidence: 62%

True and false memories in adolescents with psychosis: Evidence for impaired recollection and familiarity

Caza

Doré

Gingras

et al. 2011

Cognitive Neuropsychiatry

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“…As noted above, efficient and capacitive working and long-term memory is needed for mental representation and perception of experiences in the context of past, present, and future. Disruption of systems such as working memory interacting with or driving atypical development in other brain systems that underpin autonoetic consciousness such as salience and long-term memory are likely part of the etiopathology of schizophrenia (Sonntag et al 2003;Wheeler et al 1997). …”

Section: Discussionmentioning

confidence: 99%

Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology

Sanders

Hobbs

Stephenson

et al. 2017

J Autism Dev Disord

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Stress and anxiety have a negative impact on working memory systems by competing for executive resources and attention. Broad memory deficits, anxiety, and elevated stress have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiological stress reactivity in relation to visuospatial working memory impairments in 20 children with 22q11.2DS and 32 typically developing (TD) children ages 7 to 16. Children with 22q11.2DS demonstrated poorer working memory, reduced post-stress respiratory sinus arrhythmia recovery, and overall increased levels of cortisol in comparison to TD children. Anxiety, but not physiological stress responsivity, mediated the relationship between 22q11.2DS diagnosis and visuospatial working memory impairment. Findings indicate that anxiety exacerbates impaired working memory in children with 22q11.2DS.

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“…Several studies using the Remember-Know (R-K) paradigm have provided evidence consistent with the view that patients with schizophrenia exhibit greater reduction in the use of conscious recollection than in the use of familiarity assessment as a basis for retrieval compared with controls Danion et al 2003;Danion et al 1999;Grillon et al 2005;Huron and Danion 2002;Huron et al 1995;Huron et al 2003;Neumann et al 2006;Ribeiro et al 2005;Sonntag et al 2003;Souchay et al 2006;Tendolkar et al 2002;Thoma et al 2006). In the R-K paradigm, when recognizing a memorandum as previously encountered, participants are asked to make a "remember" response when they retrieve contextual information that was part of the learning episode and a "know" response when they do not.…”

Section: Introductionmentioning

confidence: 86%

Remember and know judgments during recognition in chronic schizophrenia

Erp¹,

Lesh²,

Knowlton³

et al. 2008

Schizophrenia Research

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Deficits in learning and memory are among the most robust correlates of schizophrenia. It has been hypothesized that these deficits are in part due to reduced conscious recollection and increased reliance on familiarity assessment as a basis for retrieval. The Remember-Know (R-K) paradigm was administered to 35 patients with chronic schizophrenia and 35 healthy controls. In addition to making "remember" and "know" judgments, the participants were asked to make forced choice recognition judgments with regard to details about the learning episode. Analyses comparing response types showed a significant reduction in "remember" responses and a significant increase in "know" responses in schizophrenia patients relative to controls. Both patients and controls recalled more details of the learning episode for "remember" compared to "know" responses, although, in particular for "remember" responses, patients recalled fewer details compared with controls. Notably, patients recognized fewer inter-item but not intra-item stimulus features compared with controls. These findings suggest deficits in organizing and integrating relational information during the learning episode and/or using relational information for retrieval. A Dual-Process Signal Detection interpretation of these findings suggests that recollection in chronic schizophrenia is significantly reduced, while familiarity is not. Additionally, a unidimensional Signal Detection Theory interpretation suggests that chronic schizophrenia patients show a reduction in memory strength, and an altered criterion on the memory strength distribution for detecting new compared with old stimuli but not for detecting stimuli that are remembered versus familiar. Taken together, these findings are consistent with a deficit in recollection and increased reliance on familiarity in making recognition memory judgments in chronic schizophrenia.

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Impaired strategic regulation of contents of conscious awareness in schizophrenia

Cited by 35 publications

References 23 publications

True and false memories in adolescents with psychosis: Evidence for impaired recollection and familiarity

True and false memories in adolescents with psychosis: Evidence for impaired recollection and familiarity

Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology

Remember and know judgments during recognition in chronic schizophrenia

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